NeuroControl of Nicotine Dependence

Part of paid clinical trials in Columbia, Missouri.

Sponsor
University of Missouri-Columbia
Study ID
NCT06347055
Status
Recruiting
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Conditions

  • Nicotine Dependence

Eligibility Criteria

Sex
ALL
Age
18 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

  • Repetitive Transcranial Magnetic Stimulation (rTMS) — DEVICE
    Continuous theta burst rTMS

Study Details

The purpose of the study is to examine the effects of continuous theta burst stimulation (cTBS) on different forms of cognitive control in adults who smoke cigarettes, and to determine if the location where cTBS is delivered may help smokers reduce or quit smoking. Participation in the study will take 3-weeks over 4 visits, with a total time commitment of approximately 12 hours.

Key Dates

Start date
Oct 1, 2024
Status verified
Sep 2024
Primary completion
Mar 25, 2030
Completion
Apr 30, 2030

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: cTBS to Ventrolateral Prefrontal Cortex
    Continuous theta-burst stimulation (cTBS), a form of repetitive transcranial magnetic stimulation (rTMS), affects brain areas stimulated directly underneath the scalp and brain areas that are functionally connected. cTBS will be applied to the ventrolateral prefrontal cortex.
  • Experimental: cTBS to Dorsomedial Prefrontal Cortex
    Continuous theta-burst stimulation (cTBS), a form of repetitive transcranial magnetic stimulation (rTMS), affects brain areas stimulated directly underneath the scalp and brain areas that are functionally connected. cTBS will be applied to the dorsomedial prefrontal cortex.
  • Experimental: cTBS to Vertex
    Continuous theta-burst stimulation (cTBS), a form of repetitive transcranial magnetic stimulation (rTMS), affects brain areas stimulated directly underneath the scalp and brain areas that are functionally connected. cTBS will be applied to the vertex.

Primary Outcome Measure

Acute effects of cTBS on cognitive control [ Time Frame: 1 hour after receiving cTBS ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Health Neuroscience CenterColumbiaMissouri65203
Brett Froeliger, PhD
[email protected]

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By research site
Health Neuroscience Center· Columbia, MO

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