Paid Clinical Trials in Hershey, PA
As of June 2026, 293 paid clinical trials are recruiting in Hershey, Pennsylvania. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Hershey offers studies at sites including Penn State Milton S Hershey Medical Center for conditions such as Acute Myeloid Leukemia, Breast Cancer, Heart Failure, Neuroblastoma. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Hershey
Trials by drug in Hershey
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293 clinical trials
↓ Download CSVImpact of Electronic Cigarette Temperature and Solvent on Biomarkers
Penn State Emergency Medicine CarES: Care-partner Evaluation and Sourcing in the Emergency Department
Impact of Loss Aversion Messaging and Anticipated Regret for Inaction on Exercise Adherence in Older Adults
A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)
Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma
Health-E You Efficacy Trial for Male Adolescents
Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients
Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers?
Comparative Effectiveness of Two Different Approaches to Radiofrequency Ablation of Lumbar Medial Branch Nerves
Endo-SPONGE for Treatment of Anastomotic or Hartmann's Stump Leakages in Lower Pelvic Area
Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
Phase 2 Study to Assess the Safety and Efficacy of ANG003
Donidalorsen Treatment in Children With Hereditary Angioedema
AYA-PeerConnect: A Communication Coaching Intervention for Adolescent/Young Adult Cancer Survivors (AYACS)
CBG/CBD Oil for Chemotherapy-Induced Peripheral Neuropathy
Phase 3 Extension Study of ADX-324 in Participants With Hereditary Angioedema (HAE)
Ultrasound (US) Guided External Ventricular Catheter Placement
Little Cigar Oxidants
Developing an Artificial Intelligence (AI) Chatbot for Adolescents and Young Adults With Eating Disorders
Allogeneic HSCT With Low-Dose Post-Transplant Cyclophosphamide for GVHD Prevention
Predictors of Improvements in Irritability and Aggression in Children With ADHD Treated With CNS Stimulants
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
DVT Evaluation Using POCUS for Diagnosis and Treatment
Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students
Adapting Exposure for Adolescent AN
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)
Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma
Activating SilverSneakers Benefits for Seniors With Osteoarthritis
Optimizing Pain Treatment in Children On Mechanical Ventilation
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
Intervascular Post-Market Clinical Follow-Up (PMCF) Registry
Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer
A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitean-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer
Stories to Prevent (StoP) HPV Cancers
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
The WiSE®-UP Registry (The WiSE System Utilization & Performance Registry)
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
About research studies in Hershey
Hershey has approximately 293 recruiting research studies across a wide range of therapeutic areas. Pennsylvania hosts UPenn's Perelman School of Medicine and Children's Hospital of Philadelphia — pioneers in CAR-T cell therapy — alongside UPMC, Thomas Jefferson University, and Penn State Hershey.
Top Research Study Locations in Hershey
Researchers run research studies in Hershey, PA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Penn State Milton S Hershey Medical Center | Acute Myeloid Leukemia, Breast Cancer, Anatomic Stage II Breast Cancer AJCC v8 | 44 |
| Penn State Milton S. Hershey Medical Center | Blood Pressure, Gastroesophageal Junction Adenocarcinoma, NSCLC | 26 |
| Penn State Children's Hospital | Malignant Solid Neoplasm, Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia | 22 |
| Penn State Health Milton S. Hershey Medical Center | Alpha1-Antitrypsin Deficiency, Duchenne Muscular Dystrophy, Acute Ischemic Stroke | 17 |
| Penn State Health | Amyotrophic Lateral Sclerosis, Endometriosis, Heart Failure | 15 |
| Penn State College of Medicine | Anorexia Nervosa, Oxidative Stress, Tobacco Use | 14 |
| Penn State Hershey Medical Center | Acute Kidney Injury (AKI), Acute Myocardial Infarction (AMI), Atrial Fibrillation | 13 |
| Penn State Cancer Institute | Breast Cancer, Allogeneic Stem Cell Transplantation, Chemotherapy-Induced Peripheral Neuropathy | 9 |
| Penn State Milton S. Hershey Medical Center and Children's Hospital | Neuroblastoma, Ewing Sarcoma, Osteosarcoma | 8 |
| Pennsylvania State University | Articular Fractures, Body Image, Body Image Disturbance | 8 |
| Milton S. Hershey Medical Center | Amyotrophic Lateral Sclerosis, Anxiety, Caregiver Burden | 6 |
| Penn State Milton S Hershey Medical Ctr | Multiple Myeloma, Colitis, Ulcerative, Crohn Disease | 5 |
| Penn State Health Milton South Hershey Medical Center | Chronic Inflammatory Demyelinating Polyneuropathy, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Polyneuropathy, Inflammatory Demyelinating, Chronic | 5 |
| Penn State Hershey | Amyotrophic Lateral Sclerosis, Epilepsy, Neurologic Disorder | 4 |
| Hershey Medical Center Pennsylvania State University | Cystic Fibrosis, Cystic Fibrosis (CF), Exocrine Pancreatic Insufficiency (EPI) | 3 |
| Penn State University | Ards, Blood Pressure, Blood Pressure, High | 3 |
| The Pennsylvania State University | Antibiotics, Hypersensitivity Pneumonitis, Interstitial Lung Disease | 3 |
| ADARx Clinical Site | HAE, Hereditary Angioedema - Type 1, Hereditary Angioedema - Type 2 | 2 |
| Akero Clinical Study Site | MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, NASH - Nonalcoholic Steatohepatitis | 2 |
| Penn State Health Dept of Psychiatry | ADHD, ADHD - Attention Deficit Disorder With Hyperactivity, Aggression Childhood | 2 |
| Penn State Health Medical Group - Psychiatry and Behavioral Health | Anxiety, Attention-Deficit/Hyperactivity Disorder, Chronic Stress | 2 |
| Penn State Health Milton S. Hershey Medical Center (Hershey) | Hematologic Tests | 2 |
| Penn State Health, Milton S. Hershey Medical Center | Deep Venous Thromboses, Hepatitis | 2 |
| Penn State Hershey Children's Hospital | Anesthesia, Children, Deep Venous Thrombosis | 2 |
| Penn State Milton S. Hershey Medical Center / Penn State College of Medicine | Child Abuse, Child Maltreatment, Child Neglect | 2 |
Active & Upcoming Studies in Hershey (2026)
Recruiting trials in Hershey grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (100 active studies)
- Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma · Phase 2 · Milton S. Hershey Medical Center
- Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas · Phase 1, Phase 2 · Milton S. Hershey Medical Center
Cardiovascular (17 active studies)
- The WiSE®-UP Registry (The WiSE System Utilization & Performance Registry) · EBR Systems, Inc.
- Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus in The Emergency Department (LA CLOTTED) · Ottawa Heart Institute Research Corporation
Neurology & pain (10 active studies)
- Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke · Phase 3 · Pharmazz, Inc.
- Feasibility of a Mindfulness Intervention for Endometriosis Surgery · Milton S. Hershey Medical Center
Pediatric (8 active studies)
- Optimizing Pain Treatment in Children On Mechanical Ventilation · Phase 3 · Weill Medical College of Cornell University
- Optimizing Tracheal Intubation Outcomes and Neonatal Safety · Children's Hospital of Philadelphia
Mental health & behavior (7 active studies)
- Impact of Electronic Cigarette Temperature and Solvent on Biomarkers · Milton S. Hershey Medical Center
- AYA-PeerConnect: A Communication Coaching Intervention for Adolescent/Young Adult Cancer Survivors (AYACS) · Milton S. Hershey Medical Center
Diabetes & metabolic (5 active studies)
- Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension · EARLY_Phase 1 · Milton S. Hershey Medical Center
- A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH · Phase 3 · Akero Therapeutics, Inc
Vaccines (1 active study)
HIV / STI (1 active study)
- Health-E You Efficacy Trial for Male Adolescents · Johns Hopkins University
Eye & vision (1 active study)
- Evaluation of a Monofocal Intraocular Lens · Phase 4 · Carl Zeiss Meditec AG
Common conditions studied in Hershey
- Acute Myeloid Leukemia (7 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
- Breast Cancer (7 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Heart Failure (7 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Neuroblastoma (6 active studies). Recruiting Neuroblastoma studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Hereditary Angioedema (HAE) (5 active studies). Recruiting Hereditary Angioedema (HAE) studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Prostate Cancer (5 active studies). Prostate cancer studies test next-generation hormone therapies, PARP inhibitors, and radioligand treatments for both localized and advanced disease.
Leading research sponsors in Hershey
- Milton S. Hershey Medical Center
- National Cancer Institute (NCI)
- NRG Oncology
- Children's Oncology Group
- AstraZeneca
Local regulations and guidelines
Clinical trials in Pennsylvania are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Pennsylvania research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Hershey. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Hershey
Hipa.ai aggregates every recruiting study in Hershey from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Hershey?
There are approximately 293 recruiting clinical trials in Hershey, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Hershey pay participants?
Most recruiting trials in Hershey compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Hershey?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Hershey?
The most common conditions under active study in Hershey include Acute Myeloid Leukemia (7), Breast Cancer (7), Heart Failure (7), Neuroblastoma (6), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Hershey?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Hershey on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Hershey?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Hershey?
Recruiting research sites in Hershey include Penn State Milton S Hershey Medical Center, Penn State Milton S. Hershey Medical Center, Penn State Children's Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Hershey right now?
The largest active categories in Hershey are Cancer & tumors (100), Cardiovascular (17), Neurology & pain (10). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.