Paid Clinical Trials in Columbia, MO

As of June 2026, 258 paid clinical trials are recruiting in Columbia, Missouri. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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258 clinical trials

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Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

for Castration-Resistant Prostate Carcinoma

107 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06632977·Phase 2·Recruiting

Apply to this trial

Propranolol in Primary Progressive Aphasia

for Aphasia, Primary Progressive

1 location in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 50+

Code: NCT06066710·EARLY_Phase 1·Recruiting

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Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

for Non-small Cell Lung Cancer

36 locations incl. Anchorage

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT06712316·Phase 2, Phase 3·Recruiting

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Study of Fetal Health Outcomes: Working With a Missouri E-telehealth Platform (The SHOW-ME Study)

for Pregnancy

3 locations incl. Columbia

Sponsor: University of Missouri-Columbia

Sex: Female·Age: 18+

Code: NCT06741735·Recruiting

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RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE

for Osteoporosis

23 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 50+

Code: NCT06455085·Recruiting

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Improving Participation After Stroke Self-Management-Rehabilitation

for Stroke

1 location in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 45 - 85

Code: NCT06588647·Recruiting

Apply to this trial

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

for Anatomic Stage IV Breast Cancer AJCC v8

256 locations incl. Tucson

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500455·Phase 3·Recruiting

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A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma

for Asthma

85 locations incl. Phoenix

Sponsor: Teva Branded Pharmaceutical Products R&D LLC

Sex: All·Age: 12+

Code: NCT06664619·Phase 3·Recruiting

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC

for Non-squamous Non-small Cell Lung Cancer

Drug: Rilvegostomig

77 locations incl. Mobile

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06627647·Phase 3·Recruiting

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A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

for Hormone Receptor Positive HER-2 Negative Breast Cancer

35 locations incl. Birmingham

Sponsor: Puma Biotechnology, Inc.

Sex: All·Age: 18+

Code: NCT06369285·Phase 2·Recruiting

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

Drug: Rilvegostomig

74 locations incl. Tucson

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06692738·Phase 3·Recruiting

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Early Internal Fixation Versus NonOperative Care With Early Rehabilitation for LC1 Fragility Fractures of the Pelvis

for Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring

12 locations incl. Phoenix

Sponsor: University of Southern California

Sex: All·Age: 60+

Code: NCT06496867·Recruiting

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Mental Processes for Rating Pain Intensity

for Pain

1 location in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 18+

Code: NCT06822764·Enrolling By Invitation

LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis

for Metabolic Dysfunction Associated Steatohepatitis

Drug: Survodutide

125 locations incl. Peoria

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06632457·Phase 3·Recruiting

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Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study

for Chronic Subdural Hematoma

31 locations incl. Phoenix

Sponsor: The University of Texas Medical Branch, Galveston

Sex: All·Age: 40 - 90

Code: NCT06347796·Recruiting

Apply to this trial

Cognitive Rehabilitation Following Breast Cancer Treatment

for Breast Cancer Female

1 location in Columbia

Sponsor: University of Missouri-Columbia

Sex: Female·Age: 20 - 75

Code: NCT06545045·Recruiting

Apply to this trial

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

for Carcinoma, Non-Small-Cell Lung

Drug: Intismeran autogene

48 locations incl. Gilbert

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06623422·Phase 3·Recruiting

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Laser In Situ Fenestration Study

for Aortic Aneurysm

1 location in Columbia

Sponsor: Jonathan Bath

Sex: All·Age: 18+

Code: NCT06411990·Recruiting

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NeuroControl of Nicotine Dependence

for Nicotine Dependence

1 location in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06347055·Recruiting

Apply to this trial

Development of Novel Psychological Assessment Tools and Anxiety Intervention for Phenylketonuria

for Phenylketonurias

1 location in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 10 - 17

Code: NCT06560736·Recruiting

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Early Neurovascular Adaptations in Aging Women

for Women

1 location in Columbia

Sponsor: University of Missouri-Columbia

Sex: Female·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06520982·EARLY_Phase 1·Recruiting

Apply to this trial

LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis

for Metabolic Dysfunction Associated Steatohepatitis (MASH)

Drug: Survodutide

165 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06632444·Phase 3·Recruiting

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A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

for NASH - Nonalcoholic Steatohepatitis

Drug: Efruxifermin

168 locations incl. Birmingham

Sponsor: Akero Therapeutics, Inc

Sex: All·Age: 18 - 80

Code: NCT06528314·Phase 3·Recruiting

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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

for Crohn's Disease

64 locations incl. Dothan

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT06548542·Phase 2·Recruiting

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KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Generalized Myasthenia Gravis

for Myasthenia Gravis

8 locations incl. Orange

Sponsor: Kyverna Therapeutics

Sex: All·Age: 18 - 75

Code: NCT06193889·Phase 2, Phase 3·Recruiting

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Intensive Pediatric Group Intervention

for Cerebral Palsy

1 location in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 7 - 17

Code: NCT06527469·Enrolling By Invitation

Empagliflozin Reversal of Arterial StiffnEss in Aging

for Aging

Drug: Empagliflozin

1 location in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 60 - 80·Accepts healthy volunteers

Code: NCT06506422·Phase 2, Phase 3·Recruiting

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Long-term Follow-up of Gene Therapy for Radiation-Induced Xerostomia

for Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

7 locations incl. Gilbert

Sponsor: MeiraGTx, LLC

Sex: All·Age: 18+

Code: NCT06544798·Phase 2·Enrolling By Invitation

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity

for Obesity

1 location in Columbia

Sponsor: Bettina Mittendorfer

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06335771·Recruiting

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Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

for Obesity

1 location in Columbia

Sponsor: Bettina Mittendorfer

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06571474·Recruiting

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Remote Sensing for ADRD-Specific Activities Identification in Older Adults

for Alzheimer Disease and Related Dementias (ADRD)

1 location in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT07120347·Recruiting

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Long-term Safety and Tolerability of BHV-7000

for Focal Epilepsy

115 locations incl. Birmingham

Sponsor: Biohaven Therapeutics Ltd.

Sex: All·Age: 18 - 75

Code: NCT06443463·Phase 2·Enrolling By Invitation

Study to Assess the Efficacy and Safety of Iovera®° System in Subjects With Upper Extremity Spasticity

for Spasticity, Cerebral or Spinal Condition

18 locations incl. Downey

Sponsor: Pacira Pharmaceuticals, Inc

Sex: All·Age: 18+

Code: NCT06340451·Recruiting

Apply to this trial

CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial

for Trauma

15 locations incl. Tucson

Sponsor: Jason Sperry

Sex: All·Age: 18 - 90

Code: NCT05958342·Phase 2·Recruiting

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ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

for Cardiovascular Risk

Drug: Ziltivekimab

208 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT06118281·Phase 3·Recruiting

Apply to this trial

No DIET Trial: Dogmatic Interruption of Enteral nuTrition

for Gastrostomy

1 location in Columbia

Sponsor: Jeffrey Coughenour

Sex: All·Age: 18+

Code: NCT06431048·Enrolling By Invitation

Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL

for Large B-cell Lymphoma

60 locations incl. Gilbert

Sponsor: Allogene Therapeutics

Sex: All·Age: 18+

Code: NCT06500273·Phase 2·Recruiting

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Studying Warmed Lidocaine for Increased Analgesic Effect During Intravitreal Injections

for Pain Intensity Assessment

1 location in Columbia

Sponsor: Balaji

Sex: All·Age: All ages

Code: NCT06962709·Enrolling By Invitation

Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome

for Diet Intervention

1 location in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06433115·Recruiting

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Prospective Clinical Assessment Study in Children With Hypochondroplasia

for Hypochondroplasia

8 locations incl. Oakland

Sponsor: QED Therapeutics, a BridgeBio company

Sex: All·Age: 30 Months - 16

Code: NCT06410976·Recruiting

Apply to this trial