Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease

Part of paid clinical trials in Columbus, Ohio.

Sponsor
Douglas Scharre
Study ID
NCT03019757
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • DaTscan — RADIATION
    A functional imaging of the dopamine transporter using the radioligand \[123I\]FP-CIT
  • F18-AV-45 — RADIATION
    A brain scan to to measure the extent of amyloid deposition
  • FDG-PET — RADIATION
    a brain scan measuring total and regional cerebral glucose metabolism wtih positron emission tomographs with 2-(18F)
  • APOE genotype — GENETIC
    10 ml of whole blood will be drawn and shipped to Athena Diagnostics for genetic testing.
  • Polysomnogram — PROCEDURE
    Overnight sleep study
  • Clinical Assessment — BEHAVIORAL
    Clinical assessments include cognitive, behavioral, and motor evaluations

Study Details

The study is designed to characterize the clinical, neuropsychological, polysomnographic, and neuroimaging findings among subjects with Alzheimer's disease, Lewy Body dementia, and Parkinsons' Disease.

Key Dates

Start date
Aug 30, 2018
Status verified
Mar 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
76 participants (estimated)

Arms

  • Arm: Alzheimer's disease
    Individuals with a clinical diagnosis of Alzheimer's disease will undergo the interventions including DaTscan, F18-AV-45, FDG-PET, APOE genotype, Polysomnogram, and Clinical Assessment.
  • Arm: Lewy Body dementia
    Individuals with a clinical diagnosis of Lewy Body Dementia will undergo the interventions including DaTscan, F18-AV-45, FDG-PET, APOE genotype, Polysomnogram, and Clinical Assessment.
  • Arm: Parkinson's disease
    Individuals with a clinical diagnosis of Parkinson's disease will undergo the interventions including DaTscan, F18-AV-45, FDG-PET, APOE genotype, Polysomnogram, and Clinical Assessment.

Primary Outcome Measure

Mini Mental State Examination (MMSE-1) [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The Ohio State UniversityColumbusOhio43210
Jennifer Icenhour
[email protected]
614-293-6882

Find similar trials in Columbus, OH

By condition
Alzheimer's diseaseParkinson's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
The Ohio State University· Columbus, OH

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