Paid Clinical Trials in Massachusetts

Massachusetts has 3,587 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 15, 2026.

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3,584 clinical trials

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Global Open-Label Extension Study of Del-desiran for the Treatment of DM1

for Myotonic Dystrophy Type 1

17 locations incl. Los Angeles

Sponsor: Avidity Biosciences, Inc.

Sex: All·Age: 16+

Code: NCT07008469·Phase 3·Enrolling By Invitation

Phase 2/3 Study of KPL-387 in Recurrent Pericarditis

for Pericarditis

27 locations incl. Gilbert

Sponsor: Kiniksa Pharmaceuticals International, plc

Sex: All·Age: 18 - 80

Code: NCT07010159·Phase 2, Phase 3·Recruiting

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Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

for Atherosclerotic Cardiovascular Disease

139 locations incl. Daphne

Sponsor: Amgen

Sex: All·Age: 45 - 99

Code: NCT07037433·Phase 3·Recruiting

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Safety and Efficacy of VDPHL01 in Females With Androgenetic Alopecia (AGA)

for Androgenetic Alopecia (AGA)

71 locations incl. Birmingham

Sponsor: Veradermics, Inc.

Sex: Female·Age: 18 - 65

Code: NCT07146022·Phase 3·Recruiting

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Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

for Breast Cancer

22 locations incl. Duarte

Sponsor: Celcuity Inc

Sex: All·Age: 18+

Code: NCT06757634·Phase 3·Recruiting

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A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression

for Depression

1 location in Chelsea

Sponsor: Juliana Zambrano, MD, MPH

Sex: All·Age: 18 - 64

Code: NCT06597695·Phase 1, Phase 2·Recruiting

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Exercise and Nutrition for Older Cancer Survivors and Their Support Person: The Vitality Study

for Cancer Survivorship

2 locations incl. Miami

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06623097·Recruiting

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Evaluating Q-Collar Effects on Brain Blood Flow Control During Exercise

for Healthy

1 location in Cambridge

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 30·Accepts healthy volunteers

Code: NCT06826781·Recruiting

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Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

for Relapsing Multiple Sclerosis

Drug: Remibrutinib

38 locations incl. Scottsdale

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 40 - 70

Code: NCT06846281·Phase 3·Recruiting

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Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

for Pulmonary Hypertension

25 locations incl. Birmingham

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT06911632·Recruiting

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A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)

for Multiple Myeloma

10 locations incl. Los Angeles

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06953960·Phase 1, Phase 2·Recruiting

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Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application

for Epilepsy

2 locations incl. Worcester

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18+

Code: NCT06425029·Recruiting

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Study of Lenacapavir as a Once-Yearly Injection for HIV Pre-exposure Prophylaxis (PrEP)

for HIV Pre-exposure Prophylaxis

31 locations incl. Birmingham

Sponsor: Gilead Sciences

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07047716·Phase 3·Recruiting

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EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

for Diabetes Mellitus, Type 2

Drug: Empagliflozin

216 locations incl. Anniston

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07064473·Phase 3·Recruiting

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Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

for Neovascular Age-Related Macular Degeneration (nAMD)

54 locations incl. Scottsdale

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 50+

Code: NCT07064759·Phase 3·Recruiting

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A Long-Term Follow-Up Observational Study to Evaluate Safety in Subjects Who Have Received a Gene-Modified Regulatory T Cell (Treg) Therapeutic

for Rheumatoid Arthritis (RA)

10 locations incl. San Francisco

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 71

Code: NCT07123038·Recruiting

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HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease

for Cirrhosis

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05205954·Recruiting

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Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV

for Hiv

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06001814·Recruiting

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A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer

for Ovarian Cancer

14 locations incl. Augusta

Sponsor: Compugen Ltd

Sex: Female·Age: 18+

Code: NCT06888921·Phase 1, Phase 2·Recruiting

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Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

for Pancreatic Neuroendocrine Tumor (pNET)

39 locations incl. Birmingham

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT06943755·Phase 2, Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

for Alzheimer's Disease

Drug: KarXT

30 locations incl. Fullerton

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 60 - 85

Code: NCT06976203·Phase 3·Recruiting

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Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND)

for Major Depressive Disorder

19 locations incl. Phoenix

Sponsor: Cybin IRL Limited

Sex: All·Age: 18 - 85

Code: NCT06605105·Phase 3·Enrolling By Invitation

Evaluation of Two Dose Levels of Quizartinib as Maintenance in FLT3-ITD (+) Acute Myeloid Leukemia Patients in Complete Remission

for Acute Myeloid Leukemia

9 locations incl. Baltimore

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06824168·Phase 2·Recruiting

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Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis

for Familial Adenomatous Polyposis (FAP)

18 locations incl. Arcadia

Sponsor: Rapamycin Holdings Inc.

Sex: All·Age: 18+

Code: NCT06950385·Phase 3·Recruiting

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Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

for Non-small Cell Lung Cancer

22 locations incl. Glendale

Sponsor: Nuvalent Inc.

Sex: All·Age: 18+

Code: NCT06765109·Phase 3·Recruiting

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Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy

for Recurrent Non-Muscle Invasive Bladder Carcinoma

56 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07000084·Phase 3·Recruiting

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A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases

for Systemic Lupus Erythematosus

Drug: Inebilizumab

17 locations incl. Scottsdale

Sponsor: Amgen

Sex: All·Age: 18 - 75

Code: NCT06570798·Phase 2·Recruiting

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The Glaucoma and Retinopathy Screening Study

for Glaucoma

5 locations incl. Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 40+

Code: NCT06882356·Recruiting

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A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias

for High-risk Myelodysplastic Syndrome

11 locations incl. Duarte

Sponsor: Crossbow Therapeutics, Inc.

Sex: All·Age: 12+

Code: NCT06994676·Phase 1·Recruiting

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A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLE

for Macular Edema Secondary to Inflammation

55 locations incl. Phoenix

Sponsor: Kodiak Sciences Inc

Sex: All·Age: 18+

Code: NCT06996080·Phase 3·Recruiting

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A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-2)

for Alzheimer Disease

Drug: KarXT

39 locations incl. Chandler

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 55 - 90

Code: NCT07011745·Phase 3·Recruiting

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A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

for Early Alzheimer's Disease

36 locations incl. Irvine

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 50 - 85

Code: NCT07033494·Phase 2·Recruiting

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Evaluating the Efficacy and Safety of Mirikizumab in Adults Over 60 With Moderate to Severe Crohn's Disease and Ulcerative Colitis

for Crohn Disease (CD)

1 location in Lawrence

Sponsor: Rubix LS

Sex: All·Age: 60 - 99

Code: NCT07059130·Phase 4·Not Yet Recruiting

Early Vedolizumab as First-Line for Immune-Related Colitis Therapy Trial

for Immune Checkpoint Inhibitor-Related Colitis

2 locations incl. Boston

Sponsor: Shilpa Grover, MD, MPH

Sex: All·Age: 18+

Code: NCT06841705·Phase 2·Recruiting

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Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3

for COPD

18 locations incl. Birmingham

Sponsor: Apreo Health, Inc.

Sex: All·Age: 40 - 84

Code: NCT06891755·Recruiting

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A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)

for Chronic Hepatitis B Infection

18 locations incl. Chandler

Sponsor: Aligos Therapeutics

Sex: All·Age: 18 - 65

Code: NCT06963710·Phase 2·Recruiting

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Ivonescimab for the Treatment of Thymic Cancer

for Thymus Carcinoma

Drug: Ivonescimab

5 locations incl. Davis

Sponsor: Jonsson Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06980077·Phase 2·Recruiting

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A Study Evaluating BFB759 in Moderate to Severe Atopic Dermatitis

for Atopic Dermatitis (AD)

48 locations incl. Phoenix

Sponsor: Bluefin Biomedicine, Inc.

Sex: All·Age: 18 - 75

Code: NCT07105488·Phase 2·Recruiting

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Quality of Life in Patients With Postoperative Atrial Fibrillation After Cardiac Surgery

for Postoperative Atrial Fibrillation

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 100

Code: NCT07173998·Recruiting

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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

for Alzheimer's Disease

Drug: KarXT

28 locations incl. Long Beach

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 60 - 85

Code: NCT06976216·Phase 3·Recruiting

Apply to this trial