Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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The Radiation Oncology-Biology Integration Network (ROBIN) Molecular Characterization Trial (MCT) of Standard Short Course Radiotherapy for Rectal Cancer

for Rectal Cancer

5 locations incl. Chicago

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 90

Code: NCT05943210·Recruiting

Apply to this trial

Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

for Stroke

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06598150·Recruiting

Apply to this trial

MASA Valve Early Feasibility Study

for Tetrology of Fallot

5 locations incl. Peoria

Sponsor: PECA Labs

Sex: All·Age: 0 - 22

Code: NCT05452720·Recruiting

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A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

for Ulcerative Colitis

22 locations incl. Mobile

Sponsor: Takeda

Sex: All·Age: 2+

Code: NCT05442567·Phase 3·Recruiting

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Clinical Trial of Approaches to Prostate Cancer Surgery

for Prostate Cancer

9 locations incl. Duarte

Sponsor: Weill Medical College of Cornell University

Sex: Male·Age: 40 - 80

Code: NCT05155501·Recruiting

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A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

for Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype

8 locations incl. Chicago

Sponsor: Debiopharm International SA

Sex: All·Age: 18+

Code: NCT05765812·Phase 1, Phase 2·Recruiting

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A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

Drug: Nivolumab

390 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 5 - 60

Code: NCT05675410·Phase 3·Recruiting

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CIED Infection Quality Initiative Demonstration Project

for Infections

3 locations incl. Chicago

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT05471973·Recruiting

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LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions

for Angina

10 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 65+

Code: NCT05786417·Phase 4·Recruiting

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A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)

for Focal Onset Seizures

19 locations incl. Little Rock

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05716100·Phase 3·Recruiting

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A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

for Heart Failure

Drug: Ziltivekimab

184 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT05636176·Phase 3·Recruiting

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Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

454 locations incl. Daphne

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05642572·Phase 2·Recruiting

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A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer

for Advanced Prostate Cancer

5 locations incl. Scottsdale

Sponsor: Genentech, Inc.

Sex: Male·Age: 18+

Code: NCT05800665·Phase 1·Recruiting

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Myopia Control: a Comparison Study Between Atropine and MiSight

for Myopia

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 5 - 12

Code: NCT05815784·Phase 2·Recruiting

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Outcome Comparisons of Vibratory Airway Clearance Devices

for Airway Clearance Impairment

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT05873504·Recruiting

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Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait

for Amputation

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 95

Code: NCT06433648·Recruiting

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Comparison of Transforming Powder Dressing to NPIAP Recommended Standard of Care Therapies in Stage 2, 3 and 4 Pressure Injuries

for Pressure Ulcers Stage II

14 locations incl. San Diego

Sponsor: ULURU Inc.

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT05496296·Recruiting

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Empathic Communication Skills (ECS) Training

for Lung Cancer

12 locations incl. Irvine

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05456841·Recruiting

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MRI Risk Maps for Prostate Cancer Diagnosis Using Targeted Biopsy

for Prostate Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: Male·Age: 18+

Code: NCT05710380·Recruiting

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Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial

for Recurrent Endometrial Carcinoma

Drug: Selumetinib

293 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT05554328·Phase 2·Recruiting

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A Study of CTX-712 in Relapsed/Refractory Acute Myeloid Leukemia and Higher Risk Myelodysplastic Syndromes

for Acute Myeloid Leukemia

8 locations incl. Phoenix

Sponsor: Chordia Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05732103·Phase 1, Phase 2·Recruiting

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A Study to Compare the Efficacy, Safety and Tolerability of FF/UMEC/VI With FF/VI in 12-17-year-olds With Asthma

for Asthma

28 locations incl. Birmingham

Sponsor: GlaxoSmithKline

Sex: All·Age: 12 - 17

Code: NCT05757102·Phase 3·Recruiting

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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

for Cystic Fibrosis

59 locations incl. Birmingham

Sponsor: Chris Goss

Sex: All·Age: 6+

Code: NCT05548283·Phase 4·Recruiting

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Multimodal Haptic Feedback for Plantar Sensory Substitution

for Hypoesthesia

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT06232512·Recruiting

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VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

for Solid Tumor

Drug: Atezolizumab

7 locations incl. Chicago

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 6 Months - 30

Code: NCT04796012·Phase 1, Phase 2·Recruiting

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Pounce™ Thrombectomy System Retrospective Registry

for Peripheral Arterial Disease

9 locations incl. Peoria

Sponsor: SurModics, Inc.

Sex: All·Age: 18+

Code: NCT05868161·Recruiting

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Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

for Heart Diseases

42 locations incl. Los Angeles

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18+

Code: NCT04124120·Recruiting

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Nutrition for Precision Health, Powered by the All of Us

for Nutrition

14 locations incl. Birmingham

Sponsor: RTI International

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05701657·Recruiting

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Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

for Neurotrophic Keratopathy

29 locations incl. Laguna Hills

Sponsor: ReGenTree, LLC

Sex: All·Age: 18+

Code: NCT05555589·Phase 3·Recruiting

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Tocilizumab for Acute Chest Syndrome

for Sickle Cell Disease

Drug: Tocilizumab

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 12+

Code: NCT05640271·Phase 2·Recruiting

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Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant

for Pre-Bronchiolitis Obliterans Syndrome

20 locations incl. Phoenix

Sponsor: Renovion, Inc.

Sex: All·Age: 18 - 75

Code: NCT05654922·Phase 3·Recruiting

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

for Advanced Malignant Solid Neoplasm

475 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: All ages

Code: NCT05564377·Phase 2·Recruiting

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Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

for Prediabetic State

40 locations incl. Phoenix

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT02915198·Phase 4·Recruiting

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Study of RiMO-301 and Radiotherapy With PD-1 Inhibitor for the Treatment of Head-Neck Cancer

for Head Neck Cancer

1 location in Chicago

Sponsor: Coordination Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05838729·Phase 1, Phase 2·Recruiting

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Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

for Multiple Sclerosis

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 64

Code: NCT05051618·Recruiting

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Improving the Health and Social Participation of People With Disabilities From Underrepresented Groups Post COVID

for Disabilities Multiple

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT05792852·Recruiting

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The Impact of Skin Tone on Pulse Oximeter Accuracy

for Accuracy of Pulse Oximetry Across Skin Pigmentation Levels

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT07415187·Recruiting

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A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

for Breast Cancer, Early Breast Cancer

Drug: Camizestrant

127 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT05774951·Phase 3·Recruiting

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Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

for Metastatic Melanoma

Drug: Lifileucel

22 locations incl. Birmingham

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT05727904·Phase 3·Recruiting

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Venetoclax Basket Trial for High Risk Hematologic Malignancies

for Myelodysplastic Syndromes, de Novo

Drug: Venetoclax

5 locations incl. San Francisco

Sponsor: Andrew E. Place, MD

Sex: All·Age: 1 - 40

Code: NCT05292664·Phase 1·Recruiting

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