Paid Clinical Trials in Massachusetts

Massachusetts has 3,584 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 15, 2026.

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3,584 clinical trials

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Feasibility Study of Prolonged Administration of Naxitamab, Irinotecan, and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma

for Neuroblastoma

Drug: Irinotecan

2 locations incl. Boston

Sponsor: Steven DuBois, MD

Sex: All·Age: 1 - 30

Code: NCT07027748·Phase 1·Recruiting

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A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

for Chronic Obstructive Pulmonary Disease (COPD)

86 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 40+

Code: NCT07082738·Phase 2·Recruiting

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Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

for Ulcerative Colitis

Drug: Tirzepatide

37 locations incl. Dothan

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 70

Code: NCT06937086·Phase 3·Recruiting

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Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

for Crohn's Disease

Drug: Tirzepatide

35 locations incl. Dothan

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 70

Code: NCT06937099·Phase 3·Recruiting

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Data Gathering for A10900

for Retinal Disease

4 locations incl. Anaheim

Sponsor: Optos, PLC

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT07149740·Recruiting

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Sleep Treatment Education Program for Cancer Survivors: STEP-Together

for Insomnia

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT06736548·Recruiting

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REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults

for Venous Thromboembolism (VTE)

19 locations incl. Sheffield

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07015905·Phase 3·Recruiting

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Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

for Obesity

2 locations incl. Boston

Sponsor: Pichamol Jirapinyo, MD, MPH

Sex: All·Age: 18+

Code: NCT06138821·Recruiting

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Safety Study of Viaskin® Peanut Patch in Peanut-Allergic Children 1 Through 3 Years of Age (COMFORT Toddlers)

for Allergy

56 locations incl. Birmingham

Sponsor: DBV Technologies

Sex: All·Age: 1 - 3

Code: NCT07003919·Phase 3·Recruiting

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A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

for Pancreatic Ductal Adenocarcinoma

13 locations incl. Los Angeles

Sponsor: Verastem, Inc.

Sex: All·Age: 18+

Code: NCT07020221·Phase 1, Phase 2·Recruiting

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Smartphone Services for Stimulant Use Disorder

for Stimulant Use Disorder

1 location in Boston

Sponsor: DynamiCare Health

Sex: All·Age: 18+

Code: NCT07092059·Recruiting

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Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

149 locations incl. Gilbert

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06532279·Phase 2·Recruiting

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Infectious Disease (ID) Testing OUtreach in Carceral Hubs

for HIV Infections

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT06679751·Recruiting

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Cocoa Extract for Migraine Trial

for Migraine

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06808230·Recruiting

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Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)

for Hidradenitis Suppurativa

Drug: Ruxolitinib

59 locations incl. Phoenix

Sponsor: Incyte Corporation

Sex: All·Age: 12+

Code: NCT06959225·Phase 3·Recruiting

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab

for Acute Respiratory Distress Syndrome (ARDS)

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701682·Phase 2·Recruiting

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Safety and Efficacy of Endovascular Treatment of Intracranial Aneurysms With Surpass Elite With GUARDian Flow Diverter (GUARD)

for Aneurysm

10 locations incl. Tucson

Sponsor: Stryker Neurovascular

Sex: All·Age: 18 - 80

Code: NCT06872684·Recruiting

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A Study Comparing KB803 and Matched Placebo in Patients With Dystrophic Epidermolysis Bullosa

for Dystrophic Epidermolysis Bullosa

5 locations incl. Rancho Santa Margarita

Sponsor: Krystal Biotech, Inc.

Sex: All·Age: 6 Months+

Code: NCT07016750·Phase 3·Recruiting

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Long-term Characterization of GORE® TAG® Conformable Thoracic Stent Graft With ACTIVE CONTROL System Performance

for Vascular Disease

24 locations incl. Tucson

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06658730·Recruiting

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Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic Cancer

for Locally Advanced Pancreatic Adenocarcinoma

7 locations incl. Scottsdale

Sponsor: EXACT Therapeutics AS

Sex: All·Age: 18+

Code: NCT06850623·Phase 2·Recruiting

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A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

for Major Depressive Disorder (MDD)

28 locations incl. Chino

Sponsor: Seaport Therapeutics

Sex: All·Age: 18 - 65

Code: NCT07065240·Phase 2·Recruiting

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ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™

for Aortic Regurgitation

27 locations incl. Burlingame

Sponsor: JenaValve Technology, Inc.

Sex: All·Age: All ages

Code: NCT06608823·Recruiting

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Behavioral Intervention for Youth to Promote Vaping Cessation

for Vaping

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14 - 18

Code: NCT06765291·Recruiting

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Evaluating Informatics-assisted Immune-related Adverse Event Detection to Improve Registration Onto a Biorepository

for Malignancy

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: All ages

Code: NCT06789601·Phase 1, Phase 2·Recruiting

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Toripalimab With Chemotherapy for Sinus Cancer

for Sinonasal Cancer

2 locations incl. Boston

Sponsor: Glenn J. Hanna

Sex: All·Age: 18+

Code: NCT06940180·Phase 2·Recruiting

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A Study to Investigate the Efficacy and Safety of Bemdaneprocel in Adults Who Have Parkinson's Disease

for Parkinsons Disease (PD)

31 locations incl. Sun City

Sponsor: BlueRock Therapeutics

Sex: All·Age: 45 - 75

Code: NCT06944522·Phase 3·Recruiting

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Balance4Mobility: Effects of Walkasins Use in Individuals With Peripheral Neuropathy and Balance Problems

for Peripheral Neuropathies

6 locations incl. Mesa

Sponsor: RxFunction Inc.

Sex: All·Age: 55+

Code: NCT06959277·Recruiting

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A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis

for Knee Osteoarthritis

3 locations incl. Tucson

Sponsor: 4Moving Biotech

Sex: All·Age: 40 - 80

Code: NCT07225829·Phase 2·Recruiting

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CRC Screening in Unscreened Individuals 45-54

for Colorectal Cancer Screening

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 45 - 54·Accepts healthy volunteers

Code: NCT06757192·Recruiting

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Positive Fit to Colonoscopy: Closing the Gap

for Colorectal Cancer Screening

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT06763432·Recruiting

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Neonatal Platelet Transfusion Threshold Trial

for Thrombocytopenia

20 locations incl. Birmingham

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: 1 Hour - 48 Hours·Accepts healthy volunteers

Code: NCT06676904·Recruiting

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Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial

for Post-ligation Cardiac Syndrome

19 locations incl. Birmingham

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 3 Months

Code: NCT06679855·Phase 3·Recruiting

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A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)

for PIK3CA-Related Overgrowth Spectrum (PROS)

20 locations incl. Phoenix

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 2+

Code: NCT06789913·Phase 2·Recruiting

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Families Left Behind

for Grief

4 locations incl. Birmingham

Sponsor: RAND

Sex: All·Age: 18+

Code: NCT06854757·Recruiting

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Sleep TO Prevent Post-surgical Pain

for Knee Osteoarthristis

2 locations incl. Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 60+

Code: NCT06976138·Recruiting

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Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

for Myelodysplastic Syndrome

138 locations incl. Berkeley

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06577441·Phase 2·Recruiting

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Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment for Relapsed or Refractory Solid Tumors and Fibrolamellar Carcinoma

for Childhood Fibrolamellar Carcinoma

21 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 1 - 39

Code: NCT06620302·Phase 1, Phase 2·Recruiting

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Cervical Preparation for Same-Day Dilation & Evacuation

for Abortion, Second Trimester

1 location in Boston

Sponsor: Boston Medical Center

Sex: Female·Age: 16+·Accepts healthy volunteers

Code: NCT06799052·Recruiting

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Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS2)

for Hidradenitis Suppurativa

Drug: Ruxolitinib

67 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 12+

Code: NCT06958211·Phase 3·Recruiting

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Head-to-Head Evaluation of the Cancer Ontology Supervised Multimodal Orchestration (COSMO) AI System Versus Pathologist-Only Review

for Brain Cancer

1 location in Boston

Sponsor: Harvard Medical School (HMS and HSDM)

Sex: All·Age: All ages

Code: NCT07307157·Enrolling By Invitation