A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

Part of paid clinical trials in Long Beach, California.

Sponsor
Bristol-Myers Squibb
Study ID
NCT06976216
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
60 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • KarXT — DRUG
    Specified dose on specified days
  • KarX-EC — DRUG
    Specified dose on specified days
  • Placebo — OTHER
    Specified dose on specified days

Study Details

The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC for cognitive impairment in Alzheimer's Disease

Key Dates

Start date
Jul 14, 2025
Status verified
May 2026
Primary completion
Sep 11, 2028
Completion
Feb 23, 2029

Study Design

Enrollment
586 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: KarXT + KarX-EC
  • Placebo Comparator: Placebo

Primary Outcome Measure

Change from baseline in Alzheimer's Disease Assessment Scale-Cognitive Subscale 11 (ADAS-Cog11) [ Time Frame: At week 24 ]

Central Contacts

  • BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
    855-907-3286
    [email protected]
  • First line of the email MUST contain NCT # and Site #.

Locations (28)

FacilityCityStateZIPSite coordinators
Healthy Brain ClinicLong BeachCalifornia90804
Dung Trinh, Site 0173
562-606-5999
Anderson Clinical ResearchRedlandsCalifornia92374
Donald Anderson, Site 0008
909-792-9007
Mountain Neurological Research CenterBasaltColorado81621
Alison Allen, Site 0025
970-927-1141
Georgetown University Medical CenterWashington D.C.District of Columbia20007
Raymond Turner, Site 0024
202-687-7337
JEM Research InstituteAtlantisFlorida33462
Linda Pao, Site 0154
561-968-2933
VIN-Julie SchwartzbardAventuraFlorida33180
Julie Schwartzbard, Site 0128
305-799-9459
Merritt Island Medical Research, LLCMerritt IslandFlorida32952
Wasim Niazi, Site 0023
386-785-8009
Renstar Medical ResearchOcalaFlorida34470
Anette Nieves, Site 0055
352-629-5800
Alzheimer's Research and Treatment CenterStuartFlorida34997
Adam Falchook, Site 0263
561-209-2400
Charter Research - Lady LakeThe VillagesFlorida32162
Jeffrey Norton, Site 0184
352-775-1000
Local Institution - 0016ColumbusGeorgia31909-
Center for Advanced Research & EducationGainesvilleGeorgia30501
Chris Recknor, Site 0125
770-630-9615
Re:Cognition Health - ChicagoChicagoIllinois60611
Antonio Iglesias, Site 0109
312-971-3318
Ascension Alexian BrothersElk Grove VillageIllinois60007
Concetta Forchetti, Site 0054
847-593-8553
Boston Center for MemoryNewtonMassachusetts02459
Paul Solomon, Site 0009
413-281-0577
HealthPartners Neuroscience CenterSaint PaulMinnesota55130
Marcel Hungs, Site 0110
111-111-1111
Advanced Memory Research Institute of New JerseyToms RiverNew Jersey08755
Arun Singh, Site 0123
732-341-9500
Local Institution - 0259New YorkNew York10029-
NYU Langone HealthNew YorkNew York10016
Martin Sadowski, Site 0101
212-263-5708
SUNY Upstate Medical UniversitySyracuseNew York13210
Sharon Brangman, Site 0202
315-436-0177
AMC Research, LLCMatthewsNorth Carolina28105
Mohammad Bolouri, Site 0007
7043644000ext225
Ohio State UniversityColumbusOhio43221
Douglas Scharre, Site 0073
NDx Clinical Research Inc.DaytonOhio45459
Joel Vandersluis, Site 0026
937-224-8200
Summit HeadlandsPortlandOregon97210
Scott Losk, Site 0067
503-279-8252
Local Institution - 0004AbingtonPennsylvania19001-
Rhode Island Mood & Memory Research InstituteEast ProvidenceRhode Island02914
john stoukides, Site 0056
401-435-8950
Neurology Clinic, P.C.CordovaTennessee38018
Thomas Arnold, Site 0099
901-866-9252
Gadolin ResearchBeaumontTexas77702
Joseph Oommen, Site 0018
409-331-6040

Find similar trials in Long Beach, CA

By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
Healthy Brain Clinic· Long Beach, CAAnderson Clinical Research· Redlands, CAMountain Neurological Research Center· Basalt, COGeorgetown University Medical Center· Washington D.C., DCJEM Research Institute· Atlantis, FLVIN-Julie Schwartzbard· Aventura, FL

Related Studies