Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,674 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,674 clinical trials

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Clinical Data Registry of Amblyopia Patients on Luminopia Treatment

for Amblyopia

13 locations incl. San Ramon

Sponsor: Luminopia

Sex: All·Age: All ages

Code: NCT06429280·Recruiting

Apply to this trial

Functional Recovery After Total Knee Arthroplasty

for Arthritis Knee

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 40 - 90

Code: NCT06821269·Recruiting

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HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP

for Erythropoietic Protoporphyria

11 locations incl. Birmingham

Sponsor: Disc Medicine, Inc

Sex: All·Age: 12+

Code: NCT05883748·Phase 2, Phase 3·Enrolling By Invitation

A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis

for Primary Biliary Cholangitis (PBC)

Drug: Elafibranor

40 locations incl. Tucson

Sponsor: Ipsen

Sex: All·Age: 18+

Code: NCT06016842·Phase 3·Recruiting

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Study of AVZO-021 in Patients With Advanced Solid Tumors

for Advanced Solid Tumor

11 locations incl. New Haven

Sponsor: Avenzo Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05867251·Phase 1, Phase 2·Recruiting

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STXBP1 and SYNGAP1 Related Disorders Natural History Study

for Genetic Disease

5 locations incl. Palo Alto

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT06555965·Recruiting

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A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)

for PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)

3 locations incl. La Jolla

Sponsor: Rocket Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05885412·Phase 1·Recruiting

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Tazemetostat and Palbociclib With CPX-351for R/R AML

for Recurrent Acute Myeloid Leukemia

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT05627232·Phase 1·Recruiting

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Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in Pregnancy

for Opioid Use Disorder

1 location in Pittsburgh

Sponsor: Ilana Hull

Sex: Female·Age: 18+

Code: NCT05942313·Recruiting

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A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)

for Psychosis Associated With Alzheimer's Disease

Drug: KarXT

70 locations incl. Chandler

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 55 - 90

Code: NCT06126224·Phase 3·Recruiting

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US National OCS Heart Perfusion (OHP) Registry

for Heart Transplant

37 locations incl. Phoenix

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT05915299·Recruiting

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Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

for Heart Failure

47 locations incl. Phoenix

Sponsor: Procyrion

Sex: All·Age: 21+

Code: NCT05677100·Recruiting

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ATSN-201 Gene Therapy in RS1-Associated X-linked Retinoschisis

for X-linked Retinoschisis

4 locations incl. Los Angeles

Sponsor: Atsena Therapeutics Inc.

Sex: All·Age: 6+

Code: NCT05878860·Phase 3·Recruiting

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Responding With Evidence and Access for Childhood Headaches

for Headache

15 locations incl. Birmingham

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 10 - 17

Code: NCT05889624·Recruiting

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A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis

for Atopic Dermatitis

Drug: PF-07275315

52 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT05995964·Phase 2·Recruiting

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Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma

for Cholangiocarcinoma

Drug: Trametinib

10 locations incl. Los Angeles

Sponsor: Genfit

Sex: All·Age: 18+

Code: NCT05874414·Phase 1, Phase 2·Recruiting

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Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis

for Sepsis

4 locations incl. Atlanta

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT05975671·Recruiting

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Exparel vs Block for ACL Reconstruction

for ACL

1 location in Philadelphia

Sponsor: Rothman Institute Orthopaedics

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06006624·Phase 4·Enrolling By Invitation

A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma

for Cardiovascular Disorder

31 locations incl. Mobile

Sponsor: Children's Oncology Group

Sex: All·Age: 7+

Code: NCT05705531·Recruiting

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Testing ANSOS for Efficacy in Multi-Tribal Urban Communities

for Smokeless Tobacco Cessation

1 location in Bethlehem

Sponsor: Lehigh University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06566703·Recruiting

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A Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With PCED

for Persistent Corneal Epithelial Defect

21 locations incl. Dothan

Sponsor: Glaukos Corporation

Sex: All·Age: 2+

Code: NCT05966493·Phase 2·Recruiting

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IBS Skin Patch Test Food Allergy Study

for Irritable Bowel Syndrome

2 locations incl. North Wales

Sponsor: IBS-80, LLC

Sex: All·Age: 18+

Code: NCT06288672·Recruiting

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Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

for Prostate Cancer

24 locations incl. Scottsdale

Sponsor: Novartis Pharmaceuticals

Sex: Male·Age: 18 - 100

Code: NCT05803941·Phase 4·Recruiting

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A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet in Women With Uterine Fibroids or Endometriosis

for Uterine Fibroids

Drug: Relugolix

120 locations incl. Mobile

Sponsor: Sumitomo Pharma Switzerland GmbH

Sex: Female·Age: 18 - 50

Code: NCT05862272·Phase 3·Recruiting

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Regeneration of Acutely Injured Nerves With Temporary Electrical Stimulation

for Nerve Injury

6 locations incl. Gainesville

Sponsor: Epineuron Technologies Inc.

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05721261·Recruiting

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Evaluation of Long-Term Safety and Efficacy of Vanzacaftor/Tezacaftor/Deutivacaftor in Cystic Fibrosis Participants 1 Year of Age and Older

for Cystic Fibrosis

18 locations incl. Orange

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 1+

Code: NCT05844449·Phase 3·Enrolling By Invitation

Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

for Anatomic Stage III Breast Cancer AJCC v8

7 locations incl. Los Angeles

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT05372640·Phase 1·Recruiting

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Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM

for Hypertrophic Cardiomyopathy

10 locations incl. La Jolla

Sponsor: Tenaya Therapeutics

Sex: All·Age: 18 - 75

Code: NCT05836259·Phase 1, Phase 2·Recruiting

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A Study of ASKG915 in Patients With Selected Advanced Solid Tumors.

for Advanced Solid Tumors

2 locations incl. New York

Sponsor: AskGene Pharma, Inc.

Sex: All·Age: 18+

Code: NCT05867420·Phase 1, Phase 2·Recruiting

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Disentangling the Role of Depression in Hypersomnia

for Hypersomnia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 21 - 55

Code: NCT05850676·Recruiting

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Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

for Colonic Neoplasms

Drug: Dostarlimab

49 locations incl. Tucson

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT05855200·Phase 3·Recruiting

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Adaptive Radiation for Abdominopelvic Metastases

for Neoplasm - Soft Tissue Pelvis Malignant Secondary

1 location in Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT05880667·Phase 1·Recruiting

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Observational Study for Patients at Risk for Chronic Graft-Versus-Host Disease

for cGVHD

32 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT05919511·Recruiting

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Diet and Motility in IBS

for Irritable Bowel Syndrome (IBS)

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 8 - 18·Accepts healthy volunteers

Code: NCT07283341·Recruiting

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A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes

for Type 1 Diabetes Mellitus With Hypoglycemia

38 locations incl. Birmingham

Sponsor: Zucara Therapeutics Inc.

Sex: All·Age: 18 - 75

Code: NCT05762107·Phase 2·Recruiting

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Trauma Resuscitation With Low-Titer Group O Whole Blood or Products

for Wounds and Injuries

13 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 15+

Code: NCT05638581·Phase 3·Recruiting

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Lurbinectedin in FET-Fused Tumors

for Ewing Sarcoma

Drug: Lurbinectedin

6 locations incl. Los Angeles

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 10+

Code: NCT05918640·Phase 1, Phase 2·Recruiting

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A Registry for People With T-cell Lymphoma

for T-cell Lymphoma

26 locations incl. Duarte

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: All ages

Code: NCT05978141·Recruiting

Apply to this trial

Food Genetics Behavior Study

for Obesity, Childhood

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 5 - 7·Accepts healthy volunteers

Code: NCT05783765·Recruiting

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Tocilizumab and Atezolizumab in Adults With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Refractory to 1st Line Immune Checkpoint Inhibitor-Based Therapy

for Lung Cancer, Nonsmall Cell

Drug: Atezolizumab

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04691817·Phase 1, Phase 2·Recruiting

Apply to this trial