Paid Clinical Trials in Massachusetts

Massachusetts has 3,587 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. The most actively recruiting conditions are Breast Cancer, Prostate Cancer, Heart Failure, Ovarian Cancer — browse the full list or use the filters to match your diagnosis. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .

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3,587 clinical trials

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Metabolism Enhancement by Laser Therapy

for Metabolism Disorder
1 location in Boston
Sponsor: Massachusetts General Hospital
Sex: All·Age: 18 - 60·Accepts healthy volunteers
Code: NCT06899958·Not Yet Recruiting

Spine Registration Using 3D-Scanning

for Spine Surgery
1 location in Boston
Sponsor: Advanced Scanners Inc.
Sex: All·Age: 18 - 80·Accepts healthy volunteers
Code: NCT06267248·Enrolling By Invitation

taVNS Treatment for Fibromyalgia

for Fibromyalgia
1 location in Charlestown
Sponsor: Massachusetts General Hospital
Sex: All·Age: 18 - 65
Code: NCT04777500·Not Yet Recruiting

About research studies in Massachusetts

Massachusetts has approximately 3,587 recruiting research studies across a wide range of therapeutic areas. Massachusetts is a global epicenter of biomedical research, anchored by Harvard-affiliated hospitals (MGH, Brigham and Women's, Dana-Farber), Boston Children's Hospital, and the Kendall Square biotech corridor in Cambridge.

Common conditions studied in Massachusetts

  • Breast Cancer (70 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
  • Prostate Cancer (46 active studies). Prostate cancer studies test next-generation hormone therapies, PARP inhibitors, and radioligand treatments for both localized and advanced disease.
  • Heart Failure (41 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
  • Ovarian Cancer (38 active studies). Ovarian cancer research examines PARP inhibitors, maintenance therapies, and antibody-drug conjugates for recurrent and platinum-resistant disease.
  • Acute Myeloid Leukemia (36 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
  • Advanced Solid Tumor (36 active studies). Recruiting Advanced Solid Tumor studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.

Leading research sponsors in Massachusetts

  • Massachusetts General Hospital
  • Brigham and Women's Hospital
  • Boston Children's Hospital
  • Dana-Farber Cancer Institute
  • Beth Israel Deaconess Medical Center

Local regulations and guidelines

Clinical trials in Massachusetts are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Massachusetts trials follow additional state privacy requirements enforced under 201 CMR 17.00 and oversight from the Massachusetts Department of Public Health.

Compensation & what to expect

How payment typically works
Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
Healthy volunteers
Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Massachusetts. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
What's included beyond payment
Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
Travel and time
Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
Asking about compensation
Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.

How to find a clinical trial in Massachusetts

Hipa.ai aggregates every recruiting study in Massachusetts from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.

Frequently asked questions

How many paid clinical trials are currently recruiting in Massachusetts?

There are approximately 3,587 recruiting clinical trials in Massachusetts listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.

Do clinical trials in Massachusetts pay participants?

Most recruiting trials in Massachusetts compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.

Who can participate in a clinical trial in Massachusetts?

Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.

What conditions are most commonly studied in Massachusetts?

The most common conditions under active study in Massachusetts include Breast Cancer (70), Prostate Cancer (46), Heart Failure (41), Ovarian Cancer (38), among many others. Browse the list above to explore every recruiting trial.

Are there clinical trials for healthy volunteers in Massachusetts?

Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Massachusetts on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.

How do I enroll in a clinical trial in Massachusetts?

Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.

Browse more clinical trials

All cities in Massachusetts

Boston, MA(3,016)Worcester, MA(229)Springfield, MA(97)Burlington, MA(94)Waltham, MA(57)Cambridge, MA(48)Belmont, MA(44)Charlestown, MA(42)Newton, MA(34)Foxborough, MA(32)Milford, MA(29)Watertown, MA(29)Peabody, MA(27)Brighton, MA(26)Methuen, MA(24)Beverly, MA(23)Chestnut Hill, MA(21)South Weymouth, MA(20)New Bedford, MA(19)Gloucester, MA(18)Brookline, MA(14)Winchester, MA(14)Plymouth, MA(13)Stoneham, MA(13)Fall River, MA(12)Lowell, MA(12)Quincy, MA(12)Bedford, MA(11)South Dartmouth, MA(11)Needham, MA(10)Natick, MA(9)Lexington, MA(8)Weymouth, MA(8)Danvers, MA(7)Framingham, MA(7)Amherst, MA(6)Jamaica Plain, MA(6)North Dartmouth, MA(6)Hyannis, MA(5)Malden, MA(5)Roslindale, MA(5)Salem, MA(5)Wellesley, MA(5)Westborough, MA(5)Holyoke, MA(4)Marlborough, MA(4)North Worcester, MA(4)Pittsfield, MA(4)Somerville, MA(4)Ayer, MA(3)Brockton, MA(3)Haverhill, MA(3)Lawrence, MA(3)Newburyport, MA(3)Russells Mills, MA(3)Shrewsbury, MA(3)Woburn, MA(3)Acton, MA(2)Allston, MA(2)Andover, MA(2)Braintree, MA(2)Chelsea, MA(2)Concord, MA(2)Fairhaven, MA(2)Hyde Park, MA(2)Medford, MA(2)Melrose, MA(2)Milton, MA(2)Sommerville, MA(2)Wellesley Hills, MA(2)West Roxbury, MA(2)West Springfield, MA(2)Attleboro, MA(1)Dedham, MA(1)Dorchester, MA(1)Dracut, MA(1)East Boston, MA(1)East Weymouth, MA(1)Greenfield, MA(1)Harvard, MA(1)Holliston, MA(1)Leeds, MA(1)Leominster, MA(1)Lynn, MA(1)Multiple Locations, MA(1)Norfolk, MA(1)North Andover, MA(1)North Chelmsford, MA(1)Northampton, MA(1)Norwood, MA(1)Orange, MA(1)Randolph, MA(1)Reading, MA(1)Roxbury, MA(1)Saugus, MA(1)Taunton, MA(1)Uxbridge, MA(1)West Boylston, MA(1)Westford, MA(1)Weston, MA(1)Worester, MA(1)

Related healthcare resources in Massachusetts

Behavioral health news in MassachusettsLatest Massachusetts clinical trials research report

Trials by condition in Massachusetts

Breast Cancer· 70Prostate Cancer· 46Heart Failure· 41Ovarian Cancer· 38Acute Myeloid Leukemia· 36Multiple Myeloma· 35Obesity· 34