Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

Conditions

• Atherosclerotic Disease
• Cachexia
• Chronic Kidney Disease(CKD)
• Cystic Fibrosis (CF)
• Diabetes
• Heart Failure
• Hyperparathyroidism
• Hypoparathyroidism
• Ischemic Heart Disease
• MASH
• Obesity and Obesity-related Medical Conditions
• Osteopenia
• Osteoporosis
• Sarcopenia

Eligibility Criteria

Sex

ALL

Age

18 Years - 100 Years

Healthy Volunteers

Accepted

Interventions

• Endothelial cell collection — OTHER
  Participants may opt to have testing performed including blood sampling, urine sampling, intravenous catheter placement with endothelial cell collection, oral glucose tolerance test, consuming a test meal, having imaging performed such as MRI, DEXA, MRS, having adipose (fat) or muscle biopsies, or non-invasive endothelial function testing to investigate use of different assays, different sample treatment approaches to determine optimal conditions that produce the most accurate and reproducible results, and/or repeat testing on different days or with different equipment that measures the same variable.

Study Details

The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research on chronic diseases, nutrition, and metabolism (the process by which a substance is handled in the body) at the University of Missouri. As technology changes and uses new testing methods, it is necessary to compare results from old tests, equipment and devices and new tests, equipment, or devices and the reproducibility of these measurements to make sure the results are accurate. Reproducibility means performing the same test more than once to see if the same results can be achieved each time. This study will look at the validation and reproducibility of tests and laboratory assays in participants who are healthy or affected by relevant endocrine, cardiometabolic, and musculoskeletal disorders.

Key Dates

Start date

Jan 1, 2027

Status verified

Apr 2026

Primary completion

Jul 1, 2030

Completion

Jul 1, 2030

Study Design

Enrollment

100 participants (estimated)

Primary Outcome Measure

Evaluation of the validity and reproducibility of insulin results in the laboratory environment [ Time Frame: through study completion, up to 6 months ]

Central Contacts

• Study coordinator
  573-884-6852
  [email protected]

Locations (1)

Find similar trials in Columbia, MO

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