Effects of Grape Consumption on the Immune-Gut Axis in Obesity

Part of paid clinical trials in Columbia, Missouri.

Sponsor
University of Missouri-Columbia
Study ID
NCT07231484
Status
Recruiting
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Conditions

  • Obesity &Amp; Overweight

Eligibility Criteria

Sex
ALL
Age
30 Years - 45 Years
Healthy Volunteers
Not accepted

Interventions

  • Freeze-dried grape powder — OTHER
    48 g/day oral consumption during the 4-week active period.
  • Placebo powder — OTHER
    Isocaloric placebo matched to grape powder; oral consumption during the 4-week active period.

Study Details

This study is investigating the benefits of whole freeze-dried grape powder consumption on the immune-gut axis in adults with obesity.

Key Dates

Start date
Dec 19, 2025
Status verified
Nov 2025
Primary completion
Dec 20, 2027
Completion
Dec 30, 2027

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Sequence 1: Grape then Placebo
    Whole freeze-dried grape powder for 4 weeks, 4-week washout, then isocaloric placebo powder for 4 weeks.
  • Experimental: Sequence 2: Placebo then Grape
    Isocaloric placebo powder for 4 weeks, 4-week washout, then whole freeze-dried grape powder for 4 weeks.

Primary Outcome Measure

Gut microbial diversity [ Time Frame: Baseline, Week 4, Week 8, Week 12 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Missouri-ColumbiaColumbiaMissouri65211
Caitlyn Winn, MS
[email protected]
207-210-8049
Jaapna Dhillon, PhD (PRINCIPAL_INVESTIGATOR)
Caitlyn Winn, MS (SUB_INVESTIGATOR)

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