Paid Clinical Trials in Columbia, MO
As of June 2026, 258 paid clinical trials are recruiting in Columbia, Missouri. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Columbia offers studies at sites including University of Missouri for conditions such as Obesity, Healthy, Hypochondroplasia, Aging. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Columbia
Trials by drug in Columbia
Filter results
258 clinical trials
↓ Download CSVA Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism Spectrum Disorder
Growth Hormone Resistance of Beta-cells
Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
Metacognitive Strategy Training Intervention for Transition-Age Youth With Cerebral Palsy
Efficacy, Safety, and Tolerability of Zeleciment Basivarsen (DYNE-101) in Participants With Myotonic Dystrophy Type 1
Talar Osteochondral Lesions With Pilon Fractures
The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.
Open-Label, Long-Term, Extension Study of Infigratinib in Children With Hypochondroplasia
A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared to BFF in Participants of 4 to Less Than 12 Years of Age With Asthma
The Feasibility of a Remote Problem-Solving Intervention for Autistic Adolescents or Young Adults and a Caregiver
Evaluating the Effectiveness of Remote Monitoring for Post-Operative Management of Distal Radius Fractures
A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)
A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)
Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Impact of Sleep Restriction on Blood Pressure Reactivity
Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI)
A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)
Carbo-fix Lateral Plate Devices and Standard Plate-Nail Constructs in Distal Femur Fractures
A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)
Lead Evaluation for Defibrillation and Reliability Post Approval Study
Impact of Phenylalanine Elevations on Brain and Cognition in Adult PKU Carriers
Effects of Grape Consumption on the Immune-Gut Axis in Obesity
A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy
Study of DONQ52 in Active Celiac Disease
A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH)
Pars Healing on MRI
Investigating Cannabis Use Parameters on Anesthesia and Inflammation in Lumbar Spinal Surgeries
Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)
A Study to Evaluate the Efficacy, Safety, and Drug Levels of Deucravacitinib (BMS-986165) in Adolescent Participants With Moderate to Severe Plaque Psoriasis
A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)
A Study to Find Out Whether BI 765423 Has an Effect on Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF) With or Without Standard Treatment
7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)
Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations
Open Pilon With FIBERGRAFT AERIDYAN Matrix Bioactive Glass
Growth Hormone Resistance of Beta-cells A
A Two-Part Phase 3 Study of Sofetabart Mipitecan (LY4170156) in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Part B) Ovarian Cancer
About research studies in Columbia
Columbia has approximately 258 recruiting research studies across a wide range of therapeutic areas. Missouri hosts Washington University School of Medicine in St. Louis and University of Kansas Medical Center's Missouri partners, known for oncology, genomics, and rare-disease research.
Top Research Study Locations in Columbia
Researchers run research studies in Columbia, MO at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Missouri | Hypochondroplasia, Stroke, AAA - Abdominal Aortic Aneurysm | 58 |
| MU Health - University Hospital/Ellis Fischel Cancer Center | Anatomic Stage II Breast Cancer AJCC v8, Breast Cancer, Endometrial Clear Cell Adenocarcinoma | 23 |
| University of Missouri Children's Hospital | Acute Myeloid Leukemia, Ganglioneuroblastoma, Nodular, Metastatic Osteosarcoma | 14 |
| University of Missouri-Columbia | Aging, ART, ASCVD | 14 |
| University of Missouri - Columbia | Tobacco Use Disorder, Aortic Aneurysm, Autism | 12 |
| Missouri Cancer Associates | CRC (Colorectal Cancer), Colon Cancer, Colorectal Cancer | 10 |
| University of Missouri School of Medicine | Healthy, Obesity, Atherosclerosis | 10 |
| University of Missouri Health Care | Amyotrophic Lateral Sclerosis, Focal Epilepsy, Atrial Fibrillation | 9 |
| Missouri Orthopaedic Institute | Cannabis Use, Femoroacetabular Impingement Syndrome, Fragility Fracture | 7 |
| University of Missouri Hospital | Diabetes Mellitus, Fallopian Tube Neoplasms, Gastrostomy | 7 |
| University of Missouri Health System | Ankle Fractures, Cardiovascular Diseases, Cognitive Impairment, Mild | 5 |
| Columbia Orthopedic Group Research | Degenerative Disc Disease, Cervical Disc Disease, Cervical Disc Herniation | 3 |
| NextGen Precision Health Building, Clinical and Translational Science Unit | Aging, Amyotrophic Lateral Sclerosis, Centronuclear Myopathy | 3 |
| The Curators of the University of Missouri | Aortoiliac Occlusive Disease, Diabetic Retinopathy, Epiretinal Membrane | 3 |
| University Hospital | Cannabis Use, Hypotension During Surgery, Postinduction Hypotension | 3 |
| University of Missouri Health System Department of Genetics | Cerebroside Lipidosis Syndrome, Fabry Disease, Gaucher Disease | 3 |
| GI Associates Research, LLC | Celiac Disease, Crohn's Disease, Ulcerative Colitis | 3 |
| Akero Clinical Study Site | MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, NASH - Nonalcoholic Steatohepatitis | 2 |
| GSK Investigational Site | Asthma, HIV Infections | 2 |
| Harry S. Truman Memorial, Columbia, MO | Liver Fibrosis, Nonalcoholic Steatohepatitis, Obesity | 2 |
| ObjectiveHealth-GI Associates Research | Liver Fibrosis, Metabolic Dysfunction Associated Steatohepatitis, Metabolic Dysfunction Associated Steatohepatitis (MASH) | 2 |
| The Curators of the University of Missouri on behalf of University of Missouri Health Care | Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), Spinal Muscular Atrophy (SMA) | 2 |
| University of Missouri - Ellis Fischel | Anatomic Stage IV Breast Cancer AJCC v8, Castration Levels of Testosterone, Elevated CA15-3 or CEA or CA27-29 | 2 |
| University of Missouri - Ellis Fischel Cancer Center | Large B-cell Lymphoma, Lung Cancer | 2 |
| University of Missouri Healthcare | Acute Myocardial Infarction, Chronic Subdural Hematoma | 2 |
Active & Upcoming Studies in Columbia (2026)
Recruiting trials in Columbia grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (64 active studies)
- Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma · Phase 3 · Immuneering Corporation
- A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201) · Phase 3 · Bristol-Myers Squibb
Diabetes & metabolic (19 active studies)
- Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD) · Bettina Mittendorfer
- Growth Hormone Resistance of Beta-cells · University of Missouri-Columbia
Neurology & pain (16 active studies)
- Impact of Sleep Restriction on Blood Pressure Reactivity · University of Missouri-Columbia
- Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI) · University of Missouri-Columbia
Cardiovascular (12 active studies)
- Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD) · Bettina Mittendorfer
- Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator · Phase 4 · University of Rochester
Mental health & behavior (3 active studies)
- Smoking Cessation Behavioral Treatment Study · University of Missouri-Columbia
- A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression · LivaNova
HIV / STI (2 active studies)
- A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study) · Phase 2 · ViiV Healthcare
- Accelerated ART Initiation for PWHIV Who Are Out of Care · Phase 4 · University of Missouri-Columbia
Pediatric (2 active studies)
- Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN) · University of Missouri-Columbia
- Examining the Role of Executive Functioning in Family-Based Intensive Health Behavior and Lifestyle Treatment · University of Missouri-Columbia
Eye & vision (1 active study)
- Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD · Phase 3 · AbbVie
Common conditions studied in Columbia
- Obesity (8 active studies). Obesity trials evaluate GLP-1 and GIP receptor agonists, novel metabolic drugs, and combined lifestyle interventions for sustainable weight loss.
- Healthy (7 active studies). Healthy-volunteer studies examine how new drugs behave in the body, helping researchers understand safety and dosing before later-phase trials.
- Hypochondroplasia (5 active studies). Recruiting Hypochondroplasia studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Aging (4 active studies). Recruiting Aging studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Amyotrophic Lateral Sclerosis (4 active studies). Recruiting Amyotrophic Lateral Sclerosis studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Asthma (4 active studies). Asthma research tests biologic therapies targeting IL-4, IL-5, and TSLP pathways for moderate-to-severe and eosinophilic disease.
Leading research sponsors in Columbia
- University of Missouri-Columbia
- Children's Oncology Group
- NRG Oncology
- National Cancer Institute (NCI)
- AstraZeneca
Local regulations and guidelines
Clinical trials in Missouri are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Missouri research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Columbia. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Columbia
Hipa.ai aggregates every recruiting study in Columbia from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Columbia?
There are approximately 258 recruiting clinical trials in Columbia, Missouri listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Columbia pay participants?
Most recruiting trials in Columbia compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Columbia?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Columbia?
The most common conditions under active study in Columbia include Obesity (8), Healthy (7), Hypochondroplasia (5), Aging (4), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Columbia?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Columbia on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Columbia?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Columbia?
Recruiting research sites in Columbia include University of Missouri, MU Health - University Hospital/Ellis Fischel Cancer Center, University of Missouri Children's Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Columbia right now?
The largest active categories in Columbia are Cancer & tumors (64), Diabetes & metabolic (19), Neurology & pain (16). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.