Lupus Landmark Study: A Prospective Registry and Biorepository

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Lupus Research Alliance
Study ID
NCT05934149
Status
Recruiting
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Conditions

  • Lupus Nephritis
  • Neuropsychiatric Systemic Lupus Erythematosus
  • Systemic Lupus Erythematosus (SLE)

Eligibility Criteria

Sex
ALL
Age
18 Years - 110 Years
Healthy Volunteers
Not accepted

Study Details

The purpose of the registry and biorepository is to provide a mechanism to store clinical data, linked biospecimens and molecular data to support the conduct of future research on Systemic Lupus Erythematosus (SLE), including Lupus Nephritis (LN).

Key Dates

Start date
Jun 28, 2023
Status verified
Apr 2026
Primary completion
Dec 31, 2035
Completion
Dec 31, 2035

Study Design

Enrollment
3,500 participants (estimated)

Arms

  • Arm: New Onset
    Individuals with a new diagnosis of SLE
  • Arm: LN Active
    Individuals with a recent diagnosis of Lupus Nephritis
  • Arm: Extra-renal Flare
    Individuals who have experienced a recent flare
  • Arm: Prevalent
    Individuals with lupus who do not meet the criteria for one of the other cohorts

Primary Outcome Measure

Identify genetic drivers and antigenic targets, to elucidate mechanistic heterogeneity and correlate biomarkers to therapeutic responses. [ Time Frame: up to 25 years ]

Central Contacts

Locations (19)

FacilityCityStateZIPSite coordinators
University of Alabama at BirminghamBirminghamAlabama35205
Christina Ndolo
[email protected]
Jose Rubio Mosquera, MD (PRINCIPAL_INVESTIGATOR)
University of ArizonaTucsonArizona85714
Lydia Benitez
[email protected]
Kent Kwoh, MD (PRINCIPAL_INVESTIGATOR)
Wallace Rheumatic Studies CenterBeverly HillsCalifornia90210
Karla Alvarez
[email protected]
Daniel Wallace, MD, FACP, MACR (PRINCIPAL_INVESTIGATOR)
UCLALos AngelesCalifornia90024
Brian Skaggs
[email protected]
3108254321
Maureen McMahon, MD (PRINCIPAL_INVESTIGATOR)
Georgetown UniversityWashington D.C.District of Columbia20057
Akua Ofori
[email protected]
2026870100
Megan Lockwood, MD (PRINCIPAL_INVESTIGATOR)
Virginia Steen, MD (SUB_INVESTIGATOR)
Abraham Aron, MD (SUB_INVESTIGATOR)
University of MiamiMiamiFlorida33146
Luis Enrique Arias Mejia
[email protected]
Niurka Colina
[email protected]
Maria Carpintero, MD (PRINCIPAL_INVESTIGATOR)
Emory UniversityAtlantaGeorgia30322
Kennedy Vela
[email protected]
John Varghese
[email protected]
Arezou Khosroshahi, MD (PRINCIPAL_INVESTIGATOR)
University of ChicagoChicagoIllinois60637
Rennan Ruivivar
[email protected]
Yusra Irshad
[email protected]
Kimberly Trotter, MD (PRINCIPAL_INVESTIGATOR)
Brigham and Women's HospitalBostonMassachusetts02115
Norioscar Cabello
[email protected]
6177325500
Elena Massarotti, MD (PRINCIPAL_INVESTIGATOR)
Karen Costenbader, MD (SUB_INVESTIGATOR)
University of Massachusetts Memorial HealthWorcesterMassachusetts01605
Chelsea Boateng
[email protected]
Roberto Caricchio, MD (PRINCIPAL_INVESTIGATOR)
Washington UniversitySt LouisMissouri63130
Maribel Chebuske
[email protected]
Alfred Kim, MD, PhD (PRINCIPAL_INVESTIGATOR)
Jessica Williams, MD, MPH (SUB_INVESTIGATOR)
The Feinstein Institutes for Medical ResearchManhassetNew York11030
Meggan Mackay, MD, MS (PRINCIPAL_INVESTIGATOR)
Cynthia Aranow, MD (SUB_INVESTIGATOR)
Columbia University Medical CenterNew YorkNew York10032
Maria Ycaza
[email protected]
Laura Geraldino-Pardilla, MD (PRINCIPAL_INVESTIGATOR)
Northwell HealthNew YorkNew York11021
Abdul Rehman
[email protected]
Richard Furie, MD (PRINCIPAL_INVESTIGATOR)
SUNY UpstateSyracuseNew York13210
Kristina Keburia
[email protected]
(315) 464-6481
Carly Becker
[email protected]
Andras Perl, MD, PhD (PRINCIPAL_INVESTIGATOR)
UNC Chapel HillChapel HillNorth Carolina27599
Anthony Trujillo
[email protected]
Shruti Saxena Beem
[email protected]
Saira Sheikh, MD (PRINCIPAL_INVESTIGATOR)
The MetroHealth SystemClevelandOhio44109
Antoniy Fulmes
[email protected]
Joe Finn
[email protected]
Nora Singer, MD (PRINCIPAL_INVESTIGATOR)
Vanderbilt University Medical CenterNashvilleTennessee37232
Pamela Schlairet
[email protected]
Narender Annapureddy, MD (PRINCIPAL_INVESTIGATOR)
UT Southwestern Medical CenterDallasTexas75390
Nazeem Mohammed
[email protected]
Serey Ol
[email protected]
David Karp, MD (PRINCIPAL_INVESTIGATOR)
Maria Bacalao, MD (SUB_INVESTIGATOR)

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