Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension

Part of paid clinical trials in Hershey, Pennsylvania.

Sponsor
Milton S. Hershey Medical Center
Study ID
NCT06482853
Phase
EARLY_PHASE1
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Angiotensin-(1-7) — DRUG
    This is a biologically active endogenous angiotensin peptide that may play an important role in regulation of blood pressure.
  • Saline — DRUG
    Saline will be used as the placebo comparator.

Study Details

Obesity is a global health concern that is associated with high blood pressure and an increased risk for developing cardiovascular disease. The purpose of this study is to find out if the investigational drug angiotensin-(1-7) can improve cardiovascular health in people with obesity and high blood pressure.

Key Dates

Start date
Jan 23, 2025
Status verified
Sep 2025
Primary completion
Mar 31, 2029
Completion
Mar 31, 2029

Study Design

Enrollment
52 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Angiotensin-(1-7)
    Participants will receive intravenous angiotensin-(1-7) at one study visit for a total of 120 minutes. Angiotensin-(1-7) will be given in escalating doses of 2 ng/kg/min, 4 ng/kg/min, and 8 ng/kg/min. Each of these doses will be infused for 10 minutes. Following this 30 minute dose escalation period, angiotensin-(1-7) will be given at 8 ng/kg/min for an additional 90 minutes. Infusion rates will be calculated for each patient based on body mass.
  • Placebo Comparator: Saline
    Participants receive intravenous saline at one study visit for a total of 120 minutes. The volume of saline will match the volume of angiotensin-(1-7) infused. Infusion rates will be calculated for each patient based on body mass.

Primary Outcome Measure

Change in Muscle Sympathetic Nerve Burst Rate [ Time Frame: 120 minutes ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Penn State Milton S. Hershey Medical CenterHersheyPennsylvania17033
Amy Arnold, PhD
[email protected]
717-531-3674
Urs A Leuenberger, MD (SUB_INVESTIGATOR)
Aimee Cauffman, RN (SUB_INVESTIGATOR)
Cheryl Blaha, RN (SUB_INVESTIGATOR)
Jian Cui, PhD (SUB_INVESTIGATOR)
Takuto Hamaoka, MD, PhD (SUB_INVESTIGATOR)
Mami Hamaoka, MD (SUB_INVESTIGATOR)

Find similar trials in Hershey, PA

By condition
Hypertension (high blood pressure)Obesity / overweight
By specialty
CardiologyHeart diseaseEndocrinologyMetabolic healthWeight loss
By research site
Penn State Milton S. Hershey Medical Center· Hershey, PA

Related Studies