A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

Part of paid clinical trials in Irvine, California.

Sponsor
Merck Sharp & Dohme LLC
Study ID
NCT07033494
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Early Alzheimer's Disease

Eligibility Criteria

Sex
ALL
Age
50 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • MK-2214 — BIOLOGICAL
    IV infusion
  • Placebo — DRUG
    IV infusion

Study Details

Researchers want to know if the study treatment called MK-2214 works to slow certain changes in the brains of people with Alzheimer's disease (AD). AD is a type of dementia that can cause loss of memory, communication (such as speech), and decision-making skills. It can limit a person's ability to do daily tasks. MK-2214 is a study treatment designed to slow down AD. The goals of the study are to learn: * If MK-2214 slows the spread of tau in the brain compared to placebo. Tau is a protein that accumulates in AD \& damages brain cells. A placebo looks like the study treatment but has no study treatment in it. Using a placebo helps researchers better understand the effects of a study treatment. * About the safety of MK-2214 and if people tolerate it

Key Dates

Start date
Jul 16, 2025
Status verified
May 2026
Primary completion
Apr 30, 2029
Completion
Apr 30, 2029

Study Design

Enrollment
340 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: MK-2214
    Participants will receive MK-2214 via intravenous (IV) infusion every 4 weeks (q4w) during the study.
  • Placebo Comparator: Placebo
    Participants will receive a placebo via IV infusion q4w during the study.

Primary Outcome Measure

Change from Baseline in Tau PET Standardized Uptake Value Ratio (SUVr) [ Time Frame: Baseline, up to approximately 23 months ]

Central Contacts

Locations (36)

FacilityCityStateZIPSite coordinators
Irvine Clinical Research ( Site 1041)IrvineCalifornia92614
Study Coordinator
949-753-1663
Healthy Brain Clinic ( Site 1005)Long BeachCalifornia90804
Study Coordinator
562-606-5999
Inglewood Clinical ( Site 1062)Los AngelesCalifornia90056
Study Coordinator
949-265-1612
Anderson Clinical Research ( Site 1024)RedlandsCalifornia92374
Study Coordinator
909-792-9007
UCSF Memory and Aging Center ( Site 1031)San FranciscoCalifornia94158
Study Coordinator
415-353-3585
Syrentis Clinical Research ( Site 1001)Santa AnaCalifornia92705
Study Coordinator
714-542-3008
Yale University, Alzheimer's Disease Research Unit ( Site 1059)New HavenConnecticut06510
Study Coordinator
203-764-8100
JEM Research Institute ( Site 1046)AtlantisFlorida33462
Study Coordinator
561-968-2933
Neuropsychiatric Research Center of Southwest Florida ( Site 1003)Fort MyersFlorida33912
Study Coordinator
239-939-7777
Indago Research & Health Center, Inc ( Site 1044)HialeahFlorida33012
Study Coordinator
305-825-6588
K2 Medical Research ( Site 1047)MaitlandFlorida32750
Study Coordinator
407-500-5252
ClinCloud LLC ( Site 1039)MelbourneFlorida32940
Study Coordinator
407-680-0534
Aqualane Clinical Research ( Site 1035)NaplesFlorida34105
Study Coordinator
239-529-6780
Suncoast Clinical Research ( Site 1007)New Port RicheyFlorida34652
Study Coordinator
727-849-4131
Renstar Medical Research ( Site 1012)OcalaFlorida34471
Study Coordinator
352-629-5800
Charter Research - Orlando ( Site 1051)OrlandoFlorida32803
Study Coordinator
407-337-3000
Axiom Brain Health ( Site 1029)TampaFlorida33609
Study Coordinator
813-353-9613
K2 Medical Research ( Site 1020)TampaFlorida33634
Study Coordinator
813-800-5252
Charter Research - Lady Lake ( Site 1019)The VillagesFlorida32162
Study Coordinator
352-775-1000
Conquest Research LLC ( Site 1053)Winter ParkFlorida32789
Study Coordinator
407-916-0060
CenExel iResearch, LLC ( Site 1015)DecaturGeorgia30030
Study Coordinator
404-537-1281
Alexian Brothers Medical Center-Neurosciences ( Site 1017)Elk Grove VillageIllinois60007
Study Coordinator
847-593-8553
Boston Center for Memory ( Site 1008)NewtonMassachusetts02459
Study Coordinator
617-699-6927
Clinical Research Professionals ( Site 1004)ChesterfieldMissouri63005
Study Coordinator
636-220-1200
The Cognitive and Research Center of New Jersey - Ridgewood ( Site 1064)RidgewoodNew Jersey07450
Study Coordinator
201-850-4622
The Cognitive and Research Center of NJ ( Site 1057)SpringfieldNew Jersey07081
Study Coordinator
973-850-4622
CenExel- AMRI ( Site 1018)Toms RiverNew Jersey08755
Study Coordinator
732-341-9500
Alzheimer Disease Research Center (ADRC) ( Site 1000)AlbanyNew York12208
Study Coordinator
518-426-0575
Mid Hudson Medical Research ( Site 1050)New WindsorNew York12553
Study Coordinator
845-674-9398
Basil Clinical ( Site 1065)QueensNew York11413
Study Coordinator
917-672-3275
AMC Research, LLC ( Site 1006)MatthewsNorth Carolina28105
Study Coordinator
704-364-4000
Insight Clinical Trials ( Site 1011)IndependenceOhio44131
Study Coordinator
216-245-6556
Neuro-Behavioral Clinical Research ( Site 1028)North CantonOhio44720
Study Coordinator
330-493-1118
Flourish Research ( Site 1048)Plymouth MeetingPennsylvania19462
Study Coordinator
610-277-8073
Gadolin Research ( Site 1032)BeaumontTexas77702
Study Coordinator
409-331-6040
Horizon Clinical Research Center - Houston ( Site 1026)CypressTexas77429
Study Coordinator
949-491-0710

Find similar trials in Irvine, CA

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Irvine Clinical Research· Irvine, CAHealthy Brain Clinic· Long Beach, CAInglewood Clinical· Los Angeles, CAAnderson Clinical Research· Redlands, CAUCSF Memory and Aging Center· San Francisco, CASyrentis Clinical Research· Santa Ana, CA

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