Paid Clinical Trials in Lancaster, PA
As of June 2026, 80 paid clinical trials are recruiting in Lancaster, Pennsylvania. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Lancaster offers studies at sites including Lancaster General Hospital for conditions such as Heart Failure, Amblyopia, Breast Cancer, Neoplasm Metastasis. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Lancaster
Trials by drug in Lancaster
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80 clinical trials
↓ Download CSVAn Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)
MyStroke for Stroke Survivors and Caregivers
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Colorectal Cancer
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
Foundational Programs to Combat Clinician Stress
A Study to Evaluate TAR-210 Versus Intravesical Chemotherapy Treatment in Participants With High Risk Non-Muscle-Invasive Bladder Cancer
A Study of Pasritamig Versus Placebo in Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention
ELEVATE-HFpEF Clinical Study
TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Practical Geriatric Assessment (PGA) Implementation Strategies and Correlative Evaluations (PACE-70)
E-Mindfulness Approaches for Living After Breast Cancer
Efficacy and Safety of TYRA-300 in Participants With FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer
Vancomycin Reduction Practices (VRP) in the NICU
Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)
Dilated Cardiomyopathy Detection Using AI and Screening With Mobile Technology (DCM-DETECT)
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study
Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension
Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer
A Trial to Evaluate Intravesical Nadofaragene Firadenovec Alone or in Combination With Chemotherapy or Immunotherapy in Participants With High-grade BCG Unresponsive Non-muscle Invasive Bladder Cancer
LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC
A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)
Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial
Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age
Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial
A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)
A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer
About research studies in Lancaster
Lancaster has approximately 80 recruiting research studies across a wide range of therapeutic areas. Pennsylvania hosts UPenn's Perelman School of Medicine and Children's Hospital of Philadelphia — pioneers in CAR-T cell therapy — alongside UPMC, Thomas Jefferson University, and Penn State Hershey.
Top Research Study Locations in Lancaster
Researchers run research studies in Lancaster, PA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Lancaster General Hospital | Heart Failure, Abdominal Wound Dehiscence, Advanced Cancer | 15 |
| Lancaster General Ann B Barshinger Cancer Institute | Breast Cancer, Advanced Esophageal Adenocarcinoma, Advanced Gastric Adenocarcinoma | 10 |
| Keystone Urology Specialists | Non-Muscle Invasive Bladder Neoplasms, FGFR Gene Alterations, FGFR Gene Amplification | 9 |
| Lancaster General Hospital - Ann B Barshinger Cancer Institute | Neoplasm Metastasis, Breast Neoplasms, Carcinoma, Transitional Cell | 7 |
| Lancaster General Health | Cancer, Cardiovascular Disease and Lipoprotein(a), Hypertension | 4 |
| Penn Medicine Lancaster General Health | Burnout, Professional, Cardiovascular Diseases, Functional Mitral Regurgitation | 4 |
| Conestoga Eye | Amblyopia | 3 |
| Amish Research Clinic | Diabetes Type 2, Hyperglycemia, Obesity | 2 |
| Penn Medicine Lancaster General | AV Block, Heart Failure, Heart Failure With Reduced Ejection Fraction | 2 |
| US Digestive Health | Liver Fibrosis, Metabolic Dysfunction Associated Steatohepatitis, Metabolic Dysfunction Associated Steatohepatitis (MASH) | 2 |
| University of Maryland Amish Research Clinic | Diabetes, Ethics, Familial Hypercholesterolemia | 2 |
| Advanced Surgery Center of Lancaster | Lumbar Spinal Stenosis | 1 |
| Ann B Barshinger Cancer Institute | Ovarian Cancer | 1 |
| Ann B. Barshinger Cancer Institute | Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer | 1 |
| Cardiology Care for Children | Cardiomyopathy | 1 |
| Clinical Trial Site | Transthyretin Amyloidosis With Cardiomyopathy | 1 |
| Heart Grp_ Lancaster Gen Hlth | Heart Failure | 1 |
| Lancaster Gen Health | Lumbar Spinal Stenosis | 1 |
| Lancaster General Health - Ann B. Barshinger Cancer Institute | Cervical Cancer, Endometrial Cancer, Uterine Cancer | 1 |
| Local Institution - 0288 | Non-Small Cell Lung Cancer (NSCLC) | 1 |
| Penn Lancaster General Health Research Institute | Percutaneous Coronary Intervention, Peripheral Endovascular Intervention | 1 |
| Penn Med. Lancaster Gen Hospital | Heart Failure, Obesity | 1 |
| Penn Medicine - Lancaster General Hospital | Metastatic Breast Cancer | 1 |
| Penn Medicine Lancaster General Hospital - Ann B. Barshinger Cancer Institute | Neoplasm Metastasis, Ureteral Neoplasms, Urinary Bladder Neoplasms | 1 |
| Penn Medicine/ Lancaster General Health | Arthroplasty Complications, Infection, Knee Disease | 1 |
Active & Upcoming Studies in Lancaster (2026)
Recruiting trials in Lancaster grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (37 active studies)
- A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202) · Phase 3 · Bristol-Myers Squibb
- A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract · Phase 3 · Eli Lilly and Company
Cardiovascular (13 active studies)
- A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity · Phase 3 · Novo Nordisk A/S
- Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention · Phase 4 · Duke University
Diabetes & metabolic (3 active studies)
- Pharmacogenetics of Response to Sitagliptin (PRS) · Phase 4 · University of Maryland, Baltimore
- A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity · Phase 3 · Novo Nordisk A/S
Mental health & behavior (1 active study)
- E-Mindfulness Approaches for Living After Breast Cancer · Phase 3 · NRG Oncology
Neurology & pain (1 active study)
- MyStroke for Stroke Survivors and Caregivers · University of Pennsylvania
Pediatric (1 active study)
- Vancomycin Reduction Practices (VRP) in the NICU · Children's Hospital of Philadelphia
Common conditions studied in Lancaster
- Heart Failure (7 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Amblyopia (3 active studies). Recruiting Amblyopia studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Breast Cancer (3 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Neoplasm Metastasis (3 active studies). Recruiting Neoplasm Metastasis studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Non-small Cell Lung Cancer (3 active studies). Lung cancer research focuses on targeted therapies for specific mutations such as EGFR, ALK, and KRAS, alongside immunotherapy regimens.
- Prostate Cancer (3 active studies). Prostate cancer studies test next-generation hormone therapies, PARP inhibitors, and radioligand treatments for both localized and advanced disease.
Leading research sponsors in Lancaster
- NRG Oncology
- Abramson Cancer Center at Penn Medicine
- Bristol-Myers Squibb
- University of Maryland, Baltimore
- Eli Lilly and Company
Local regulations and guidelines
Clinical trials in Pennsylvania are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Pennsylvania research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Lancaster. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Lancaster
Hipa.ai aggregates every recruiting study in Lancaster from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Lancaster?
There are approximately 80 recruiting clinical trials in Lancaster, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Lancaster pay participants?
Most recruiting trials in Lancaster compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Lancaster?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Lancaster?
The most common conditions under active study in Lancaster include Heart Failure (7), Amblyopia (3), Breast Cancer (3), Neoplasm Metastasis (3), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Lancaster?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Lancaster on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Lancaster?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Lancaster?
Recruiting research sites in Lancaster include Lancaster General Hospital, Lancaster General Ann B Barshinger Cancer Institute, Keystone Urology Specialists, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Lancaster right now?
The largest active categories in Lancaster are Cancer & tumors (37), Cardiovascular (13), Diabetes & metabolic (3). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.