A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer

Part of paid clinical trials in Chandler, Arizona.

Sponsor
Janssen Research & Development, LLC
Study ID
NCT07225946
Phase
PHASE3
Status
Recruiting
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Conditions

  • Prostatic Neoplasms, Castration-Resistant

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Pasritamig — DRUG
    Pasritamig will be administered.
  • Docetaxel — DRUG
    Docetaxel will be administered.
  • Prednisone — DRUG
    Prednisone will be administered.

Study Details

The purpose of this study is to find out whether treatment with pasritamig and docetaxel prolongs radiographic progression free survival (rPFS) (the length of time from start of treatment until disease worsens as determined by scans) when compared to treatment with docetaxel in participants with metastatic castrate-resistant prostate cancer (mCRPC; a cancer of prostate, a male reproductive gland found below the bladder, that grows despite low levels of male hormones).

Key Dates

Start date
Dec 19, 2025
Status verified
Jun 2026
Primary completion
Nov 19, 2027
Completion
Jul 20, 2029

Study Design

Enrollment
800 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Pasritamig+Docetaxel
    Participants will receive pasritamig along with docetaxel until the end of trial (EOT) visit or until confirmed radiographic progression by blinded independent central review (BICR), or any other protocol defined criteria are met.
  • Active Comparator: Docetaxel
    Participants will receive docetaxel along with prednisone as background medication.

Primary Outcome Measure

Radiographic Progression-Free Survival (rPFS) Assessed by BICR [ Time Frame: Up to approximately 1 years 10 months ]

Central Contacts

Locations (49)

FacilityCityStateZIPSite coordinators
Arizona Clinical TrialsChandlerArizona85225-
Arkansas UrologyLittle RockArkansas72211-
MemorialCare Orange Coast Medical CenterFountain ValleyCalifornia92708-
University Of California San DiegoLa JollaCalifornia92037-
USC Norris Comprehensive Cancer CenterLos AngelesCalifornia90033-
Valkyrie Clinical TrialsLos AngelesCalifornia90067-
Kaiser Permanente Southern CaliforniaRiversideCalifornia92505-
Sharp Center for ResearchSan DiegoCalifornia92123-
Providence Saint John s Health CenterSanta MonicaCalifornia90404-
Rocky Mountain Cancer CentersAuroraColorado80012-
Grand Valley OncologyGrand JunctionColorado81505-
Colorado Clinical ResearchLakewoodColorado80228-
Florida Cancer SpecialistsSarasotaFlorida34232-
Winship Cancer Institute Emory UniversityAtlantaGeorgia30322-
Duly Health and CareLisleIllinois60532-
Cancer Center of Kansas Heritage Plaza Medical BuildingWichitaKansas67214-
St Elizabeth HealthcareEdgewoodKentucky41017-
Norton Cancer InstituteLouisvilleKentucky40207-
East Jefferson General HospitalMetairieLouisiana70006-
Johns Hopkins HospitalBaltimoreMaryland21287-
Johns Hopkins Medical InstitutionsBaltimoreMaryland21287-
University of MarylandBaltimoreMaryland21201-
Chesapeake Urology Research AssociatesTowsonMaryland21204-
Profound Research LLC at Cancer and Leukemia CenterSterling HeightsMichigan48314-
HealthPartners Frauenshuh Cancer Center CRC WestSaint Louis ParkMinnesota55426-
HealthPartners Cancer Center at Regions Hospital CRC EastSaint PaulMinnesota55101-
Washington UniversitySt LouisMissouri63110-
NHO Revive Research Institute, LLCLincolnNebraska68506-
Astera Cancer CareEast BrunswickNew Jersey08816-
Rutgers Cancer Institute of New JerseyNew BrunswickNew Jersey08901-
Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long IslandMineolaNew York11501-
NYU Langone Health Laura and Isaac Perlmutter Cancer CenterNew YorkNew York10016-
Montefiore Medical CenterThe BronxNew York10461-
University of CincinnatiCincinnatiOhio45219-
Oregon Urology InstituteSpringfieldOregon97477-
Lehigh Valley HospitalAllentownPennsylvania18103-
MidLantic UrologyBala-CynwydPennsylvania19004-
Penn State Milton S. Hershey Medical CenterHersheyPennsylvania17033-
University Of Pittsburgh Medical Center UPMC Hillman Cancer CenterPittsburghPennsylvania15232-
Carolina Urologic Research CenterMyrtle BeachSouth Carolina29572-
Avera Medical GroupSioux FallsSouth Dakota57105-
Tennessee Cancer SpecialistsKnoxvilleTennessee37909-
Texas OncologyAustinTexas78731-
UT Southwestern Medical CenterDallasTexas75390-
Houston Metro UrologyHoustonTexas77027-
Texas Oncology 1Sugar LandTexas77479-
Virginia Cancer SpecialistsFairfaxVirginia22031-
Fred Hutch Cancer Center Sloan Clinic 2SeattleWashington98109-
Fred Hutchinson Cancer Research CenterSeattleWashington98109-

Find similar trials in Chandler, AZ

By research site
Arizona Clinical Trials· Chandler, AZArkansas Urology· Little Rock, ARMemorialCare Orange Coast Medical Center· Fountain Valley, CAUniversity Of California San Diego· La Jolla, CAUSC Norris Comprehensive Cancer Center· Los Angeles, CAValkyrie Clinical Trials· Los Angeles, CA

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