A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

Part of paid clinical trials in Mobile, Alabama.

Sponsor
Incyte Corporation
Study ID
NCT07023627
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Interventions

  • INCB123667 — DRUG
    Administered orally twice daily (BID).

Study Details

This study will evaluate the safety and efficacy of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer (PROC) With Cyclin E1 Overexpression.

Key Dates

Start date
Nov 12, 2025
Status verified
May 2026
Primary completion
Apr 27, 2027
Completion
Oct 24, 2027

Study Design

Enrollment
160 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Cohort 1
    INCB123667 will be administered at the protocol defined dose based on their tumor cyclin E1 expression levels as defined in the protocol.
  • Experimental: Cohort 2
    INCB123667 will be administered at the protocol defined dose based on their tumor cyclin E1 expression levels as defined in the protocol.
  • Experimental: Cohort 3
    INCB123667 will be administered at the protocol defined dose based on their tumor cyclin E1 expression levels as defined in the protocol.

Primary Outcome Measure

Objective Response by IRC [ Time Frame: Up to 2 years ]

Central Contacts

Locations (42)

FacilityCityStateZIPSite coordinators
Usa Health Mitchell Cancer InstituteMobileAlabama36604-
University of California, Los Angeles Medical CenterLos AngelesCalifornia90024-6995-
Scripps Healthscripps Mercy Hospital Prebys Cancer CenterSan DiegoCalifornia92103-
Medstar Georgetown University HospitalWashington D.C.District of Columbia20010-
Florida Cancer Specialists & Research InstituteFort MyersFlorida33901-
Sylvester Comprehensive Cancer CenterMiamiFlorida33136-
Mount Sinai Comprehensive Cancer CenterMiami BeachFlorida33140-
Florida Cancer Specialists & Research InstituteWest Palm BeachFlorida33401-
Northeast Georgia Medical Center GainesvilleGainesvilleGeorgia30501-
Parkview Research CenterFort WayneIndiana46845-
Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolisIndiana46202-
University of Iowa Hospital and ClinicsIowa CityIowa52242-1009-
Norton Cancer InstituteLouisvilleKentucky40207-
Trials365, LlcShreveportLouisiana71103-
Greater Baltimore Medical CenterBaltimoreMaryland21204-
Massachusetts General HospitalBostonMassachusetts02114-
Umass Memorial Medical Center, Inc.WorcesterMassachusetts01605-
University of Michigan Health SystemAnn ArborMichigan48109-
Minnesota Oncology-MinneapolisMinneapolisMinnesota55404-
University of Mississippi Medical CenterJacksonMississippi39216-
Washington UniversitySt LouisMissouri63110-
St. Vincent Regional Hospital - West End ClinicBillingsMontana59106-
Nebraska Methodist HospitalOmahaNebraska68114-
John Theurer Cancer Center, Hackensack University Medical CenterHackensackNew Jersey07601-
Laura and Isaac Perlmutter Cancer CenterNew YorkNew York10016-
University of Rochester, James P. Wilmot Cancer CenterRochesterNew York14642-
State University of New York Upstate Medical UniveSyracuseNew York13210-
Oncology Hematology Care, IncCincinnatiOhio45242-
The Mark H Zangmeister Cancer Center OhioColumbusOhio43219-
The Ohio State University Wexner Medical Center Division of Gynecologic OncologyHilliardOhio43026-
Penn State College of MedicineHersheyPennsylvania17033-
Asplundh Cancer Pavilion - Thomas JeffersonWillow GrovePennsylvania19090-
Medical University of South CarolinaCharlestonSouth Carolina29425-
Texas Oncology-Austin CenterAustinTexas78731-
Houston Methodist Cancer CenterHoustonTexas77030-
Texas Oncology-San Antonio Medical Center PharmacySan AntonioTexas78229-
Texas Oncology-TylerTylerTexas75702-
Utah Cancer SpecialistsSalt Lake CityUtah84106-
Virginia Cancer SpecialistsFairfaxVirginia22031-
Carilion ClinicRoanokeVirginia24016-4962-
West Virginia UniversityMorgantownWest Virginia26506-
Froedtert & the Medical College of WisconsinMilwaukeeWisconsin53226-

Find similar trials in Mobile, AL

By condition
Ovarian cancer
By specialty
OncologyGynecologic oncologyWomen's health
By research site
Usa Health Mitchell Cancer Institute· Mobile, ALUniversity of California, Los Angeles Medical Center· Los Angeles, CAScripps Healthscripps Mercy Hospital Prebys Cancer Center· San Diego, CAMedstar Georgetown University Hospital· Washington D.C., DCFlorida Cancer Specialists & Research Institute· Fort Myers, FLSylvester Comprehensive Cancer Center· Miami, FL

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