A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
AstraZeneca
Study ID
NCT07082738
Phase
PHASE2
Status
Recruiting
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Conditions

  • Chronic Obstructive Pulmonary Disease (COPD)

Eligibility Criteria

Sex
ALL
Age
40 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • AZD6793 — DRUG
    Oral dosage
  • Placebo — OTHER
    Oral dosage

Study Details

This Phase IIb dose-ranging study will evaluate the efficacy and safety of 2 different doses of AZD6793 compared with placebo tablets in participants with moderate to very severe chronic obstructive pulmonary disease.

Key Dates

Start date
Jun 27, 2025
Status verified
Jun 2026
Primary completion
Nov 5, 2027
Completion
Nov 5, 2027

Study Design

Enrollment
987 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Dose 1 of AZD6793
    Approximately 290 participants will be randomized to receive Dose 1 of AZD6793
  • Experimental: Dose 2 of AZD6793
    Approximately 290 participants will be randomized to receive Dose 2 of AZD6793
  • Placebo Comparator: Matching Placebo
    Approximately 290 participants will be randomized to receive Matching Placebo

Primary Outcome Measure

Annualised rate of moderate or severe COPD exacerbations [ Time Frame: From baseline up to 24 Weeks ]

Central Contacts

Locations (86)

FacilityCityStateZIPSite coordinators
Research SiteBirminghamAlabama35205-
Research SiteGlendaleArizona85306-
Research SitePhoenixArizona85027-
Research SitePhoenixArizona85044-
Research SitePhoenixArizona85051-
Research SiteCanoga ParkCalifornia91303-
Research SiteLa MesaCalifornia91942-
Research SiteLos AngelesCalifornia90017-
Research SiteNewport BeachCalifornia92663-
Research SiteNorcoCalifornia92860-
Research SiteTustinCalifornia92780-
Research SiteLakewoodColorado80228-
Research SiteBrandonFlorida33511-
Research SiteCape CoralFlorida33990-
Research SiteClearwaterFlorida33756-
Research SiteClearwaterFlorida33765-
Research SiteJacksonvilleFlorida32216-
Research SiteLake CityFlorida32055-
Research SiteMiamiFlorida33125-
Research SiteMiamiFlorida33155-
Research SiteMiamiFlorida33173-
Research SiteMiamiFlorida33175-
Research SiteMiamiFlorida33182-
Research SiteMiami LakesFlorida33014-
Research SiteNaplesFlorida34102-
Research SiteOcalaFlorida34471-
Research SiteOrmond BeachFlorida32174-
Research SitePlantationFlorida33324-
Research SiteSarasotaFlorida34239-
Research SiteTamaracFlorida33321-
Research SiteTampaFlorida33606-
Research SiteTampaFlorida33607-
Research SiteWinter ParkFlorida32789-
Research SiteSuwaneeGeorgia30024-
Research SiteWest Des MoinesIowa50266-
Research SiteLexingtonKentucky40503-
Research SiteZacharyLouisiana70791-
Research SiteBaltimoreMaryland21201-
Research SiteBaltimoreMaryland21224-
Research SiteBurlingtonMassachusetts01805-
Research SiteFarmington HillsMichigan48336-
Research SiteGarden CityMichigan48135-
Research SiteGrand RapidsMichigan49546-
Research SiteChesterfieldMissouri63005-
Research SiteHannibalMissouri63401-
Research SiteSt LouisMissouri63110-
Research SiteSt LouisMissouri63141-
Research SiteKalispellMontana59901-
Research SiteMount KiscoNew York10549-
Research SiteNew BernNorth Carolina28562-
Research SiteClevelandOhio44106-
Research SiteMarionOhio43302-
Research SiteOklahoma CityOklahoma73104-
Research SiteTulsaOklahoma74133-
Research SiteMedfordOregon97504-
Research SitePortlandOregon97202-
Research SiteCamp HillPennsylvania17011-
Research SiteDuBoisPennsylvania15801-
Research SitePhiladelphiaPennsylvania19114-
Research SitePhiladelphiaPennsylvania19140-
Research SitePittsburghPennsylvania15213-
Research SiteScottdalePennsylvania15683-
Research SiteSmithfieldPennsylvania15478-
Research SiteLancasterSouth Carolina29720-
Research SiteSpartanburgSouth Carolina29303-
Research SiteRapid CitySouth Dakota57702-
Research SiteChattanoogaTennessee37421-
Research SiteFranklinTennessee37067-
Research SiteJohnson CityTennessee37604-
Research SiteBoerneTexas78006-
Research SiteDallasTexas75254-
Research SiteDenisonTexas75020-
Research SiteEl PasoTexas79902-
Research SiteHoustonTexas77002-
Research SiteHoustonTexas77008-
Research SiteHoustonTexas77030-
Research SiteKingwoodTexas77339-
Research SiteLewisvilleTexas75067-
Research SiteMansfieldTexas76063-
Research SiteMcKinneyTexas75069-
Research SitePearlandTexas77584-
Research SiteColchesterVermont05446-
Research SiteNorfolkVirginia23504-
Research SiteWilliamsburgVirginia23188-
Research SiteMorgantownWest Virginia26505-
Research SiteMadisonWisconsin53715-

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