Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

Part of paid clinical trials in Columbia, Missouri.

Sponsor
Bettina Mittendorfer
Study ID
NCT06571474
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Study Details

The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals. Both groups will have: * screening visit * imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and magnetic resonance spectroscopy \[MRS\] scans) * Overnight visit with intravenous infusion (IV), muscle, and fat tissue biopsies

Key Dates

Start date
Aug 1, 2024
Status verified
Jul 2025
Primary completion
Mar 31, 2028
Completion
Mar 31, 2028

Study Design

Enrollment
60 participants (estimated)

Arms

  • Arm: Lean Individuals
    No intervention will be administered.
  • Arm: Metabolically abnormal obese Individuals
    Obesity with normoglycemia and abnormal liver fat content
  • Arm: Metabolically normal obese Individuals
    Obesity with normoglycemia and normal liver fat content
  • Arm: Individuals with Type 2 Diabetes Mellitus
    Pre-Diagnosed type 2 diabetics

Primary Outcome Measure

Insulin sensitivity [ Time Frame: Within 2 weeks of Clinical Visit ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Missouri School of MedicineColumbiaMissouri65212
Bettina Mittendorfer
[email protected]
573-882-9377

Find similar trials in Columbia, MO

By condition
Type 2 diabetesObesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
University of Missouri School of Medicine· Columbia, MO

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