Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

for Psychosis Associated With Alzheimer's Disease

Drug: KarXT

147 locations incl. Homewood

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 55 - 90

Code: NCT05980949·Phase 3·Recruiting

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Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients

for Obesity, Morbid

4 locations incl. Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT05918575·Recruiting

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Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

for Metastatic Malignant Solid Neoplasm

22 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05687110·Phase 1·Recruiting

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Cardiac Power Output in Cardiogenic Shock Patients

for Heart Failure

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05700617·EARLY_Phase 1·Recruiting

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Study of MK-0472 in Participants With Advanced/Metastatic Solid Tumors (MK-0472-001)

for Metastatic Solid Tumors

4 locations incl. Chicago

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT05853367·Phase 1·Recruiting

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A Pilot Clinical Evaluation of Astepro® Nasal Spray for Management of Early SARS-CoV-2 Infection

for COVID-19

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06008860·Phase 4·Recruiting

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Relationship of the Microenvironment and Male Fertility

for Male Infertility

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: Male·Age: 18+

Code: NCT04704141·Not Yet Recruiting

A Study Assessing KB407 for the Treatment of Cystic Fibrosis

for Cystic Fibrosis

6 locations incl. Gainesville

Sponsor: Krystal Biotech, Inc.

Sex: All·Age: 18+

Code: NCT05504837·Phase 1·Recruiting

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Outcomes in Pediatric and Young Adult B-Cell Malignancies After Commercially Available Immunotherapy

for Lymphoid Leukemia

22 locations incl. Tucson

Sponsor: Stanford University

Sex: All·Age: Up to 26

Code: NCT05865301·Recruiting

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ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors

for Non Small Cell Lung Cancer

46 locations incl. Dothan

Sponsor: OncoC4, Inc.

Sex: All·Age: 18+

Code: NCT05671510·Phase 3·Recruiting

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A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

for Chronic Obstructive Pulmonary Disease

68 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 40 - 90

Code: NCT05878769·Phase 3·Recruiting

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Lupus Landmark Study: A Prospective Registry and Biorepository

for Systemic Lupus Erythematosus (SLE)

19 locations incl. Birmingham

Sponsor: Lupus Research Alliance

Sex: All·Age: 18 - 110

Code: NCT05934149·Recruiting

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A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children

for Chronic Pain

7 locations incl. San Francisco

Sponsor: Telethon Kids Institute

Sex: All·Age: Up to 16·Accepts healthy volunteers

Code: NCT06354699·Recruiting

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IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)

for Non Small Cell Lung Cancer

Drug: Durvalumab

6 locations incl. St. Petersburg

Sponsor: Innate Pharma

Sex: All·Age: 18+

Code: NCT05742607·Phase 2·Recruiting

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A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

Drug: Iberdomide

44 locations incl. Aurora

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05827016·Phase 3·Recruiting

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A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

for Hidradenitis Suppurativa

Drug: Upadacitinib

87 locations incl. Birmingham

Sponsor: AbbVie

Sex: All·Age: 12+

Code: NCT05889182·Phase 3·Recruiting

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Surgical Treatments for Postamputation Pain

for Residual Limb Pain

3 locations incl. Chicago

Sponsor: Prometei Pain Rehabilitation Center

Sex: All·Age: 18+

Code: NCT05009394·Recruiting

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Trial to Evaluate the Safety and Effectiveness of Treatment With COMS One Device in Subjects With Diabetic Foot Ulcers

for Diabetic Foot Ulcer

30 locations incl. Mesa

Sponsor: Piomic Medical

Sex: All·Age: 22 - 90

Code: NCT05758545·Recruiting

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Preoperative Weight Loss for Open Abdominal Wall Reconstruction

for Abdominal Wall Hernia

2 locations incl. Chicago

Sponsor: Benjamin T. Miller

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05925959·Recruiting

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Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

for Colorectal Polyp

18 locations incl. Birmingham

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 65 - 82

Code: NCT05612347·Recruiting

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Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

for Anatomic Stage II Breast Cancer AJCC v8

820 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05812807·Phase 3·Recruiting

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Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab

for Relapsing Multiple Sclerosis

36 locations incl. Birmingham

Sponsor: TG Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT05877963·Phase 3·Recruiting

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Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

for Diffuse Large B-Cell Lymphoma

87 locations incl. Tucson

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05633615·Phase 2·Recruiting

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Repurposing Dupilumab for Management of Pruritic Genetic Inflammatory Skin Disorders

for Skin Diseases

Drug: Dupilumab

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 6 Months+

Code: NCT05649098·EARLY_Phase 1·Recruiting

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Alzheimer's Disease Neuroimaging Initiative 4

for Mild Cognitive Impairment

59 locations incl. Birmingham

Sponsor: University of Southern California

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05617014·Enrolling By Invitation

Study of ALTO-300 in MDD

for Major Depressive Disorder

45 locations incl. Phoenix

Sponsor: Alto Neuroscience

Sex: All·Age: 18 - 70

Code: NCT05922878·Phase 2·Recruiting

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Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

for Sickle Cell Disease

9 locations incl. Birmingham

Sponsor: RTI International

Sex: All·Age: 18+

Code: NCT06385886·Recruiting

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Implementing Contingency Management for Stimulant Use in Specialty Addiction Treatment Organizations

for Stimulant Use (Diagnosis)

9 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05702021·Recruiting

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rhPSMA-73 PET-MRI Imaging for the Detection of Prostate Cancer Among Men Who Are Otherwise Candidates for Active Surveillance

for Prostate Adenocarcinoma

1 location in Chicago

Sponsor: Northwestern University

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT05852041·EARLY_Phase 1·Recruiting

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External Sensing and Neuromodulation to Assess Diabetic Pain Outcomes (XANADO)

for Chronic Pain

1 location in Chicago

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT05537662·Recruiting

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SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

for Glioma

40 locations incl. Birmingham

Sponsor: Nuvation Bio Inc.

Sex: All·Age: 18+

Code: NCT05303519·Phase 3·Recruiting

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Effect of Cooling Therapy for Post-Operative Pain in Open Carpal Tunnel Release

for Carpal Tunnel Syndrome

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05783245·Recruiting

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Enhanced Clinical Decisions for Management of Benign Prostatic Hyperplasia Using Patient-Reported Outcomes

for Benign Prostatic Hyperplasia

1 location in Glenview

Sponsor: Northwestern University

Sex: Male·Age: 50+

Code: NCT05898932·Recruiting

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Interactive Computer-adaptive Chronic Kidney Disease Education Program

for Chronic Kidney Diseases

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70

Code: NCT06364358·Recruiting

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Study of Belantamab Mafodotin With Carfilzomib, Pomalidomide, and Dexamethasone in Relapsed Multiple Myeloma

for Multiple Myeloma

Drug: Belantamab mafodotin

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05789303·Phase 2·Recruiting

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Predictors of Behavioral Obesity Treatment Outcomes

for Obesity

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05326477·Recruiting

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Comparison of EVAR and ESAR for Infrarenal Aortic Aneurysms With a Wide Proximal Neck

for Aortic Aneurysm, Abdominal

16 locations incl. Washington

Sponsor: Rijnstate Hospital

Sex: All·Age: 18+

Code: NCT05484115·Recruiting

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Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

for Locally Advanced Solid Tumor

15 locations incl. Palo Alto

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05732831·Phase 1, Phase 2·Recruiting

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Daratumumab for Chemotherapy-Refractory Minimal Residual Disease in T Cell ALL

for T-cell Acute Lymphoblastic Leukemia

Drug: Daratumumab

1 location in Chicago

Sponsor: Eastern Cooperative Oncology Group

Sex: All·Age: 18+

Code: NCT05289687·Phase 2·Recruiting

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LH Canine Therapy Study

for Emotion Regulation

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: All·Age: 8 - 18

Code: NCT05840198·Recruiting

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