A Prospective Study of Tumor-specific Tpex in Negative Lymph Nodes for Predicting Pathological Complete Response to Neoadjuvant PD 1 Therapy in Esophageal Cancer

Sponsor
Fudan University
Study ID
NCT07573397
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The goal of this observational study is to to determine whether patients with a high proportion of precursor exhausted T cells (Tpex) in negative tumor draining lymph nodes have higher pCR. The main question it aims to answer is: Whether precursor exhausted T cells (Tpex) in negative tumor-draining lymph nodes have better predictive efficacy for treatment response than PD-L1 CPS.

Key Dates

Start date
May 6, 2026
Status verified
May 2026
Primary completion
May 1, 2028
Completion
Aug 20, 2028

Study Design

Enrollment
88 participants (estimated)

Arms

  • Arm: PD-1 treatment group

Primary Outcome Measure

pCR rate [ Time Frame: From enrollment to the surgery ]

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