Paid Clinical Trials in Massachusetts

Massachusetts has 3,587 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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3,587 clinical trials

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SMARCA4/2 Inhibitor for POU2F3-Positive SCLC

for Small Cell Lung Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07551635·Phase 2·Not Yet Recruiting

Development and Testing of Nutritional Algorithms (NACHO)

for Nutrition Poor

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05825469·Not Yet Recruiting

Developing an Intervention to Optimize Virtual Care Adoption for COPD Management

for Chronic Obstructive Pulmonary Disease

2 locations incl. Bedford

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+

Code: NCT05986214·Not Yet Recruiting

Pilot Trial of Xylitol for C. Difficile De-Colonization in Patients With Inflammatory Bowel Disease

for Inflammatory Bowel Disease (IBD)

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06799039·EARLY_Phase 1·Not Yet Recruiting

Study on Outcomes of Proximal Humerus Fractures

for Proximal Humerus Fracture

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 65+

Code: NCT07060664·Not Yet Recruiting

The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study

for Opioid Use Disorder

4 locations incl. Miami

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07216963·Not Yet Recruiting

Double-Blind Trial of Everolimus for Improving Social Abilities in PTEN Germline Mutations

for Cowden's Disease

3 locations incl. Stanford

Sponsor: Boston Children's Hospital

Sex: All·Age: 5 - 45

Code: NCT07218575·Phase 2, Phase 3·Not Yet Recruiting

Pivotal Study of N-acetyl-L-leucine for CACNA1A

for CACNA1A

3 locations incl. Baltimore

Sponsor: IntraBio Inc

Sex: All·Age: 4+

Code: NCT07221292·Phase 3·Not Yet Recruiting

Developing Resiliency and Exercise Using AI-based Messaging

for Diabetes Mellitus Type 2

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: All ages

Code: NCT07225283·Not Yet Recruiting

A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The MIND1 Trial

for Treatment Resistant Depression

3 locations incl. Sarasota

Sponsor: NeuroRx, Inc.

Sex: All·Age: 18 - 80

Code: NCT07227103·Phase 2, Phase 3·Not Yet Recruiting

Sonication-based OCD Neurosurgical Intervention Via Capsulotomy

for Obsessive-Compulsive Disorder

2 locations incl. Palo Alto

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 25 - 64

Code: NCT06131502·Phase 1, Phase 2·Not Yet Recruiting

Safety and Efficacy of Mutation-targeted Precision Genetic Therapy for Ataxia-Telangiectasia (A-T)

for Ataxia Telangiectasia

1 location in Boston

Sponsor: Timothy Yu

Sex: All·Age: 0 - 17

Code: NCT07215416·Phase 1, Phase 2·Recruiting

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Ropeginterferon for High Risk JAK2 Clonal Hematopoiesis

for JAK2 Mutation

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07249840·Phase 1·Not Yet Recruiting

Losartan and Paclitaxel in Platinum Resistant Ovarian Cancer

for Platinum Resistant Ovarian Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT07265739·Phase 2·Not Yet Recruiting

Impact of Chia Seeds on Human Breast Milk Composition

for Obesity and Overweight

2 locations incl. Boston

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 45

Code: NCT07343908·Not Yet Recruiting

A Study to Evaluate Claudin 18.2-Directed ADC LCB02A in Advanced Solid Tumors

for Advanced Solid Tumors

2 locations incl. Boston

Sponsor: LigaChem Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT07460375·Phase 1, Phase 2·Not Yet Recruiting

A Pilot Randomized Controlled Trial of a Mental Fitness Intervention for Anesthesiology Resident Wellbeing and Self-Compassion

for Wellness

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07639827·Not Yet Recruiting

my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young Adults

for Sarcoma

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 15 - 24

Code: NCT07516353·Not Yet Recruiting

Ivonescimab Alone And With Carboplatin/Pemetrexed For NSCLC

for Lung Cancer (NSCLC)

Drug: Ivonescimab

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07405190·Phase 2·Not Yet Recruiting

Xylitol Use for Decolonization of C. Difficile in Patients With IBD

for Inflammatory Bowel Diseases

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05852587·Phase 1·Not Yet Recruiting

Sauna for Long Covid

for Long COVID

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT05931497·Recruiting

Apply to this trial

Lactiplantibacillus Plantarum 299v Probiotic Supplementation in Patients With Diabetic Macular Edema

for Diabetic Macular Edema

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 18+

Code: NCT07383701·Phase 2·Not Yet Recruiting

Task-Shifting Adapted IPT-A for Youth Suicide Prevention

for Suicidal Ideation

1 location in Chestnut Hill

Sponsor: Boston College

Sex: All·Age: 12 - 17

Code: NCT07383831·Not Yet Recruiting

Social Identity Mapping for Adolescent Recovery

for Alcohol Use Disorder (AUD)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 12 - 19

Code: NCT07474207·Not Yet Recruiting

Metformin to Attenuate Progressive Respiratory Decline in Idiopathic Pulmonary Fibrosis

for Idiopathic Pulmonary Fibrosis

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 40+

Code: NCT07520110·Phase 3·Not Yet Recruiting

Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS) for Treatment of Post-Traumatic Stress Disorder (PTSD)

for Posttraumatic Stress Disorder (PTSD)

1 location in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07526285·Not Yet Recruiting

A Wearable Sensor Platform for Remote Monitoring of Individuals on the Frontotemporal Dementia Spectrum

for Frontotemporal Lobar Degeneration (FTLD)

2 locations incl. Lutherville

Sponsor: BioSensics

Sex: All·Age: 40+

Code: NCT07569367·Not Yet Recruiting

Perioperative High-flow Nasal Oxygen in Patients Undergoing Robotic Surgery

for Robotic Surgery

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT07591610·Not Yet Recruiting

Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED Study

for Major Depressive Disorder

3 locations incl. San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07596914·Not Yet Recruiting

Online Intervention for Transgender/Nonbinary Young Adults' Experiences With Alcohol and Romantic Relationships

for Alcohol Use, Unspecified

1 location in Boston

Sponsor: Boston University

Sex: All·Age: 18 - 30

Code: NCT06392542·Not Yet Recruiting

Improving the Quality of Care for Asthma Patients at Risk of Exacerbations

for Asthma

6 locations incl. New Haven

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 75

Code: NCT06596512·Not Yet Recruiting

Behavior Analytic Support of Needle-related Hospital Visits for Autistic Patients

for Autism Spectrum Disorder

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 3+

Code: NCT06712784·Recruiting

Apply to this trial

Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock

for Septic Shock

2 locations incl. Boston

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06746753·Phase 4·Not Yet Recruiting

Glaucoma Drop Aids Part 2

for Glaucoma

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT06806332·Not Yet Recruiting

Implementing Depression and Adherence Treatment

for Depression

2 locations incl. Miami

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT07032363·Recruiting

Apply to this trial

Cardiac Anodal Biphasic Pacing

for Cardiac Pacing

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT07173777·Not Yet Recruiting

A First-in-Human Study of KK2223 in Participants With Relapsed or Refractory T Cell Non-Hodgkin Lymphoma

for T-cell NHL (PTCL or CTCL)

Drug: KK2223

7 locations incl. Orange

Sponsor: Kyowa Kirin, Inc.

Sex: All·Age: 18+

Code: NCT07192471·Phase 1·Not Yet Recruiting

NANT 2021-02: Randomized MIBG With Vorinostat/Dinutuximab/Vorinostat + Dinutuximab

for Neuroblastoma

Drug: Vorinostat

13 locations incl. Los Angeles

Sponsor: New Approaches to Neuroblastoma Therapy Consortium

Sex: All·Age: 1 - 30

Code: NCT07261241·Phase 2·Not Yet Recruiting

Randomized Trial of Combination Treatment With Sofwave and Sculptra

for Skin Aging

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT07342452·Phase 4·Not Yet Recruiting

Addition of Venetoclax to Combined Hematopoietic Stem Cell and Kidney Transplantation

for Kidney Failure Chronic

Drug: Venetoclax

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 70

Code: NCT07358195·EARLY_Phase 1·Not Yet Recruiting