Tpex Subsets in Negative Tumor Draining Lymph Nodes for Predicting the Efficacy of PD 1 Inhibitors in Advanced or Recurrent Esophageal Squamous Cell Carcinoma

Sponsor
Fudan University
Study ID
NCT07533357
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The goal of this observational study is to to determine whether patients with a high proportion of precursor exhausted T cells (Tpex) in negative tumor draining lymph nodes have longer overall survival. The main question it aims to answer is: Whether precursor exhausted T cells (Tpex) in negative tumor-draining lymph nodes have better predictive efficacy for treatment response than PD-L1 CPS.

Key Dates

Start date
Apr 20, 2026
Status verified
Apr 2026
Primary completion
Apr 6, 2029
Completion
Apr 6, 2029

Study Design

Enrollment
158 participants (estimated)

Arms

  • Arm: PD-1 treatment group
    PD-1 treatment group

Primary Outcome Measure

overall survival [ Time Frame: 2 years ]

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