Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks

for Overweight or Obesity

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18 - 39·Accepts healthy volunteers

Code: NCT05674799·Recruiting

Apply to this trial

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

for Advanced Malignant Solid Neoplasm

475 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: All ages

Code: NCT05564377·Phase 2·Recruiting

Apply to this trial

The SKyRoCKeT Study

for Healthy

1 location in Charlotte

Sponsor: University of North Carolina, Charlotte

Sex: All·Age: 6 - 20·Accepts healthy volunteers

Code: NCT05770817·Recruiting

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A Study of TAK-861 for the Treatment of Selected Central Hypersomnia Conditions

for Narcolepsy Type 1

19 locations incl. Birmingham

Sponsor: Takeda

Sex: All·Age: 16 - 70

Code: NCT05816382·Phase 2, Phase 3·Recruiting

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Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes

for Type 1 Diabetes

2 locations incl. Durham

Sponsor: Duke University

Sex: All·Age: 16 - 50

Code: NCT05540704·Recruiting

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Cardiovascular Effects of Very Low Nicotine Content Cigarettes

for Tobacco Use

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT05707871·EARLY_Phase 1·Recruiting

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PRospective Evaluation of Peripartum Anticoagulation ManaGement for ThrOmboembolism

for Pregnancy Related

1 location in Durham

Sponsor: University of Calgary

Sex: Female·Age: 18 - 60

Code: NCT05756244·Recruiting

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Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

for Prediabetic State

40 locations incl. Phoenix

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT02915198·Phase 4·Recruiting

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Optimizing Tracheal Intubation Outcomes and Neonatal Safety

for Infant

7 locations incl. Little Rock

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: Up to 1

Code: NCT05838690·Recruiting

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Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)

for Sickle Cell Trait

10 locations incl. Birmingham

Sponsor: National Alliance for Sickle Cell Centers

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06071377·Recruiting

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A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

for Breast Cancer, Early Breast Cancer

Drug: Camizestrant

127 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT05774951·Phase 3·Recruiting

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Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms

for T-Cell Neoplasm

Drug: Pacritinib

6 locations incl. Duarte

Sponsor: University of Michigan Rogel Cancer Center

Sex: All·Age: 18+

Code: NCT04858256·Phase 2·Recruiting

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Bisphosphonate Use to Mitigate Bone Loss Secondary to Bariatric Surgery

for Bone Loss

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 30+

Code: NCT04922333·Phase 3·Recruiting

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Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

for Breast Cancer

15 locations incl. Orlando

Sponsor: Incyclix Bio

Sex: All·Age: 18+

Code: NCT05735080·Phase 1, Phase 2·Recruiting

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Total Intravenous Anesthesia (TIVA)/Sevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients

for Extubation

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: Up to 9

Code: NCT05837936·Recruiting

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An Observational Retrospective Cohort Study Being Conducted in Women With Atopic Dermatitis Exposed to Ruxolitinib Cream Versus Topical Corticosteroids During Pregnancy: A US Claims Database Analysis

for Pregnancy Related

Drug: Ruxolitinib

1 location in Morrisville

Sponsor: Incyte Corporation

Sex: Female·Age: 14+

Code: NCT06627335·Recruiting

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Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

for Breast Cancer

10 locations incl. Birmingham

Sponsor: American College of Radiology

Sex: Female·Age: 45 - 74·Accepts healthy volunteers

Code: NCT05625659·Recruiting

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A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251

for Geographic Atrophy

15 locations incl. Beverly Hills

Sponsor: Genentech, Inc.

Sex: All·Age: 50+

Code: NCT05626114·Phase 2·Recruiting

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Tafasitamab and Rituximab for Front-Line Treatment of Post-Transplant Lymphoproliferative Disorder

for Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder

Drug: Tafasitamab

4 locations incl. New Brunswick

Sponsor: Timothy Voorhees

Sex: All·Age: 18+

Code: NCT05786040·Phase 2·Recruiting

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Geriatric Evaluation and Management With Survivorship Health Education for Older Survivors of Cancer, GEM-S Trial

for Lymphoma

45 locations incl. Tuscaloosa

Sponsor: University of Rochester

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05006482·Phase 3·Recruiting

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A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Etentamig

26 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT05650632·Phase 1·Recruiting

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Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

for Recurrent Glioblastoma, IDH-Wildtype

Drug: Selinexor

36 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05432804·Phase 1, Phase 2·Recruiting

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Disease Outcomes and Toxicities in Patients With Gastrointestinal and Sarcomatous Malignancies

for Sarcoma

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05743426·Recruiting

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Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)

for Von Willebrand Diseases

10 locations incl. Los Angeles

Sponsor: Vega Therapeutics, Inc

Sex: All·Age: 12 - 60·Accepts healthy volunteers

Code: NCT05776069·Phase 1, Phase 2·Recruiting

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Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or ICI, for the Treatment of Patients With Advanced Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)

for Gastric or Gastroesophageal Junction Adenocarcinoma

11 locations incl. Duarte

Sponsor: Phanes Therapeutics

Sex: All·Age: 18+

Code: NCT05482893·Phase 1, Phase 2·Recruiting

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Comparison of CE-DBT and MRI in Patients With Known Breast Lesions

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT05754749·EARLY_Phase 1·Recruiting

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Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer

for Breast Carcinoma

5 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05557877·Phase 2·Recruiting

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Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment

for Cardiac Resynchronization Therapy

4 locations incl. Chicago

Sponsor: XSpline S.p.A.

Sex: All·Age: 18+

Code: NCT05327062·Recruiting

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A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

for High Grade Osteosarcoma

Drug: Cabozantinib

177 locations incl. Charlottesville

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 40

Code: NCT05691478·Phase 2, Phase 3·Recruiting

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The GORE® VIABAHN® FORTEGRA Venous Stent Iliofemoral Study

for Venous Thromboses

27 locations incl. Stanford

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT05489588·Recruiting

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Improving Exercise Capacity With a Tailored Physical Activity Intervention

for Non Hodgkin Lymphoma

2 locations incl. Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 85

Code: NCT05595577·Recruiting

Apply to this trial

HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

for Heart Failure

6 locations incl. Sacramento

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT05873634·Recruiting

Apply to this trial

Transmission and Acquisition of Nontuberculous Mycobacteria Outbreak Investigation (TrANsMIt)

for Nontuberculous Mycobacterial Pulmonary Infection

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 1 Month - 99

Code: NCT06155747·Recruiting

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A Study of Baricitinib (LY3009104) in Children From 6 Years to Less Than 18 Years of Age With Alopecia Areata

for Areata Alopecia

Drug: Baricitinib

44 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 6 - 17

Code: NCT05723198·Phase 3·Recruiting

Apply to this trial

BOTOX® vs. XEOMIN® for Chronic Migraine

for Chronic Migraine

Drug: Xeomin

1 location in Jacksonville

Sponsor: Naval Medical Center Camp Lejeune

Sex: All·Age: 18 - 89

Code: NCT05598723·Phase 3·Recruiting

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REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19

for COVID-19

5 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT05218083·Recruiting

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A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

for Multiple Myeloma

13 locations incl. San Francisco

Sponsor: K36 Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05651932·Phase 1·Recruiting

Apply to this trial

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

for Cancer Harboring BRAF Alterations

30 locations incl. Beverly Hills

Sponsor: Fore Biotherapeutics

Sex: All·Age: 10+

Code: NCT05503797·Phase 2·Recruiting

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Treatment of Calcific Total Occlusions in Peripheral Artery Disease

for Chronic Total Occlusion of Artery of the Extremities

3 locations incl. Fort Lauderdale

Sponsor: SoundBite Medical Solutions, Inc.

Sex: All·Age: 19+

Code: NCT05551780·Recruiting

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VIrtual STudy in Achondroplasia for the US (VISTA)

for Achondroplasia

7 locations incl. Oakland

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 0 Months - 18

Code: NCT06168201·Recruiting

Apply to this trial