A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma

Conditions

• Cardiovascular Disorder
• Classic Hodgkin Lymphoma
• Clonal Hematopoiesis

Eligibility Criteria

Sex

ALL

Age

7 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Archive Sample Retrieval — PROCEDURE
  Undergo collection of archived blood sample
• Biospecimen Collection — PROCEDURE
  Undergo blood sample collection
• Electronic Health Record Review — OTHER
  Undergo medical record abstraction
• Magnetic Resonance Imaging — PROCEDURE
  Undergo MRI
• Survey Administration — OTHER
  Complete surveys

Study Details

This study assesses how blood cell growth patterns (clonal hematopoiesis) relate to heart health or cardiovascular disease (CVD) after treatment in patients with Hodgkin lymphoma. In some patients, cancer treatment at a young age may lead to later complications, including problems with heart health. Checking for blood cell growth patterns called therapy-related clonal hematopoiesis (t-CH) can help predict who might be at risk for heart health problems after Hodgkin lymphoma treatment. If doctors know who may be at greater risk for developing later heart complications, then they can more closely monitor those patients to prevent or detect heart complications early.

Key Dates

Start date

Aug 18, 2023

Status verified

Feb 2026

Primary completion

Oct 1, 2028

Completion

Oct 1, 2028

Study Design

Enrollment

190 participants (estimated)

Arms

• Arm: Observational (blood samples, surveys, MRI, record review)
  Patients undergo collection of blood samples, complete surveys, and undergo cardiac MRI on study. Patients also have their medical records reviewed and may have archived blood samples collected if available.

Primary Outcome Measure

Therapy-related clonal hematopoiesis (t-CH) with mutations associated with cardiovascular disease [ Time Frame: Up to 1 year ]

Locations (31)

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