IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)

Part of paid clinical trials in St. Petersburg, Florida.

Sponsor
Innate Pharma
Study ID
NCT05742607
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • IPH5201 + durvalumab + standard chemotherapy — DRUG
    Patients will receive Neoadjuvant therapy with IPH5201 and durvalumab in addition to standard chemotherapy. Following surgery, patients will receive adjuvant treatment with IPH5201 and durvalumab.

Study Details

The study is intended to assess the safety and efficacy of neoadjuvant combination of IPH5201 and durvalumab in addition to standard chemotherapy and adjuvant combination of IPH5201 and durvalumab in untreated patients with resectable, early-stage (stage II to IIIA) non-small cell lung cancer (NSCLC).

Key Dates

Start date
Jun 23, 2023
Status verified
May 2025
Primary completion
Jun 30, 2025
Completion
Sep 30, 2026

Study Design

Enrollment
70 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: IPH5201 + durvalumab + standard chemotherapy
    Patients will receive Neoadjuvant therapy with IPH5201 and durvalumab in addition to standard chemotherapy. Following surgery, patients will receive adjuvant treatment with IPH5201 and durvalumab.

Primary Outcome Measure

Pathological Complete Response (pCR) [ Time Frame: 16 weeks after the first dose of study intervention. ]

Central Contacts

Locations (6)

FacilityCityStateZIPSite coordinators
St. Anthony's Hospital - BayCare Health SystemSt. PetersburgFlorida33705
Ahmad Shaker
H. Lee Moffitt Cancer Center & Research InstituteTampaFlorida33612
Alberto Chiappori
University of Chicago Medical CenterChicagoIllinois60637
Everett Vokes
Northwell Health Cancer Institute / Center for Novel Cancer TherapeuticsLake SuccessNew York11042
Nagashree Seetharamu
Millennium Research & Clinical DevelopmentHoustonTexas77090
Anirudha Dasgupta
UW Carbone Cancer Center - Cancer ConnectMadisonWisconsin53792
Vincent Ma
[email protected]
800-622-8922

Find similar trials in St. Petersburg, FL

By condition
Lung cancer
By specialty
OncologyLung oncologyLung disease
By research site
St. Anthony's Hospital - BayCare Health System· St. Petersburg, FLH. Lee Moffitt Cancer Center & Research Institute· Tampa, FLUniversity of Chicago Medical Center· Chicago, ILNorthwell Health Cancer Institute / Center for Novel Cancer Therapeutics· Lake Success, NYMillennium Research & Clinical Development· Houston, TXUW Carbone Cancer Center - Cancer Connect· Madison, WI

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