Beta-Adrenergic Modulation of Drug Cue Reactivity

Part of paid clinical trials in Tulsa, Oklahoma.

Sponsor
University of Oklahoma
Study ID
NCT05587361
Phase
PHASE4
Status
Recruiting
Apply to this trial

Conditions

  • Cigarette Smoking
  • Nicotine Dependence
  • Tobacco Use Disorder

Eligibility Criteria

Sex
ALL
Age
21 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

  • Propranolol — DRUG
    Propranolol Capsule; 40 mg IR
  • Nicotine Patch — DRUG
    Nicotine Patch; 14 mg
  • Placebo Propranolol — DRUG
    Placebo Capsule, no active ingredients
  • Placebo Patch — DRUG
    Placebo Patch, no active ingredients

Study Details

This study is designed to investigate the effects of a beta-adrenergic antagonist (Propranolol; 40 mg IR) and nicotine patch (14 mg) administered alone and in combination on neurobiological and behavioral responses to smoking cues in ongoing cigarette smokers. This is a basic experimental study in humans and participants will not take these medications for an extended period or make a cessation attempt as part of their involvement in this research project.

Key Dates

Start date
Nov 26, 2024
Status verified
Apr 2026
Primary completion
Mar 31, 2027
Completion
Mar 31, 2027

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: Placebo Patch/Placebo Propranolol
    Placebo Nicotine Patch Placebo Propranolol
  • Experimental: Placebo Patch/Active Propranolol
    Placebo Nicotine Patch Active Propranolol (40 mg, immediate release)
  • Experimental: Active Patch/Placebo Propranolol
    Active Nicotine Patch (14 mg) Placebo Propranolol
  • Experimental: Active Patch/Active Propranolol
    Active Nicotine Patch (14 mg) Active Propranolol (40 mg, immediate release)

Primary Outcome Measure

Cue-Provoked Craving Ratings [ Time Frame: Approximately 4-5 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Hardesty Center for Clinical Research and NeuroscienceTulsaOklahoma74136
Isabel Brush, B.A.
[email protected]
Rebecca Gonzalez, B.A.
[email protected]

Find similar trials in Tulsa, OK

By research site
Hardesty Center for Clinical Research and Neuroscience· Tulsa, OK

Related Studies