Esophageal Cancer — Trials, FDA Actions & Pivotal Research

20 active Esophageal Cancer trials currently recruiting in the US, sourced from ClinicalTrials.gov.

Synced daily from openFDA and ClinicalTrials.gov. Last sync: June 12, 2026.

Recruiting trials by city

Cities where Esophageal Cancer trials in our archive had recruiting sites. Each link lists every currently recruiting paid clinical trial at that location.

Duarte, CA Boston, MA Los Angeles, CA Aurora, CO Birmingham, AL Denver, CO Beverly Hills, CA San Diego, CA Ann Arbor, MI Cleveland, OH

Active Esophageal Cancer trials

Currently recruiting US trials matching Esophageal Cancer, sourced live from ClinicalTrials.gov. We’ll add per-event articles here as those trials post results or hit primary completion.

Adaptive Neoadjuvant Therapy for Esophageal Cancer

for Esophageal Carcinoma

Sponsor: Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center

Sex: All·Age: 18 - 75

Code: NCT06990178·Enrolling By Invitation

Outside the Cage (OTC) Robotic Esophagectomy

for Esophageal Cancer

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All·Age: 18+

Code: NCT06735638·Phase 1·Not Yet Recruiting

Evaluation of the Administration of Artificial Nutrition by Feeding Jejunostomy During Neoadjuvant Treatment on Postoperative Morbidity in the Context of Esophageal or Stomach Cancer

for Esophageal Cancer

Sponsor: University Hospital, Bordeaux

Sex: All·Age: 18+

Code: NCT07584577·Recruiting

Apply to this trial

Pharmacokinetics Study of Larotinib in Subjects With Impaired Hepatic Function

for Esophageal Cancer

Sponsor: Sunshine Lake Pharma Co., Ltd.

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT05048368·Phase 1·Not Yet Recruiting

The Value of Near-Infrared Fluorescence Imaging in the Protection of the Recurrent Laryngeal Nerve During Minimally Invasive Esophagectomy

for Esophageal Cancer

Sponsor: Fujian Medical University Union Hospital

Sex: All·Age: 18 - 75

Code: NCT07406815·Phase 3·Not Yet Recruiting

A Phase 1 Study of IM-1617 in Participants With Advanced Cancer

for Colorectal Cancer

1 location in Irving

Sponsor: Immunome, Inc.

Sex: All·Age: 18+

Code: NCT07578571·Phase 1·Recruiting

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Exercise Training After Upper Gastrointestinal Cancer Surgery

for Esophageal Cancer

Sponsor: Kansai Medical University

Sex: All·Age: 18+

Code: NCT07561840·Recruiting

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The Impact of Surgical Treatment on Survival in Localized Small Cell Esophageal Cancer

for Esophageal Carcinoma

Sponsor: yi shen

Sex: All·Age: 18+

Code: NCT07596654·Recruiting

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Circulating Tumor DNA MRD-Guided Adjuvant Therapy for Curatively Resected Locally Advanced Esophageal Squamous Cell Carcinoma

for Esophageal Cancer

Sponsor: Asan Medical Center

Sex: All·Age: 19+

Code: NCT06914011·Phase 3·Not Yet Recruiting

A Prospective Study of Tumor-specific Tpex in Negative Lymph Nodes for Predicting Pathological Complete Response to Neoadjuvant PD 1 Therapy in Esophageal Cancer

for Esophageal Cancer

Sponsor: Fudan University

Sex: All·Age: 18+

Code: NCT07573397·Not Yet Recruiting

PAravertebral CaTheter Versus Epidural Analgesia in Totally Minimally Invasive Esophagectomies

for Esophageal Cancer

Sponsor: University Hospital, Lille

Sex: All·Age: 18+

Code: NCT07434739·Not Yet Recruiting

Timing of Minimally Invasive Local Treatment After First-Line Systemic Therapy in Oligometastatic Esophageal or Gastric Adenocarcinoma

for Esophageal Cancer

Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Sex: All·Age: 18+

Code: NCT07000253·Phase 2, Phase 3·Recruiting

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Tpex Subsets in Negative Tumor Draining Lymph Nodes for Predicting the Efficacy of PD 1 Inhibitors in Advanced or Recurrent Esophageal Squamous Cell Carcinoma

for Esophageal Cancer

Sponsor: Fudan University

Sex: All·Age: 18+

Code: NCT07533357·Not Yet Recruiting

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

for Non-Small-Cell Lung

4 locations incl. Denver

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07519655·Phase 1·Recruiting

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The Application of Symptoms Management Program Based on the Patient Reported Outcome After Esophagectomy

for Esophageal Cancer

Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Sex: All·Age: 18+

Code: NCT07187154·Not Yet Recruiting

Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal Cancers

for Gastric Cancer

Sponsor: Blokhin's Russian Cancer Research Center

Sex: All·Age: 18+

Code: NCT07464470·Recruiting

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Stereotactic Body Radiation Therapy (SBRT) and Immunotherapy for Oligometastatic Esophageal Cancer

for Esophageal Cancer

Sponsor: AHS Cancer Control Alberta

Sex: All·Age: 18+

Code: NCT07330583·Phase 2·Not Yet Recruiting

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

for Ampulla of Vater Carcinoma

309 locations incl. Moose Lake

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07283939·Recruiting

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Clinical Trial Evaluating TQB6411 Injection in Subjects With Esophageal Cancer

for Esophageal Cancer

Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07367516·Phase 1, Phase 2·Recruiting

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

77 locations incl. Phoenix

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting

Apply to this trial