Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Brigham and Women's Hospital
Study ID
NCT07441265
Status
Not Yet Recruiting

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Conditions

  • Circadian Misalignment
  • Sex Differences

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Day shift — BEHAVIORAL
    Research participants will be assigned to day shift condition in which sleep-wake and meal schedules are aligned with the internal circadian system
  • Night shift — BEHAVIORAL
    Research participants will be assigned to simulated night shift condition in which sleep-wake and meal schedules are misaligned with the internal circadian system

Study Details

This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag). Researchers will examine how circadian misalignment affects appetite regulation (hunger/fullness) and glucose metabolism (blood sugar control), and whether these effects differ between females and males. Findings may help inform more personalized shift work schedules and targeted strategies to reduce metabolic health risks and sex-related differences in clinical care.

Key Dates

Start date
Oct 1, 2026
Status verified
Feb 2026
Primary completion
Sep 30, 2030
Completion
Sep 30, 2030

Study Design

Enrollment
36 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Day Shift -> Night Shift
    Day Shift protocol first, then Night Shift protocol
  • Experimental: Night shift -> Day shift
    Night shift protocol first, then Day Shift protocol

Primary Outcome Measure

Difference in circulating leptin levels between Night Shift and Day Shift [ Time Frame: 24 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Brigham and Women's HospitalBostonMassachusetts02115
Vy Nguyen, B.S.
[email protected]
(617)-525-0662

Find similar trials in Boston, MA

By research site
Brigham and Women's Hospital· Boston, MA

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