Paid Clinical Trials in Massachusetts

Massachusetts has 3,584 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 15, 2026.

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3,584 clinical trials

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Real-world Experience Using Nemolizumab in the Treatment of Moderate-to-Severe Atopic Dermatitis in Adolescents & Adults

for Atopic Dermatitis

Drug: Nemolizumab

59 locations incl. Birmingham

Sponsor: Galderma R&D

Sex: All·Age: 12+

Code: NCT06988605·Recruiting

Apply to this trial

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

for COVID-19 Infection

60 locations incl. Canoga Park

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07013474·Phase 3·Recruiting

Apply to this trial

A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)

for Lupus Erythematosus, Systemic

Drug: BMS-986353

40 locations incl. Scottsdale

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 16+

Code: NCT07015983·Phase 2·Recruiting

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Percutaneous Closure Versus Figure-of-eight Suture for Hemostasis in Leadless Pacemaker Implantation.

for Vascular Closure

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT06837870·Enrolling By Invitation

A Study to Evaluate Efficacy of Remibrutinib Compared to Dupilumab at Early Timepoints in Adults With Chronic Spontaneous Urticaria Inadequately Controlled by Second Generation H1-antihistamines

for Chronic Spontaneous Urticaria (CSU)

Drug: Remibrutinib

128 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06868212·Phase 3·Recruiting

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Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

for Optic Neuritis

31 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07100990·Phase 3·Recruiting

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NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia

for Schizophrenia

Drug: NBI-1117568

49 locations incl. Bryant

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18 - 65

Code: NCT07114874·Phase 3·Recruiting

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Investigating the Effects of Cannabidiol on Social Anxiety Disorder

for Phobia, Social

1 location in Cambridge

Sponsor: Massachusetts Institute of Technology

Sex: All·Age: 18 - 55

Code: NCT05649059·Phase 4·Recruiting

Apply to this trial

Simulation Trial of Telemedical Support for Paramedics

for Emergencies

4 locations incl. Aurora

Sponsor: Boston Medical Center

Sex: All·Age: 21+

Code: NCT06441760·Recruiting

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Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV

for HIV-1-infection

2 locations incl. Aurora

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 80

Code: NCT06554717·Phase 2·Recruiting

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A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)

for Alzheimer Disease

Drug: KarXT

40 locations incl. Scottsdale

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 55 - 90

Code: NCT07011732·Phase 3·Recruiting

Apply to this trial

ELEVATE-HFpEF Clinical Study

for Heart Failure With Preserved Ejection Fraction (HFpEF)

25 locations incl. Phoenix

Sponsor: Medtronic Cardiac Rhythm and Heart Failure

Sex: All·Age: 40+

Code: NCT06678841·Recruiting

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Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

for Migraine

35 locations incl. Flagstaff

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 70

Code: NCT06972056·Phase 4·Recruiting

Apply to this trial

H. Pylori Eradication With Argon Plasma During Endoscopy

for Helicobacter Pylori Infection

1 location in Boston

Sponsor: Christopher C. Thompson, MD, MSc

Sex: All·Age: 18+

Code: NCT06529159·Recruiting

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A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

for Major Depressive Disorder

35 locations incl. Dothan

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18 - 74

Code: NCT07076407·Phase 3·Recruiting

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A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participants With Ulcerative Colitis

for Ulcerative Colitis

21 locations incl. Escondido

Sponsor: Sanofi

Sex: All·Age: 18 - 75

Code: NCT06975722·Phase 2·Recruiting

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An Open-label Study of JSB462 (Luxdegalutamide) in Combination With Abiraterone in Adult Male Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

for Metastatic Hormone-sensitive Prostate Cancer

Drug: JSB462

21 locations incl. La Jolla

Sponsor: Novartis Pharmaceuticals

Sex: Male·Age: 18+

Code: NCT06991556·Phase 2·Recruiting

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Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates

for Preterm Less Than 32wks With IVH, WMI/PVL

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 31 Weeks - 42 Weeks

Code: NCT07275021·Recruiting

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Improving Alcohol and Substance Use Care Access, Outcome, Equity During the Reproductive Years

for Alcohol-Related Disorders

4 locations incl. Boston

Sponsor: Emory University

Sex: All·Age: 18+

Code: NCT05910580·Recruiting

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Radiation Free Study

for Aortic Aneurysm

4 locations incl. Birmingham

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT06549348·Recruiting

Apply to this trial

Omalizumab Weight-Based Dosing Efficacy Trial

for Allergies

Drug: Omalizumab

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 1 - 55

Code: NCT06943534·Phase 2·Recruiting

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TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

for Transthyretin Amyloidosis With Cardiomyopathy

Drug: Nucresiran

39 locations incl. La Jolla

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: 18 - 85

Code: NCT07052903·Phase 3·Recruiting

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Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

for Alzheimers Disease

68 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 50 - 90

Code: NCT07177352·Phase 3·Recruiting

Apply to this trial

Early Detection of Gestational Diabetes Mellitus in Pregnancy

for Gestational Diabetes Mellitus in Pregnancy

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 18+

Code: NCT05388643·Recruiting

Apply to this trial

Making Connections Thru Music

for Dementia

1 location in Winchester

Sponsor: Hopeful Aging

Sex: All·Age: 18 - 103·Accepts healthy volunteers

Code: NCT06079216·Not Yet Recruiting

Researching Heat and Yoga for Mood Enhancement

for Depression

2 locations incl. Cambridge

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT06094088·Recruiting

Apply to this trial

RCT of Home-based vs Formal Physical Therapy for Treatment of New Onset Non-insertional Achilles Tendinopathy

for Achilles Tendinopathy

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06374654·Enrolling By Invitation

Personalized Exercise Treatments for Older Veterans With Motoric Cognitive Risk Syndrome

for Motoric Cognitive Risk Syndrome

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 65+

Code: NCT06451874·Recruiting

Apply to this trial

Group Medical Visits and Chiropractic Care for Older Adults With Chronic Spine Pain

for Chronic Pain

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 65+

Code: NCT06632535·Recruiting

Apply to this trial

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

for Prostate Cancer

25 locations incl. Palo Alto

Sponsor: Novartis Pharmaceuticals

Sex: Male·Age: 18 - 100

Code: NCT06855277·Phase 3·Recruiting

Apply to this trial

Glucose Empowerment Through Monitoring and Social Support in Pregnancy

for Pregnancy, Complications

1 location in Boston

Sponsor: Tufts Medical Center

Sex: Female·Age: 18 - 45

Code: NCT07009704·Recruiting

Apply to this trial

PATCHVALVE: Endobronchial Valves Plus Blood Patch for Persistent Air Leaks

for Persistent Air Leaks

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT07184528·Recruiting

Apply to this trial

Efficacy and Safety of MSC-NTF (NurOwn) in Participants With Early Symptomatic ALS and Moderate Disease Presentation in ALS (ENDURANCE STUDY)

for Amyotrophic Lateral Sclerosis (ALS)

15 locations incl. Phoenix

Sponsor: Brainstorm-Cell Therapeutics

Sex: All·Age: 18 - 75

Code: NCT06973629·Phase 3·Not Yet Recruiting

PUL-042 Treatment in Patients With Parainfluenza Virus (PIV), Human Metapneumovirus (hMPV) or Respiratory Syncytial Virus (RSV)

for Hematologic Malignancies

11 locations incl. Duarte

Sponsor: Pulmotect, Inc.

Sex: All·Age: 18+

Code: NCT06665100·Phase 2·Recruiting

Apply to this trial

E-Mindfulness Approaches for Living After Breast Cancer

for Breast Cancer

332 locations incl. Phoenix

Sponsor: NRG Oncology

Sex: All·Age: 18 - 50

Code: NCT06748222·Phase 3·Recruiting

Apply to this trial

The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

for Ischemic Heart Disease (IHD)

12 locations incl. San Francisco

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 35 - 85

Code: NCT06854458·Recruiting

Apply to this trial

Home-Based tDCS Treatment Of Major Depressive Disorder

for Major Depressive Disorder (MDD)

1 location in Boston

Sponsor: Sooma Medical Inc

Sex: All·Age: 22 - 70

Code: NCT06976697·Recruiting

Apply to this trial

Efficacy and Safety of TYRA-300 in Participants With FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer

for Low-grade NMIBC

28 locations incl. Homewood

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT06995677·Phase 2·Recruiting

Apply to this trial

Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study

for Moderate Aortic Valve Stenosis

Drug: Ataciguat

66 locations incl. Birmingham

Sponsor: Kardigan, Inc.

Sex: All·Age: 50+

Code: NCT07001800·Phase 2, Phase 3·Recruiting

Apply to this trial

A Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Moderate to Severe Hidradenitis Suppurativa

for Hidradenitis Suppurativa

49 locations incl. Birmingham

Sponsor: MoonLake Immunotherapeutics AG

Sex: All·Age: 12+

Code: NCT07007637·Phase 3·Enrolling By Invitation