Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior

Part of paid clinical trials in University Park, Pennsylvania.

Sponsor
Penn State University
Study ID
NCT05572671
Status
Recruiting
Apply to this trial

Conditions

  • Smoking
  • Tobacco Use

Eligibility Criteria

Sex
ALL
Age
21 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Laboratory task modeling smoking lapse behavior — BEHAVIORAL
    Participants will complete a task (the behavioral intervention) designed to model smoking lapse behavior in the laboratory; during the task, they will be given the option of delaying smoking in exchange for monetary reinforcement.

Study Details

Most attempts to quit smoking end in relapse, or a return to regular smoking. One of the biggest threats to cessation is a lapse (i.e., any cigarette use during a quit attempt). Thus, characterizing why lapses occur is essential to understanding and preventing smoking relapse. Functional magnetic resonance imaging (fMRI) is a promising method for characterizing the psychological processes that lead to smoking lapses because it provides a way to measures patterns of brain activity thought to reflect relevant mental processes as they change over time. However, methodological issues have hindered the ability to capitalize on this potential and prevented an understanding of how brain activity and corresponding psychological processes unfold in the critical moments that immediately precede a smoking lapse. The proposed project will address this knowledge gap using a novel fMRI paradigm adapted from a well-validated behavioral lapse task. The goals of the project are to characterize changes in brain activity that lead up to a lapse and to investigate how these changes are related to concurrent affect and subsequent cigarette use.

Key Dates

Start date
Apr 4, 2023
Status verified
Mar 2026
Primary completion
Jul 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
150 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: fMRI smoking lapse task

Primary Outcome Measure

Blood-oxygen-level dependent (BOLD) signal [ Time Frame: Day 2 (Visit 2) ]

Locations (1)

FacilityCityStateZIPSite coordinators
The Pennsylvania State UniversityUniversity ParkPennsylvania16870
Stephen Wilson
[email protected]
8144047628

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The Pennsylvania State University· University Park, PA

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