Pharmacogenetics of Response to Sitagliptin (PRS)

Part of paid clinical trials in Lancaster, Pennsylvania.

Sponsor
University of Maryland, Baltimore
Study ID
NCT06813014
Phase
PHASE4
Status
Not Yet Recruiting

Notify me when recruiting opens

Save your spot on the interest list for this study. We'll keep your details with this study so our team can follow up when recruiting opens.

Not yet recruiting

Add your contact details and location so we can keep your interest tied to this study.

Conditions

  • Diabetes

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Oral Glucose Tolerance Test — PROCEDURE
    Three hour glucose tolerance test

Study Details

This is a research study to find out how different people respond to a medication called sitagliptin. Sitagliptin is an FDA approved medication that is used to treat diabetes. We are asking for healthy, non-diabetic volunteers to participate in this 7-week study. If you agree to participate, you will take part in 2 clinic visits that are 4-6 weeks apart. At the clinic visits you will have an oral glucose tolerance test (OGTT) and other blood tests to see how your body processes glucose (sugar). An OGTT is a test in which your drink glucose and then blood samples are taken afterward at specific time points to measure glucose and insulin in your blood. Each clinic visit will last about 5 hours.

Key Dates

Start date
Dec 31, 2026
Status verified
Feb 2026
Primary completion
Nov 30, 2031
Completion
Dec 31, 2032

Study Design

Enrollment
400 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Sitagliptin
    Sitagliptin 100 mg given 2 hours prior to the oral glucose tolerance test
  • Placebo Comparator: Placebo
    Placebo given 2 hours prior to the oral glucose tolerance test

Primary Outcome Measure

Sitagliptin-induced enhancement of early insulin secretion [ Time Frame: 6 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Maryland Amish Research ClinicLancasterPennsylvania17602-

Find similar trials in Lancaster, PA

By research site
University of Maryland Amish Research Clinic· Lancaster, PA

Related Studies