A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

Part of paid clinical trials in Chandler, Arizona.

Sponsor
Incyte Corporation
Study ID
NCT07284849
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

  • CRC (Colorectal Cancer)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • INCA33890 — DRUG
    INCA33890 will be administered at protocol defined dose.
  • Placebo — DRUG
    Placebo will be administered at protocol defined dose.
  • Bevacizumab — DRUG
    Bevacizumab will be administered at protocol defined dose.
  • FOLFOX — DRUG
    FOLFOX will be administered at protocol defined dose.

Study Details

The purpose of this study is to evaluate the efficacy and safety of standard-of-care chemotherapy and bevacizumab with or without INCA33890 in the first-line treatment of metastatic microsatellite stable colorectal cancer.

Key Dates

Start date
Mar 5, 2026
Status verified
May 2026
Primary completion
Dec 29, 2028
Completion
Sep 28, 2029

Study Design

Enrollment
700 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: INCA33890
    INCA33890 will be administered in combination with bevacizumab and FOLFOX at the protocol-defined dose.
  • Placebo Comparator: Placebo
    Placebo will be administered in combination with bevacizumab and FOLFOX at the protocol-defined dose.

Primary Outcome Measure

Progression-Free Survival (PFS) [ Time Frame: Up to 3 years ]

Central Contacts

Locations (80)

FacilityCityStateZIPSite coordinators
Ironwood Cancer & Research CentersChandlerArizona85224-5665-
Roche Tissue Diagnostics, Companion DiagnosticsTucsonArizona85755-
The University of Arizona Cancer CenterTucsonArizona85719-
Los Angeles Cancer NetworkAnaheimCalifornia92801-
Memorial Care Orange Coast Medical CenterFountain ValleyCalifornia92708-
Providence Medical FoundationFullertonCalifornia92835-
Cancer & Blood Research CenterLos AlamitosCalifornia90720-
University of California Los Angeles HealthLos AngelesCalifornia90095-
Sarah Cannon Research Institute Scri Oncology PartnersAuroraColorado80012-
Hartford HospitalHartfordConnecticut06102-
George Washington UniversityWashington D.C.District of Columbia20037-
Florida Oncology & HematologyFort MyersFlorida33912-
University of Florida HealthGainesvilleFlorida32610-
Sylvester Comprehensive Cancer CenterMiamiFlorida33136-
Advent HealthOrlandoFlorida32804-
Orlando Health Cancer Institute Downtown OrlandoOrlandoFlorida32806-
Ascension Sacred Heart PensacolaPensacolaFlorida32504-
H. Lee Moffitt Cancer Center and Research Institute HospitalTampaFlorida33612-9497-
Tampa General Hospital-Cancer InstituteTampaFlorida33606-
Piedmont Cancer InstituteLocust GroveGeorgia30248-
University of Hawaii Cancer CenterHonoluluHawaii96813-2402-
St Lukes Mountain States Tumor Institute Msti BoiseBoiseIdaho83712-
University of Illinois Cancer CenterChicagoIllinois60612-
Endeavor HealthEvanstonIllinois60201-
Springfield ClinicSpringfieldIllinois62702-
Community Health Network, Inc.IndianapolisIndiana46250-
Hematology Oncology of IndianaIndianapolisIndiana46260-
Iu Simon Cancer CenterIndianapolisIndiana46202-
University of Iowa Hospital and ClinicsIowa CityIowa52242-
Ochsner Clinic Foundation Ocf Ochsner Cancer Institute OciNew OrleansLouisiana70121-
Saint Agnes HospitalBaltimoreMaryland21229-5201-
Cancer Center For Blood Disorders A Division of American Oncology Partners P.ABethesdaMaryland20817-
Sarah Cannon Research Institute Scri Oncology PartnersBrandywineMaryland20613-
Massachusetts General HospitalBostonMassachusetts02114-
St. Joseph Mercy HospitalAnn ArborMichigan48197-
University of MichiganAnn ArborMichigan48109-
Henry Ford HospitalDetroitMichigan48202-
Missouri Cancer AssociatesColumbiaMissouri65201-
Midamerica Cancer CareKansas CityMissouri64121-
Saint Luke'S Hospital of Kansas CityKansas CityMissouri64111-
Oncology Hematology AssociatesSpringfieldMissouri65807-
Washington University School of MedicineSt LouisMissouri63110-
Morristown Medical CenterMorristownNew Jersey07960-
Presbyterian Rust Medical CenterRio RanchoNew Mexico87124-
Monter Cancer CenterNew Hyde ParkNew York11042-
Icahn School of Medicine At Mount SinaiNew YorkNew York10019-
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065-
University of RochesterRochesterNew York14623-2327-
Ny Cancer and Blood SpecialistsShirleyNew York11967-
Montefiore Einstein For Cancer CareThe BronxNew York10461-
Messino Cancer CenterAshevilleNorth Carolina28806-
The University of North Carolina At Chapel HillChapel HillNorth Carolina27514-
Oncology Specialists of CharlotteCharlotteNorth Carolina28207-
University of Cincinnati Cancer InstituteCincinnatiOhio45219-
Ohio HealthColumbusOhio43214-
Ohio State University-Arthur G James Comprehensive Cancer CenterColumbusOhio43210-
St. Luke'S Health NetworkBethlehemPennsylvania18015-
Alliance Cancer SpecialistsDoylestownPennsylvania18901-
Penn State Milton S. Hershey Medical CenterHersheyPennsylvania17033-
Hillman Cancer CenterMonroevillePennsylvania15146-
Sidney Kimmel Comprehensive Cancer CenterPhiladelphiaPennsylvania19107-
University of PennsylvaniaPhiladelphiaPennsylvania19104-
Allegheny General Hospital Cancer InstitutePittsburghPennsylvania15212-
Cancer Care Associates of YorkYorkPennsylvania17403-
Avera Cancer InstituteSioux FallsSouth Dakota57105-
Provision Center For Biomedical ResearchKnoxvilleTennessee37909-
Sarah Cannon Research Institute Scri Oncology PartnersNashvilleTennessee37203-
Tennessee Oncology, PllcNashvilleTennessee37203-
Ascension Seton Spclty Care CtrAustinTexas78712-
Texas OncologyAustinTexas78745-
University of Texas Southwestern Medical CenterDallasTexas75235-
Md Anderson Cancer CenterHoustonTexas77030-
Baylor Scott & White HealthTempleTexas76508-
University of Virginia Medical CenterCharlottesvilleVirginia22908-
Inova Schar Cancer InstituteFairfaxVirginia22031-4867-
Shenandoah OncologyWinchesterVirginia22601-
Fred Hutchinson Cancer CenterSeattleWashington98109-
Cancer Care NorthwestSpokaneWashington99202-
Vandalia Health Charleston Area Medical CenterCharlestonWest Virginia25304-
West Virginia University Cancer InstituteMorgantownWest Virginia26506-

Find similar trials in Chandler, AZ

By research site
Ironwood Cancer & Research Centers· Chandler, AZRoche Tissue Diagnostics, Companion Diagnostics· Tucson, AZThe University of Arizona Cancer Center· Tucson, AZLos Angeles Cancer Network· Anaheim, CAMemorial Care Orange Coast Medical Center· Fountain Valley, CAProvidence Medical Foundation· Fullerton, CA

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