An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia.

Part of paid clinical trials in Los Angeles, California.

Sponsor
NGM Biopharmaceuticals, Inc
Study ID
NCT07033026
Phase
PHASE2
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • NGM120 Q4W — DRUG
    NGM120 given subcutaneously every 4 weeks
  • NGM120 Q8W — DRUG
    NGM120 given subcutaneously every 8 weeks
  • Placebo given — DRUG
    Placebo given subcutaneously every 4 weeks

Study Details

A multi-center evaluation of NGM120 in a randomized, double-blind, placebo-controlled study in participants with colorectal cancer who have cancer cachexia.

Key Dates

Start date
Jun 25, 2025
Status verified
Mar 2026
Primary completion
Apr 30, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
136 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: NGM120 Treatment Group A
    NGM120 low dose given subcutaneously every 4 weeks
  • Placebo Comparator: NGM120 Treatment Group B
    Placebo low dose given subcutaneously every 4 weeks
  • Experimental: NGM120 Treatment Group C
    NGM120 high dose given subcutaneously every 4 weeks
  • Experimental: NGM120 Treatment Group D
    NGM120 high dose given subcutaneously every 8 weeks
  • Placebo Comparator: NGM120 Treatment Group E
    Placebo high dose given subcutaneously every 4 weeks

Primary Outcome Measure

Change from baseline in body weight at Week 12 [ Time Frame: 12 Weeks ]

Central Contacts

Locations (13)

FacilityCityStateZIPSite coordinators
NGM Clinical Study SiteLos AngelesCalifornia90033
NGM Site 115
[email protected]
NGM Clinical Study SiteLos AngelesCalifornia90095
NGM Site 105
[email protected]
NGM Clinical Study SiteSanta RosaCalifornia95403
NGM Site 103
[email protected]
NGM Clinical Study SiteMargateFlorida33063
NGM Site 106
[email protected]
NGM Clinical Study SiteBaltimoreMaryland21201
NGM Site 104
[email protected]
NGM Clinical Study SiteNew YorkNew York10065
NGM Site 113
[email protected]
NGM Clinical Study SiteToledoOhio43608
NGM Site 109
[email protected]
NGM Clinical Study SiteYoungstownOhio44504
NGM Site 111
[email protected]
NGM Clinical Study SiteDallasTexas75390
NGM Site 102
[email protected]
NGM Clinical Study SiteKingwoodTexas77339-
NGM Clinical Study SiteLaredoTexas78041
NGM Site 101
[email protected]
NGM Clinical Study SiteRichmondVirginia23114
NGM Site 114
[email protected]
NGM Clinical Study SiteAppletonWisconsin54915
NGM Site 112
[email protected]

Find similar trials in Los Angeles, CA

By condition
Colorectal cancer
By specialty
OncologyGI oncology
By research site
NGM Clinical Study Site· Los Angeles, CANGM Clinical Study Site· Santa Rosa, CANGM Clinical Study Site· Margate, FLNGM Clinical Study Site· Baltimore, MDNGM Clinical Study Site· New York, NYNGM Clinical Study Site· Toledo, OH

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