Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

for Relapsed/Refractory Primary Central Nervous System Lymphoma

Drug: Rituximab

14 locations incl. Phoenix

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT07104032·Phase 3·Recruiting

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Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up

for Epilepsy

12 locations incl. Phoenix

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110454·Recruiting

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Mindfulness in Nonflaccid Facial Paralysis

for Facial Paralysis

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07127016·Not Yet Recruiting

Narrative Medicine Effects on Burnout and Stress

for Healthcare Professionals

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT07136597·Not Yet Recruiting

UNC Cashew Sublingual Immunotherapy

for Cashew Nut Allergy

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 1 - 11

Code: NCT07170540·Phase 2·Not Yet Recruiting

Comprehensive Care for AYA: Needs Assessment Survey

for Cancer

2 locations incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 15+

Code: NCT07196241·Recruiting

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Study of Monochromatic X-ray Mammography System

for Breast Imaging

1 location in Durham

Sponsor: Imagine Scientific, Inc.

Sex: Female·Age: 40+

Code: NCT07219797·Not Yet Recruiting

Behavioral Pain Intervention for Older Cancer Patients

for Breast Cancer

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 55+

Code: NCT07300995·Recruiting

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Pilot Study of Continuous Glucose Monitoring for Postpartum Glucose Screening

for Gestational Diabetes

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18+

Code: NCT07332416·Enrolling By Invitation

Efficacy of Intravenous Oxytocin to Speed Recovery After THA

for Total Hip Arthroplasty

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 75

Code: NCT07430228·Phase 2·Enrolling By Invitation

Integrating New Skills Into Diabetes Education With CGM

for Insulin Dependent Diabetes

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 65+

Code: NCT07463209·Not Yet Recruiting

H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) and Pembrolizumab (Keytruda) in Surgically Resectable, HPV Negative Oral Cavity Squamous Cell Carcinoma (OCSCC)

for Oral Cavity Squamous Cell Carcinoma

3 locations incl. Atlanta

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07484139·Phase 2·Not Yet Recruiting

Study to Evaluate HM15275 in Subjects With Type 2 Diabetes Mellitus

for Type 2 Diabetes Mellitus

10 locations incl. Glendale

Sponsor: Hanmi Pharmaceutical Company Limited

Sex: All·Age: 18 - 75

Code: NCT07527650·Phase 2·Recruiting

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A Study of LY3971297 in Participants With Heart Failure

for Heart Failure

Drug: LY3971297

2 locations incl. St Louis

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 65

Code: NCT07547540·Phase 1·Not Yet Recruiting

Phenobarbital for Agitated Delirium

for Agitated Delirium

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT07548489·Phase 3·Not Yet Recruiting

A Study of Weekly Oral Dose of Ecnoglutide (VRB-101) for Weight Maintenance in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

for Obesity

17 locations incl. Cullman

Sponsor: Verdiva Bio Dev Limited

Sex: All·Age: 18 - 80

Code: NCT07553299·Phase 2·Not Yet Recruiting

The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma

for Osteosarcoma in Children

8 locations incl. Chapel Hill

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 7 - 22

Code: NCT07560826·Phase 2·Not Yet Recruiting

Early Dental Risk Screening for Pediatric Sleep-Disordered Breathing

for Early Risk Screening for Sleep Disordered Breathing in a Dental Setting

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 8 - 13·Accepts healthy volunteers

Code: NCT07581938·Recruiting

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A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

for Overweight

Drug: Eloralintide

40 locations incl. The Villages

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07589608·Phase 2·Not Yet Recruiting

Intraoperative Peripheral Nerve Stimulation

for Compression Neuropathy

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07592065·Not Yet Recruiting

Links Between Epileptic Activity, Sleep Disruption and Mental Content During Sleep

for Patients With Drug-resistant Focal Epilepsy

1 location in Durham

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18 - 55

Code: NCT07605858·Recruiting

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A Study to Evaluate the Efficacy and Safety of Concomitant Use of Eplontersen and ALXN2220 Compared With Eplontersen and Placebo for Adults Participants With ATTR-CM

for Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

24 locations incl. La Jolla

Sponsor: AstraZeneca

Sex: All·Age: 18 - 85

Code: NCT07608354·Phase 2·Not Yet Recruiting

Efficacy, Safety, and Tolerability of Zeleciment Rostudirsen (DYNE-251) Administered Intravenously Every 4 Weeks in Ambulatory Participants With Duchenne Muscular Dystrophy (FORZETTO)

for Duchenne Muscular Dystrophy (DMD)

1 location in Hillsborough

Sponsor: Dyne Therapeutics

Sex: Male·Age: 4 - 18

Code: NCT07608432·Phase 3·Recruiting

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Testing STAR and TextSTAR: A Randomized Controlled Trial

for Sexual Violence

3 locations incl. Louisville

Sponsor: University of Wisconsin, Madison

Sex: Female·Age: 18+

Code: NCT07630428·Enrolling By Invitation

RIsE Stroke Mobility Study

for Acute Ischemic Stroke

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07638462·Not Yet Recruiting

Olomorasib + Pembrolizumab KRAS G12C Mutant, PD-L1 TPS 1-49% Locally Advanced or Metastatic NSCLC

for Lung Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07639242·Phase 2·Not Yet Recruiting

Trial of CGM Technology in Persons Living With Prediabetes

for Prediabetes

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07639593·Not Yet Recruiting

A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia

for Hypercholesterolemia

Drug: Alirocumab

6 locations incl. Sunrise

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18 - 80

Code: NCT07477704·Phase 2·Recruiting

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Small Trial of Alendronate Impact on the Reservoir of HIV

for HIV

5 locations incl. San Francisco

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 65

Code: NCT07216794·Phase 2·Not Yet Recruiting

Post-refractive IOL Outcomes With Clareon TruPlus

for Cataract

1 location in Greensboro

Sponsor: Laser Defined Vision

Sex: All·Age: 18+

Code: NCT07610226·Not Yet Recruiting

A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation

for Atrial Fibrillation

6 locations incl. San Francisco

Sponsor: Bayer

Sex: All·Age: 18 - 85

Code: NCT07625215·Phase 2·Not Yet Recruiting

A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity

for Obesity

1 location in Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 5 - 12

Code: NCT07437976·Not Yet Recruiting

Efficacy of Tezepelumab in Peanut Oral Immunotherapy

for Peanut Allergy

10 locations incl. Little Rock

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12 - 55

Code: NCT07015996·Phase 2·Not Yet Recruiting

Virtual Activities of Living for Occupational Rehabilitation

for Stroke

1 location in Durham

Sponsor: Barron Associates, Inc.

Sex: All·Age: 18+

Code: NCT07450586·Not Yet Recruiting

Beginning to Assess an Appropriate CONtrol for Oral Food Challenges in Alpha-Gal Syndrome (CoFAR-13) - BeACON4AG

for Alpha-Gal Syndrome

4 locations incl. Little Rock

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12 - 50

Code: NCT07611435·Phase 2·Not Yet Recruiting

A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection

for HIV-1-infection

10 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT06987318·Phase 1·Not Yet Recruiting

A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity

for Obesity

Drug: NNC0662-0419

24 locations incl. Montgomery

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07639021·Phase 2·Not Yet Recruiting

Strength Training Exercise in Pediatric Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (STEP-ALL)

for Leukemia

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 6+·Accepts healthy volunteers

Code: NCT07634653·Not Yet Recruiting

Safety of MOON101 for the Treatment of Peanut Allergy

for Peanut Allergy

5 locations incl. Little Rock

Sponsor: Moonlight Therapeutics, Inc.

Sex: All·Age: 4 - 55

Code: NCT07580898·Phase 1·Recruiting

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Enhancing Slow Wave Sleep in Depression

for Depression - Major Depressive Disorder

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 40 - 80

Code: NCT07143838·Recruiting

Apply to this trial