The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.

Part of paid clinical trials in Columbia, Missouri.

Sponsor
University of Missouri-Columbia
Study ID
NCT07365800
Phase
PHASE4
Status
Enrolling By Invitation

Conditions

  • Spine Surgery

Eligibility Criteria

Sex
ALL
Age
18 Years - 79 Years
Healthy Volunteers
Not accepted

Interventions

  • Methadone-dexmedetomidine-ketamine combination — DRUG
    Combination of Methadone-dexmedetomidine-ketamine administered during spine surgery for intra- and post-operative pain management.

Study Details

This study will investigate whether a combination of three anesthetic medications will reduce intraoperative and postoperative pain in patients undergoing complex spine surgery, and whether it will reduce the use of opioid pain medication after surgery.

Key Dates

Start date
Apr 24, 2026
Status verified
Jun 2026
Primary completion
Dec 31, 2026
Completion
Jun 30, 2027

Study Design

Enrollment
248 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Intervention
    Group receiving the methadone-dexmedetomidine-ketamine medication combination intravenously during anesthesia for complex spine surgery.
  • No Intervention: Routine
    Group that receives routine anesthesia with opioid medications during complex spine surgery.

Primary Outcome Measure

Effect of the MDK combination during surgery on postoperative opioid consumption [ Time Frame: 72 hours postoperatively ]

Locations (1)

FacilityCityStateZIPSite coordinators
University HospitalColumbiaMissouri65212-

Find similar trials in Columbia, MO

By research site
University Hospital· Columbia, MO

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