A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

Part of paid clinical trials in Tucson, Arizona.

Sponsor
AstraZeneca
Study ID
NCT06692738
Phase
PHASE3
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Rilvegostomig — DRUG
    Administered intravenously (IV) on Day 1 of each 21-day cycle
  • Pembrolizumab — DRUG
    Administered intravenously (IV) on Day 1 of each 21-day cycle
  • Carboplatin — DRUG
    Administered intravenously (IV) on Day 1 of each 21-day cycle up to 4 cycles
  • Paclitaxel — DRUG
    Administered intravenously (IV) on Day 1 of each 21-day cycle up to 4 cycles
  • Nab-paclitaxel — DRUG
    Administered intravenously (IV) on Days 1, 8, and 15 of each 21-day cycle up to 4 cycles

Study Details

The purpose of ARTEMIDE-Lung02 is to assess the efficacy and safety of rilvegostomig in combination with platinum-based chemotherapy for the first-line (1L) treatment of patients with metastatic squamous non-small cell lung cancer (mNSCLC) whose tumors express programmed death-ligand 1 (PD-L1).

Key Dates

Start date
Nov 18, 2024
Status verified
Jun 2026
Primary completion
Feb 5, 2029
Completion
Oct 8, 2029

Study Design

Enrollment
880 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm A
    Rilvegostomig in combination with carboplatin and paclitaxel or nab-paclitaxel followed by rilvegostomig
  • Active Comparator: Arm B
    Pembrolizumab in combination with carboplatin and paclitaxel or nab-paclitaxel followed by pembrolizumab

Primary Outcome Measure

Overall survival (OS) [ Time Frame: Up to approximately 5 years ]

Central Contacts

Locations (74)

FacilityCityStateZIPSite coordinators
Research SiteTucsonArizona85724-
Research SiteSpringdaleArkansas72762-
Research SiteAnaheimCalifornia92801-
Research SiteBeverly HillsCalifornia90211-
Research SiteLoma LindaCalifornia92354-
Research SiteLos AlamitosCalifornia90720-
Research SiteRedlandsCalifornia92373-
Research SiteSan FranciscoCalifornia94121-
Research SiteWalnut CreekCalifornia94598-
Research SiteWest HavenConnecticut06516-
Research SiteNewarkDelaware19713-
Research SiteBay PinesFlorida33744-
Research SiteFort LauderdaleFlorida33308-
Research SiteGainesvilleFlorida32608-
Research SiteGainesvilleFlorida32610-
Research SiteJacksonvilleFlorida32224-
Research SiteAthensGeorgia30607-
Research SiteAtlantaGeorgia30341-
Research SiteBoiseIdaho83712-
Research SiteChicagoIllinois60637-
Research SiteDecaturIllinois62526-
Research SiteHinsdaleIllinois60521-
Research SiteQuincyIllinois62301-
Research SiteRockfordIllinois61114-
Research SiteFort WayneIndiana46845-
Research SiteWaterlooIowa50702-
Research SiteLexingtonKentucky40509-
Research SiteLexingtonKentucky40536-
Research SiteLouisvilleKentucky40202-
Research SiteLouisvilleKentucky40207-
Research SiteAlexandriaLouisiana71301-
Research SiteBaton RougeLouisiana70808-
Research SiteCovingtonLouisiana70433-
Research SiteShreveportLouisiana71103-
Research SiteShreveportLouisiana71105-
Research SiteScarboroughMaine04074-
Research SiteBaltimoreMaryland21202-
Research SiteBethesdaMaryland20817-
Research SiteDetroitMichigan48202-
Research SiteGrand RapidsMichigan49503-
Research SiteDuluthMinnesota55802-
Research SiteRochesterMinnesota55905-
Research SiteBridgetonMissouri63044-
Research SiteColumbiaMissouri65212-
Research SiteKansas CityMissouri64108-
Research SiteLincolnNebraska68506-
Research SiteCamdenNew Jersey08103-
Research SiteBuffaloNew York14221-
Research SiteEast SyracuseNew York13057-
Research SiteWestburyNew York11590-
Research SiteWilsonNorth Carolina27893-
Research SiteGrand ForksNorth Dakota58201-
Research SiteCincinnatiOhio45267-
Research SiteBendOregon97701-
Research SiteMedfordOregon97504-
Research SiteSalemOregon97301-
Research SiteHersheyPennsylvania17033-
Research SiteYorkPennsylvania17403-
Research SiteSioux FallsSouth Dakota57105-
Research SiteChattanoogaTennessee37404-
Research SiteNashvilleTennessee37203-
Research SiteFort WorthTexas76104-
Research SiteHoustonTexas77090-
Research SiteKingwoodTexas77339-
Research SiteLubbockTexas79410-
Research SiteRound RockTexas78665-
Research SiteFairfaxVirginia22031-
Research SiteFredericksburgVirginia22408-
Research SiteOlympiaWashington98506-
Research SiteSeattleWashington98101-
Research SiteSilverdaleWashington98383-
Research SiteSpokaneWashington99208-
Research SiteTacomaWashington98405-
Research SiteWenatcheeWashington98801-

Find similar trials in Tucson, AZ

By condition
Lung cancer
By specialty
OncologyLung oncologyLung disease
By research site
Research Site· Tucson, AZResearch Site· Springdale, ARResearch Site· Anaheim, CAResearch Site· Beverly Hills, CAResearch Site· Loma Linda, CAResearch Site· Los Alamitos, CA

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