Personalized Exercise Treatments for Older Veterans With Motoric Cognitive Risk Syndrome

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
VA Office of Research and Development
Study ID
NCT06451874
Status
Recruiting
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Conditions

  • Motoric Cognitive Risk Syndrome

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Functional Power Training (FPT) — BEHAVIORAL
    Participants will receive twice weekly FPT, a progressive functional-based exercises that target optimizing leg force production and leg velocity.
  • Music-Based Digital Therapy (MBDT) — BEHAVIORAL
    Participants will receive twice weekly MBDT, a technology-driven gait training that is grounded in evidence-based rehabilitation treatment, rhythmic auditory stimulation.
  • FPT + MBDT — BEHAVIORAL
    For non-responders who were randomized to augment treatment, they will receive combined FPT and MBDT treatment.

Study Details

This study will begin to evaluate personalized preventative dementia treatments for Veterans at risk for developing dementia. The investigators will target Veterans with Motoric Cognitive Risk syndrome (MCR), which is characterized by slow gait speed and cognitive concerns (e.g., problems with memory or concentrations).

Key Dates

Start date
Jul 1, 2025
Status verified
Jul 2025
Primary completion
May 31, 2029
Completion
Dec 31, 2029

Study Design

Enrollment
54 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
PREVENTION

Arms

  • Experimental: Stage 1 Exercise Treatment
    Participants will first be randomized to 6-week exercise treatment (FPT or MBDT)
  • Experimental: Stage 2: Exercise Treatment
    At 6-week, responsiveness (change in gait speed = 0.05 m/s) will be evaluated. Responders will continue with their assigned treatment and non-responders will be randomized to either continue assigned treatment or combined treatment for an additional 6 weeks.

Primary Outcome Measure

Enrollment/Baseline [ Time Frame: Enrollment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MABostonMassachusetts02130-4817
Elisa Ogawa, PhD MS BS
[email protected]
857-364-4011
Elisa Ogawa, PhD MS BS (PRINCIPAL_INVESTIGATOR)

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By research site
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA· Boston, MA

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