A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC

Part of paid clinical trials in Mobile, Alabama.

Sponsor
AstraZeneca
Study ID
NCT06627647
Phase
PHASE3
Status
Recruiting
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Conditions

  • Non-squamous Non-small Cell Lung Cancer

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Rilvegostomig — DRUG
    Administered as one intravenously (IV) on Day 1 of each 21-day cycle
  • Pembrolizumab — DRUG
    Administered as one intravenously (IV) on Day 1 of each 21-day cycle
  • Carboplatin — DRUG
    Administered as one intravenously (IV) on Day 1 of each 21-day cycle up to 4 cycles
  • Cisplatin — DRUG
    Administered as one intravenously (IV) on Day 1 of each 21-day cycle up to 4 cycles
  • Pemetrexed — DRUG
    Administered as one intravenously (IV) on Day 1 of each 21-day cycle

Study Details

The purpose of ARTEMIDE-Lung03 is to evaluate the efficacy and safety of rilvegostomig compared to pembrolizumab, both in combination with platinum-based doublet chemotherapy, as a first-line treatment of patients with non-squamous mNSCLC whose tumors express PD-L1.

Key Dates

Start date
Nov 27, 2024
Status verified
May 2026
Primary completion
May 10, 2029
Completion
Mar 25, 2030

Study Design

Enrollment
878 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm A
    Rilvegostomig in combination with platinum-based doublet chemotherapy followed by rilvegostomig monotherapy plus pemetrexed in maintenance.
  • Active Comparator: Arm B
    Pembrolizumab in combination with platinum-based doublet chemotherapy followed by pembrolizumab monotherapy plus pemetrexed in maintenance.

Primary Outcome Measure

Overall survival (OS) [ Time Frame: Up to approximately 5 years ]

Central Contacts

Locations (77)

FacilityCityStateZIPSite coordinators
Research SiteMobileAlabama36608-
Research SiteChandlerArizona85224-
Research SitePhoenixArizona85054-
Research SiteAnaheimCalifornia92801-
Research SiteBeverly HillsCalifornia90211-
Research SiteLoma LindaCalifornia92350-
Research SiteRedlandsCalifornia92373-
Research SiteSan DiegoCalifornia92123-
Research SiteSan FranciscoCalifornia94121-
Research SiteSanta RosaCalifornia95403-
Research SiteWalnut CreekCalifornia94598-
Research SiteLone TreeColorado80124-
Research SiteStamfordConnecticut06902-
Research SiteWest HavenConnecticut06516-
Research SiteNewarkDelaware19713-
Research SiteBay PinesFlorida33744-
Research SiteFort LauderdaleFlorida33308-
Research SiteGainesvilleFlorida32610-
Research SiteJacksonvilleFlorida32224-
Research SiteMiamiFlorida33125-
Research SiteOcalaFlorida34474-
Research SiteSt. PetersburgFlorida33709-
Research SiteAtlantaGeorgia30342-
Research SiteBoiseIdaho83712-
Research SiteChicagoIllinois60637-
Research SiteDecaturIllinois62526-
Research SiteHinsdaleIllinois60521-
Research SiteQuincyIllinois62305-
Research SiteRockfordIllinois61114-
Research SiteWaterlooIowa50702-
Research SiteLexingtonKentucky40509-
Research SiteLexingtonKentucky40536-
Research SiteLouisvilleKentucky40207-
Research SiteAlexandriaLouisiana71301-
Research SiteBaton RougeLouisiana70808-
Research SiteShreveportLouisiana71103-
Research SiteShreveportLouisiana71105-
Research SiteSouth PortlandMaine04106-
Research SiteBaltimoreMaryland21202-
Research SiteGrand RapidsMichigan49503-
Research SiteDuluthMinnesota55805-
Research SiteRochesterMinnesota55905-
Research SiteSaint PaulMinnesota55102-
Research SiteBridgetonMissouri63044-
Research SiteColumbiaMissouri65212-
Research SiteLincolnNebraska68506-
Research SiteCamdenNew Jersey08103-
Research SiteBuffaloNew York14221-
Research SiteWestburyNew York11590-
Research SiteCantonOhio44710-
Research SiteMedfordOregon97504-
Research SitePortlandOregon97239-
Research SiteSalemOregon97301-
Research SitePittsburghPennsylvania15212-
Research SiteYorkPennsylvania17403-
Research SiteProvidenceRhode Island02903-
Research SitePierreSouth Dakota57501-
Research SiteSioux FallsSouth Dakota57105-
Research SiteChattanoogaTennessee37404-
Research SiteNashvilleTennessee37203-
Research SiteFort WorthTexas76104-
Research SiteHoustonTexas77090-
Research SiteIrvingTexas75063-
Research SiteKingwoodTexas77339-
Research SiteLubbockTexas79410-
Research SitePalestineTexas75801-
Research SiteRound RockTexas78665-
Research SiteFairfaxVirginia22031-
Research SiteNorfolkVirginia23502-
Research SiteRoanokeVirginia24014-
Research SiteSeattleWashington98101-
Research SiteSeattleWashington98104-
Research SiteSilverdaleWashington98383-
Research SiteSpokaneWashington99208-
Research SiteTacomaWashington98405-
Research SiteWenatcheeWashington98801-
Research SiteLa CrosseWisconsin54601-

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