Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Incyte Corporation
Study ID
NCT06959225
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
12 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Ruxolitinib Cream — DRUG
    Ruxolitinib cream applied topically to the affected area as a thin film twice daily.
  • Vehicle Cream — DRUG
    Matching vehicle cream applied topically to the affected area as a thin film twice daily.

Study Details

The purpose of this study is to evaluate the efficacy and safety of ruxolitinib cream in participants with hidradenitis suppurativa.

Key Dates

Start date
Jun 23, 2025
Status verified
Apr 2026
Primary completion
Oct 9, 2026
Completion
Jul 11, 2027

Study Design

Enrollment
550 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Ruxolitinib 1.5 % Cream
    Participants received ruxolitinib 1.5% cream, applied topically to the affected area as defined in the protocol.
  • Placebo Comparator: Vehicle Cream
    Participants received vehicle cream, applied topically to the affected area as defined by the protocol.

Primary Outcome Measure

Proportion of participants who achieve Hidradenitis Suppurativa (HS) Clinical Response 75 (HiSCR75) from baseline [ Time Frame: Week 16 ]

Central Contacts

Locations (59)

FacilityCityStateZIPSite coordinators
Investigative Site US020PhoenixArizona85008-
Investigative Site US033ScottsdaleArizona85259-
Investigative Site US054TempeArizona85282-
Investigative Site US002FayettevilleArkansas72703-
Investigative Site US055BreaCalifornia92821-
Investigative Site US004Laguna NiguelCalifornia92677-
Investigative Site US007Los AngelesCalifornia90033-
Investigative Site US013San DiegoCalifornia92103-
Investigative Site US038San DiegoCalifornia92121-
Investigative Site US060San DiegoCalifornia92120-
Investigative Site US059AuroraColorado80045-
Investigative Site US045Boynton BeachFlorida33437-
Investigative Site US028Fort MyersFlorida33912-
Investigative Site US016MiamiFlorida33142-
Investigative Site US027SanfordFlorida32771-
Investigative Site US057SweetwaterFlorida33172-
Investigative Site US029TampaFlorida33609-
Investigative Site US053AtlantaGeorgia30331-
Investigative Site US061AtlantaGeorgia30322-
Investigative Site US019MariettaGeorgia30060-
Investigative Site US026ChicagoIllinois60657-
Investigative Site US049ClarksvilleIndiana47129-
Investigative Site US052West LafayetteIndiana47906-
Investigative Site US001Bowling GreenKentucky42104-
Investigative Site US022LouisvilleKentucky40241-
Investigative Site US050Baton RougeLouisiana70809-
Investigative Site US046Glenn DaleMaryland20769-
Investigative Site US003BostonMassachusetts02115-
Investigative Site US030BostonMassachusetts02215-
Investigative Site US010QuincyMassachusetts02169-
Investigative Site US051NoviMichigan48377-
Investigative Site US006MinneapolisMinnesota55455-
Investigative Site US021New BrightonMinnesota55112-
Investigative Site US036Saint JosephMissouri64506-
Investigative Site US034New CityNew York10956-
Investigative Site US017New YorkNew York10023-
Investigative Site US018New YorkNew York10003-
Investigative Site US023RochesterNew York14623-
Investigative Site US014Chapel HillNorth Carolina27516-
Investigative Site US025FargoNorth Dakota58103-
Investigative Site US015BexleyOhio43209-
Investigative Site US044CincinnatiOhio45219-
Investigative Site US008ColumbusOhio43230-
Investigative Site US031MasonOhio45040-
Investigative Site US048Oklahoma CityOklahoma73118-
Investigative Site US043DanvillePennsylvania17822-
Investigative Site US056PhiladelphiaPennsylvania19107-
Investigative Site US024CharlestonSouth Carolina29425-
Investigative Site US041Myrtle BeachSouth Carolina29788-
Investigative Site US047NashvilleTennessee37215-
Investigative Site US062DallasTexas75390-
Investigative Site US035El PasoTexas79902-
Investigative Site US032FriscoTexas75033-
Investigative Site US012PlanoTexas75025-
Investigative Site US011San AntonioTexas78213-
Investigative Site US040LaytonUtah84041-
Investigative Site US037MurrayUtah84107-
Investigative Site US039OgdenUtah84405-
Investigative Site US058SeattleWashington98195-

Find similar trials in Phoenix, AZ

By condition
Hidradenitis suppurativa
By specialty
DermatologyRheumatologyAutoimmune disease
By research site
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