ALS — Trials, FDA Actions & Pivotal Research

20 active ALS trials currently recruiting in the US, sourced from ClinicalTrials.gov.

Synced daily from openFDA and ClinicalTrials.gov. Last sync: June 12, 2026.

Recruiting trials by city

Cities where ALS trials in our archive had recruiting sites. Each link lists every currently recruiting paid clinical trial at that location.

Birmingham, AL Boston, MA Fort Lauderdale, FL Jacksonville, FL Sacramento, CA Irvine, CA La Jolla, CA Loma Linda, CA Miami, FL San Francisco, CA Chicago, IL Gainesville, FL

Active ALS trials

Currently recruiting US trials matching ALS, sourced live from ClinicalTrials.gov. We’ll add per-event articles here as those trials post results or hit primary completion.

Study of [11C]CPPC as a Clinical PET Radioligand Biomarker of Microglial Activation in ALS

for ALS

Sponsor: Johns Hopkins University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05602142·Phase 1, Phase 2·Not Yet Recruiting

Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients

for Post-stroke

Sponsor: Marta Mondellini

Sex: All·Age: 18+

Code: NCT07616050·Not Yet Recruiting

iBCI Optimization for Veterans With Paralysis

for Spinal Cord Injury

1 location in Providence

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 80

Code: NCT05470478·Not Yet Recruiting

Therapeutic Approach of Repeated Transient Blood-brain Barrier Opening in Amyotrophic Lateral Sclerosis.

for Amyotrophic Lateral Sclerosis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18 - 80

Code: NCT07571486·Phase 1, Phase 2·Not Yet Recruiting

A Substudy of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis

for Amyotrophic Lateral Sclerosis

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07571174·Phase 1·Not Yet Recruiting

A Master Protocol (OLMP): A Study of LY4256984 in Participants With Amyotrophic Lateral Sclerosis (ALS)

for Amyotrophic Lateral Sclerosis

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07571200·Phase 1·Not Yet Recruiting

Alter-Ego as an Assistive Robotic Device.

for Amyotrophic Lateral Sclerosis

Sponsor: University of Pisa

Sex: All·Age: 18 - 80

Code: NCT07572838·Not Yet Recruiting

TP04HN106 in the Treatment of Patients With Amyotrophic Lateral Sclerosis

for Amyotrophic Lateral Sclerosis

Sponsor: Talengen Institute of Life Sciences, Shenzhen, P.R. China.

Sex: All·Age: 18+

Code: NCT06726577·Phase 1, Phase 2·Recruiting

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Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis

for Amyotrophic Lateral Sclerosis

1 location in Iowa City

Sponsor: University of Iowa

Sex: All·Age: 18 - 80

Code: NCT07224269·EARLY_Phase 1·Not Yet Recruiting

Digital Speech Markers for Monitoring ALS in Spanish Speakers

for Amyotrophic Lateral Sclerosis

1 location in Fort Lauderdale

Sponsor: Nova Southeastern University

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT07341334·Not Yet Recruiting

Research of Traditional Chinese Medicine Oral Preparation of C. Cicadae in the Treatment of ALS Patients With Elevated Plasma Sphingolipids

for Amyotrophic Lateral Sclerosis

Sponsor: The Third Xiangya Hospital of Central South University

Sex: All·Age: 18 - 80

Code: NCT07467746·Phase 2·Not Yet Recruiting

INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study

for Neurological Disorder

5 locations incl. Jacksonville

Sponsor: Synchron, Inc.

Sex: All·Age: 22+

Code: NCT07543367·Recruiting

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A Study to Evaluate the Safety, Efficacy, and Pharmacodynamics of PLL001 in ALS Patients

for Amyotrophic Lateral Sclerosis

Sponsor: PLL TX AUSTRALIA PTY LTD

Sex: All·Age: 18 - 75

Code: NCT06513546·Phase 1, Phase 2·Not Yet Recruiting

Metagenomic Characterization of the Intestinal Microbiota in ALS Patients and Association With Clinical Phenotypes

for Amyotrophic Lateral Sclerosis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT06771414·Not Yet Recruiting

Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

for Amyotrophic Lateral Sclerosis

3 locations incl. Sacramento

Sponsor: Paradromics

Sex: All·Age: 22 - 75

Code: NCT07357428·Recruiting

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Personalized Antisense Oligonucleotide Therapy for A Single Patient With CHCHD10 ALS (nL18576)

for Amyotrophic Lateral Sclerosis

1 location in Rochester

Sponsor: n-Lorem Foundation

Sex: All·Age: 18+

Code: NCT07423494·Phase 1, Phase 2·Not Yet Recruiting

Diagnostic Accuracy of SleepImage Technology for Detecting Respiratory Failure in Patients With Amyotrophic Lateral Sclerosis

for Amyotrophic Lateral Sclerosis

Sponsor: Royal Brompton & Harefield NHS Foundation Trust

Sex: All·Age: 18+

Code: NCT07502677·Recruiting

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Functional Outcomes and Control Using Synchron BCI - Canada

for Neurologic Disorder

Sponsor: Synchron, Inc.

Sex: All·Age: 18+

Code: NCT07446114·Recruiting

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Healey ALS MyMatch Common Screening Protocol

for ALS

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07400393·Not Yet Recruiting

Chinese-Specific Speech Imagery Coding Using High-Density ECoG

for Aphasia

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Sex: All·Age: 20 - 80

Code: NCT07460037·Recruiting

Apply to this trial