Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

Part of paid clinical trials in Columbia, Missouri.

Sponsor
University of Missouri-Columbia
Study ID
NCT06417177
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Placebo — DRUG
    Participants will receive a placebo in pill form.
  • Propranolol — DRUG
    Participants will receive oral propranolol (1 mg/kg).
  • Gemtesa — DRUG
    Participants will receive oral gemtesa (75 mg).

Study Details

The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.

Key Dates

Start date
Jun 3, 2024
Status verified
Sep 2025
Primary completion
Jul 31, 2026
Completion
Jul 31, 2026

Study Design

Enrollment
75 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Hypoxia
    Participants will be exposed to hypoxia (low oxygen air) using a mask.
  • Experimental: Cold pressor test
    Participants will be exposed to the cold pressor test (ice water on the foot).
  • Experimental: Hypercapnia
    Participants will be exposed to hypercapnia (high carbon dioxide air) using a mask.

Primary Outcome Measure

Forearm blood flow [ Time Frame: Change from baseline to 5 minutes. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Missouri-ColumbiaColumbiaMissouri65211
Jacqueline K Limberg, Ph.D.
[email protected]
573-882-2420

Find similar trials in Columbia, MO

By condition
Menopause
By specialty
Women's healthFertility
By research site
University of Missouri-Columbia· Columbia, MO

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