Impact of Electronic Cigarette Temperature and Solvent on Biomarkers

Part of paid clinical trials in Hershey, Pennsylvania.

Sponsor
Milton S. Hershey Medical Center
Study ID
NCT07612696
Status
Not Yet Recruiting

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Conditions

  • Electronic Cigarettes
  • Oxidative Stress
  • Tobacco Use

Eligibility Criteria

Sex
ALL
Age
21 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • High temperature wattage setting on electronic cigarette — OTHER
    Study provided electronic cigarette will be set to a high wattage resulting in a higher usage temperature (275 C)
  • Low temperature wattage setting on electronic cigarette — OTHER
    Study provided electronic cigarette will be set to a low wattage resulting in a lower usage temperature (200 C)
  • High concentration of Propylene Glycol — OTHER
    Study provided electronic cigarette liquid will have a higher percentage of propylene glycol (90%)
  • Low concentration of Propylene Glycol — OTHER
    Study provided electronic cigarette liquid will have a higher percentage of propylene glycol (10%)

Study Details

This project seeks to determine how e-cigarette (EC) physical design features, including those that allow the user to manipulate the quality and quantity of aerosols, affect exposure and toxicity from oxidants and other aerosol constituents.

Key Dates

Start date
Jun 30, 2026
Status verified
May 2026
Primary completion
Aug 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
50 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: High Wattage/High Propylene Glycol
    High temperature and high propylene glycol concentration
  • Experimental: Low Wattage/Low Propylene Glycol
    Low temperature and low propylene glycol concentration
  • Experimental: High Wattage/Low Propylene Glycol
    High temperature and low propylene glycol concentration
  • Experimental: Low Wattage/High Propylene Glycol
    Low temperature and high propylene glycol concentration

Primary Outcome Measure

8-isoprostane in Exhaled Breath Condensate [ Time Frame: Baseline prior to study product use in Phase 1 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Penn State College of MedicineHersheyPennsylvania17033
Kenneth Houser, MS
[email protected]
717-531-5473
Zachary Bitzer, Ph.D. (PRINCIPAL_INVESTIGATOR)

Find similar trials in Hershey, PA

By research site
Penn State College of Medicine· Hershey, PA

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