Propranolol in Primary Progressive Aphasia

Conditions

• Aphasia, Primary Progressive

Eligibility Criteria

Sex

ALL

Age

50 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Propranolol — DRUG
  Propranolol will be given on a titration schedule in which participants will begin with small doses of the drug and increase to a larger dosage over the course of three weeks. Propranolol will be taken for a total of 9 weeks.
• Magnetic Resonance Imaging (MRI) — DEVICE
  Magnetic Resonance Imaging (MRI) will be performed at 3 Tesla and 7 Tesla, for both propranolol and placebo arms.
• Placebo — DRUG
  Placebo will be given on the same schedule as the propranolol regime.

Study Details

The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure. This research is being done because there are currently no drug treatment options for language impairments and anxiety often experienced by people with Primary Progressive Aphasia.

Key Dates

Start date

Jan 13, 2025

Status verified

Mar 2025

Primary completion

Dec 31, 2026

Completion

Dec 31, 2027

Study Design

Enrollment

30 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Arms

• Experimental: Propanolol and MRI
  Participants will receive propranolol via oral capsule. The drug dosage will be titrated slowly to ensure the drug is tolerated well.
• Placebo Comparator: Placebo and MRI
  Participants will receive placebo via oral capsule.

Primary Outcome Measure

Change in Neuropsychological Assessment Battery Naming Test [ Time Frame: Day 1, 4 Weeks, 8 Weeks, 10 Weeks, 14 Weeks,18 Weeks ]

Central Contacts

• David Beversdorf, MD
  573-882-6081
  [email protected]
• Jessica Call
  573-882-0515
  [email protected]

Locations (1)

Find similar trials in Columbia, MO

Related Studies

• Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered Speech
  Recruiting · Boston University Charles River Campus · Boston, Massachusetts