Early Neurovascular Adaptations in Aging Women

Part of paid clinical trials in Columbia, Missouri.

Sponsor
University of Missouri-Columbia
Study ID
NCT06520982
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Aging
  • Blood Flow
  • Sympathetic Nervous System
  • Women

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Norepinephrine — DRUG
    Infused intra-arterially in a dose-response fashion
  • Isoproterenol — DRUG
    Infused intra-arterially in a dose-response fashion
  • Acetylcholine — DRUG
    Infused intra-arterially in a dose-response fashion
  • Nitroprusside — DRUG
    Infused intra-arterially in a dose-response fashion
  • Estrogen — DRUG
    Infused intra-arterially

Study Details

Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.

Key Dates

Start date
Sep 20, 2024
Status verified
Nov 2025
Primary completion
Jun 30, 2027
Completion
Jun 30, 2028

Study Design

Enrollment
64 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Other: Women
    Women will be 18-70 years of age

Primary Outcome Measure

Magnitude of forearm blood flow [ Time Frame: Change from baseline during infusion ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Missouri-ColumbiaColumbiaMissouri65211
Jacqueline K Limberg, Ph.D.
[email protected]
573-882-2420

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By research site
University of Missouri-Columbia· Columbia, MO

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