Vancomycin Reduction Practices (VRP) in the NICU

Conditions

• Antibiotic Stewardship
• Neonatal Sepsis, Late-Onset
• Vancomycin

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• External Facilitation — BEHAVIORAL
  Designated external facilitators will conduct monthly meetings with local champions at each site. Designated facilitators will follow the developed facilitation guide, that includes content area to cover in each meeting, case scenarios as examples, and tips on how to communicate and support the internal facilitators. The goal is to enable problem-solving and support the local champion in implementing VRP with fidelity

Study Details

This multi-center, cluster randomized study aimed at improving implementation of vancomycin reducing practices (VRP) in neonatal intensive care units (NICUs). Sites will be recruited and randomized to receive either external facilitation or no external facilitation to assess the effect on center-level fidelity to the core components of VRP implementation. Interventions available to both study arms are directed at hospital staff and includes identification of local champions, educational outreach, unit-level audit \& feedback, and use of a clinical decision support tool.

Key Dates

Start date

Jun 2, 2025

Status verified

Jun 2025

Primary completion

Sep 30, 2027

Completion

Sep 30, 2027

Study Design

Enrollment

13 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Arms

• Experimental: Sites receiving external facilitation
  Sites will receive guidance from an external facilitator to support uptake of the VRP.
• No Intervention: Sites not receiving external facilitation
  Sites will not receive guidance from an external facilitator.

Primary Outcome Measure

Fidelity of VRP use [ Time Frame: 2.5 years - From beginning of implementation phase to the end of the sustainment phase ]

Central Contacts

• Kayla Gilpin
  215-573-3976
  [email protected]
• Morgan Gabbert
  267-233-3150
  [email protected]

Locations (13)

Find similar trials in Modesto, CA

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