Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Immuneering Corporation
Study ID
NCT07562152
Phase
PHASE3
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Atebimetinib — DRUG
    Once daily oral tablets
  • GnP — DRUG
    Standard of care regimen for intravenous infusions of gemcitabine and nab-paclitaxel weekly for three weeks followed by one week without an infusion
  • mGnP — DRUG
    Biweekly intravenous infusions of chemotherapy (gemcitabine and nab-paclitaxel)

Study Details

The purpose of this study is to evaluate the safety and efficacy of atebimetinib in combination with modified GnP compared with SOC GnP alone.

Key Dates

Start date
Jun 30, 2026
Status verified
Jun 2026
Primary completion
Jun 30, 2028
Completion
Feb 28, 2029

Study Design

Enrollment
510 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Atebimetinib + mGnP
    Atebimetinib in combination with modified gemcitabine and nab-paclitaxel for first line pancreatic adenocarcinoma
  • Active Comparator: GnP
    Standard of care gemcitabine and nab-paclitaxel for first line pancreatic adenocarcinoma

Primary Outcome Measure

Overall Survival [ Time Frame: Up to approximately 2 years ]

Central Contacts

Locations (12)

FacilityCityStateZIPSite coordinators
City of HopePhoenixArizona85338
Khaled Abouelezz, MD
[email protected]
City of HopeDuarteCalifornia91010
Jalene Tangen
[email protected]
Piedmont HealthcareAtlantaGeorgia30318
Eyal Meiri, MD
City of HopeChicagoIllinois60099
Jalene Tangen
[email protected]
Missouri Cancer AssociatesColumbiaMissouri65201
Andrew Iliff, MD
Comprehensive Cancer CentersLas VegasNevada89169
Lindsay Kondo
[email protected]
Regional Cancer CareBellevilleNew Jersey07109
Denise Johnstone
[email protected]
NYU Langone HealthNew YorkNew York10016
Taylor Cancer Research CenterMaumeeOhio43537
Stephanie Ambrose
[email protected]
Sarah Cannon Research InstituteNashvilleTennessee37203
Meredith Pelster, MD
[email protected]
Texas Oncology Gulf CoastWebsterTexas77598
Blue Ridge Cancer CareBlacksburgVirginia24060
Natasha Holt
[email protected]

Find similar trials in Phoenix, AZ

By condition
Pancreatic cancer
By specialty
OncologyGI oncology
By research site
City of Hope· Phoenix, AZCity of Hope· Duarte, CAPiedmont Healthcare· Atlanta, GACity of Hope· Chicago, ILMissouri Cancer Associates· Columbia, MOComprehensive Cancer Centers· Las Vegas, NV

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