Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

2,930 clinical trials

↓ Download CSV

Duke Cardiometabolic Prevention Clinic's Impact on High-risk Cardiovascular Patients With Uncontrolled Risk Factors

for ASCVD

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07117695·Not Yet Recruiting

An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED

for Persistent Corneal Epithelial Defect

18 locations incl. Huntington Beach

Sponsor: Dompé Farmaceutici S.p.A

Sex: All·Age: 18+

Code: NCT07519902·Phase 3·Recruiting

Apply to this trial

Shared Decision Making to Address Racial Disparities in Oral Anticoagulation in NVAF

for Atrial Fibrillation

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04956978·Not Yet Recruiting

Planning Grant for TOPS for Breast Cancer Survivors

for Breast Cancer

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 21 - 90

Code: NCT06658912·Not Yet Recruiting

Using Community Health Workers to Support Rural Care Partners of Seriously Ill Older Veterans

for Dementia

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06963970·Not Yet Recruiting

Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal Pain

for Spine

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06987786·Not Yet Recruiting

A RCT of Spectacles With Aspherical Lenslets or 0.05% Atropine for Myopia Control

for Myopia

12 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 5 - 11

Code: NCT07095894·Phase 3·Recruiting

Apply to this trial

Supporting Families in the ICU

for Anxiety

2 locations incl. San Francisco

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT07228299·Not Yet Recruiting

Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia

for Knee Stiffness After Total Knee Arthroplasty

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 75

Code: NCT07348614·Phase 4·Recruiting

Apply to this trial

Overnight TI in TLE

for Temporal Lobe Epilepsy (TLE)

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 70

Code: NCT07434986·Not Yet Recruiting

A Phase 2 Clinical Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) in Patients With Severe Asthma

for Severe Asthma

Drug: Frevecitinib

15 locations incl. Lancaster

Sponsor: Kinaset Therapeutics Inc

Sex: All·Age: 18 - 75

Code: NCT07532265·Phase 2·Not Yet Recruiting

Teen Vulnerability to Irritability: Brain and Estrogen Changes

for Depression - Major Depressive Disorder

2 locations incl. Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 12 - 16·Accepts healthy volunteers

Code: NCT07544966·Phase 4·Not Yet Recruiting

Auditory Stimulation for Insomnia and Depression

for Depression - Major Depressive Disorder

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 20 - 50

Code: NCT07553364·Not Yet Recruiting

Anakinra Rescue Treatment for Moderate Asthma Attacks (ARTMA)

for Asthma (Diagnosis)

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07600190·Phase 1·Not Yet Recruiting

Effects of Infusion Timing on Treatment Response in Solid Tumors

for Lung Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07630168·Phase 2·Not Yet Recruiting

A Study Testing a Digital, Gamified Early Intervention for Eating Disorders ("FlexED")

for Eating Disorders

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 15 - 25

Code: NCT07632248·Not Yet Recruiting

Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress: the Lift RCT

for Critical Illness

3 locations incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07634419·Not Yet Recruiting

A Collaborative Community Effort Using Belantamab Mafodotin in Relapsed/Refractory Myeloma

for Relapsed/Refractory Multiple Myeloma

Drug: Belantamab mafodotin

5 locations incl. Clayton

Sponsor: Cristiana Costa Chase, DO

Sex: All·Age: 18+

Code: NCT05874193·Phase 2·Not Yet Recruiting

Evaluation of Impact of AI Assistance on Workload Associated w Preparation of Rare Tumor Case Repts

for Cognitive Burden

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06026098·Not Yet Recruiting

Virtual Testis Cancer Lay Support and Survivorship Aim 2

for Testicular Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Male·Age: 18 - 95

Code: NCT06702592·Not Yet Recruiting

ESP Blocks for Posterior Spinal Fusion

for Postoperative Pain

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 75

Code: NCT07228039·Phase 4·Not Yet Recruiting

A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

for Breast Neoplasms

25 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: Female·Age: 18+

Code: NCT07287098·Phase 2·Not Yet Recruiting

Overcoming Barriers to Uptake of Cascade Screening

for Lynch Syndrome

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07304063·Not Yet Recruiting

The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury

for Caregiver Distress

3 locations incl. Baltimore

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07331324·Not Yet Recruiting

Signatera Assessment in Early-Stage Endometrial Cancer

for Endometrial Cancer

9 locations incl. Birmingham

Sponsor: Natera, Inc.

Sex: Female·Age: 18+

Code: NCT07339384·Not Yet Recruiting

Health Enhanced Artery Risk Tracking With Widespread Implementation and Screening Effort in ASCVD (HEARTWISE-ASCVD)

for Atherosclerotic Cardiovascular Disease (ASCVD)

6 locations incl. Los Angeles

Sponsor: Stanford University

Sex: All·Age: 18 - 74

Code: NCT07355894·Not Yet Recruiting

SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers

for Healthy Volunteers

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT07429292·Phase 4·Not Yet Recruiting

Olutasidenib in Relapsed IDH1 Mutated AML Patients Who Have Previously Received Venetoclax

for IDH1 Mutation

Drug: Venetoclax

1 location in Winston-Salem

Sponsor: Timothy Pardee

Sex: All·Age: 18+

Code: NCT07471841·Phase 2·Not Yet Recruiting

ACT to Reduce Morbidity and Mortality in Hematopoietic Stem Cell Transplant Patients

for Stem Cell Transplant Patients

2 locations incl. Kansas City

Sponsor: Anthony Sung, MD

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07516314·Not Yet Recruiting

Safer Drinking Spaces Study

for Sexual Violence

3 locations incl. Gainesville

Sponsor: RTI International

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07527988·Not Yet Recruiting

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

for Treatment-resistant Depression (TRD)

38 locations incl. Birmingham

Sponsor: Alto Neuroscience

Sex: All·Age: 18 - 75

Code: NCT07553637·Phase 2·Recruiting

Apply to this trial

Supporting Just-In-Time Consent for Prenatal Screening: The INFORM Study

for Delivery of Health Care

3 locations incl. San Francisco

Sponsor: Case Western Reserve University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07557303·Not Yet Recruiting

ANDREAS Registry (Assessment of Novel Drug-coated Balloon Revascularization: Effectiveness, Angiographic Outcomes, and Safety)

for Coronary Artery Disease

16 locations incl. Phoenix

Sponsor: Emory University

Sex: All·Age: 18+

Code: NCT07559903·Not Yet Recruiting

CVFs in SIH: EID vs. PCD CTM

for Spontaneous Intracranial Hypotension

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07582744·Not Yet Recruiting

IAP-086-1: A Phase 1 Single Ascending Dose First-Time in Human Study

for HIV-1-infection

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT07596888·Phase 1·Not Yet Recruiting

A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).

for Alzheimer Disease

Drug: Donanemab

52 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 55+

Code: NCT07602582·Phase 3·Not Yet Recruiting

Blast Overpressure Longitudinal Study

for Low-level Blast Exposure

3 locations incl. Bethesda

Sponsor: Uniformed Services University of the Health Sciences

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT07606651·Not Yet Recruiting

Clinical Outcomes of 3D Printed and Milled Complete Dentures

for Edentulous Mouth

1 location in Chapel Hill

Sponsor: Dentsply Sirona Implants and Consumables

Sex: All·Age: 18+

Code: NCT07586774·Not Yet Recruiting

Treatment of Antibody-Mediated Rejection (ABMR) With CarBel

for Kidney Transplant Rejection

10 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT06918990·Phase 1·Recruiting

Apply to this trial

Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events

for Obesity

11 locations incl. Walnut Creek

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07607587·Phase 1·Not Yet Recruiting